John J Eldridge

US Patent:

8623382, Jan 7, 2014

Filed:

Jan 18, 2011

Appl. No.:

13/008694

Inventors:

Maninder K. Sidhu - New City NY, US
John H. Eldridge - Somers NY, US
Michael Egan - Washingtonville NY, US
Zimra Israel - New York NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 39/21
A61K 39/12

US Classification:

4242081, 4241991

Abstract:

The invention relates to immunogenic compositions for inducing an immune response to HIV comprising combinations of two, three, or four plasmids, where each plasmid is expressing a defined antigen, which may be a single antigen or a fusion of two or three antigens.

US Patent:

20070190031, Aug 16, 2007

Filed:

Jun 15, 2005

Appl. No.:

11/629610

Inventors:

Maninder Sidhu - New City NY, US
John Eldridge - Somers NY, US
Michael Egan - Washingtonville NY, US
Zimra Israel - New York NY, US

International Classification:

A61K 39/21
A61K 48/00
C12N 15/867

US Classification:

424093200, 435456000, 424208100

Abstract:

The invention provides a DNA plasmid comprising: (a) a first transcriptional unit comprising a nucleotide sequence that encodes a first polypeptide operably linked to regulatory elements including a first promoter and a first polyadenylation signal; (b) a second transcriptional unit comprising a nucleotide sequence that encodes a second polypeptide operably linked to regulatory elements including a second promoter and a second polyadenylation signal; (c) a third transcriptional unit comprising a nucleotide sequence that encodes a third polypeptide operably linked to regulatory elements including a third promoter and a third polyadenylation signal; and wherein said first, said second and said third promoters are each derived from different transcriptional units; and wherein said first, said second and said third polyadenylation signals are each derived from different transcriptional units. The invention further relates to immunogenic compositions for inducing an immune response to HIV comprising combinations of two, three, or four plasmids, where each plasmid is expressing a defined antigen, which may be a single antigen or a fusion of two or three antigens.