John Dubek

US Patent:

20030215525, Nov 20, 2003

Filed:

Nov 26, 2002

Appl. No.:

10/304837

Inventors:

Douglas Beyerle - Lansdale PA, US
John Dubek - Philadelphia PA, US
Gerard McNally - Berwyn PA, US
Donald Hasenmayer - North Wales PA, US
John Case - Perkasie PA, US
Abbie Gentry - Horsham PA, US
Indu Shah - North Wales PA, US

International Classification:

A61K033/12
A61K033/08
A61K033/10
A61K031/717

US Classification:

424/683000, 424/690000, 424/687000, 424/686000, 514/057000

Abstract:

The invention relates to heat stable liquid antacid and/or antigas preparations capable of being pasteurized in the temperature range of 60-100 C. comprising one or more acid neutralizing and/or antigas compounds in an aqueous liquid suspension consisting essentially of hydroxyethylcellulose as a suspending agent.

US Patent:

58741127, Feb 23, 1999

Filed:

Mar 31, 1997

Appl. No.:

8/828622

Inventors:

Gerard P. McNally - Strafford PA
John J. Dubek - Philadelphia PA

Assignee:

McNeil PPC-Inc. - New Brunswick NJ

International Classification:

A61K 3308

US Classification:

424690

Abstract:

An essentially translucent antacid composition is formed by an aqueous colloidal aluminum hydroxide gel wherein the average particle size of the aluminum hydroxide is less than about 0. 5 microns, preferably less than about 0. 1 microns, and more preferably less than about 0. 01 microns. The suspension is further preferably mixed with a polyol, such as sorbitol or maltitol, to enhance the translucency. The weight ratio of polyol to aluminum hydroxide gel (USP) ranges from about 0. 5:1. 0 to about 4. 0:1.

US Patent:

59194812, Jul 6, 1999

Filed:

Jun 28, 1996

Appl. No.:

8/671991

Inventors:

Sharon L. Cody - Erie PA
Brid T. Devlin - Conshohocken PA
John Dubek - Philadelphia PA
Michael R. Hoy - Sellersville PA

Assignee:

NcNeil-PPC, Inc. - Skillman NJ

International Classification:

A61K 948

US Classification:

424452

Abstract:

The present invention relates to a substantially translucent, semi-solid fill material for a soft gelatin capsule containing a therapeutically effective amount of a pharmaceutical dissolved or suspended in the semi-solid. The semi-solid is sufficiently viscous so that it cannot be readily expelled at room temperature from the capsule with a syringe.

US Patent:

59141352, Jun 22, 1999

Filed:

Apr 16, 1997

Appl. No.:

8/838239

Inventors:

John J. Dubek - Philadelphia PA
Gerard P. McNally - Strafford PA
Bruce P. Smith - Blue Bell PA

Assignee:

McNeil-PPC, Inc. - Skillman NJ

International Classification:

A61K 3306
A61K 3308
A61K 3310
A61K 3312

US Classification:

424687

Abstract:

Calcium carbonate liquid antacid compositions containing one or more pH adjusting agents to maintain the pH above 9. 0, preferably above 9. 5. The resultant antacid liquid possesses superior resistance to microbial attack and enhanced taste properties.

US Patent:

61105058, Aug 29, 2000

Filed:

Apr 1, 1997

Appl. No.:

8/829979

Inventors:

Bruce P. Smith - Blue Bell PA
John J. Dubek - Philadelphia PA
Gerard P. McNally - Strafford PA

Assignee:

McNeil PPC Inc. - New Brunswick NJ

International Classification:

A61K 910
A61K 3310

US Classification:

424686

Abstract:

The invention provides an essentially translucent liquid antacid composition with dihydroxyaluminum sodium carbonate (DASC) as the active ingredient. The DASC is prepared by co-drying DASC with a polyol, and the resulting co-dried DASC/polyol is mixed with water to form the liquid composition. The antacid composition preferably contains additional polyol to further improve the translucency of the liquid composition.