John A Feild

US Patent:

6350858, Feb 26, 2002

Filed:

Apr 19, 2000

Appl. No.:

09/553132

Inventors:

John Feild - Wayne PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07K 100

US Classification:

530350

Abstract:

IPT-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IPT-1 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, end stage renal disease, uremic bone disease, and cancer, among others, and diagnostic assays for such conditions.

US Patent:

6420544, Jul 16, 2002

Filed:

May 17, 2000

Appl. No.:

09/572147

Inventors:

Harma Ellens - Norristown PA
John Feild - Wayne PA
Lin Yue - Phoenixville PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07H 2104

US Classification:

536 235, 536 231, 435 691, 435 701, 4353201, 435325

Abstract:

Mouse OATP5 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize mouse OATP5. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: cancer, inflammation, cardiovascular disease, central nervous system disorders, auto-immune disease, and kidney and liver disease.

US Patent:

6433156, Aug 13, 2002

Filed:

Dec 22, 1998

Appl. No.:

09/218489

Inventors:

Robert S. Ames - Havertown PA
John A. Feild - Wayne PA
Tania Testa - London, GB

Assignee:

SmithKline Beecham Corporation - PA
SmithKline Beecham plc - Brentford

International Classification:

C07H 2104

US Classification:

536 235, 435 691, 435 701, 435 711, 4353201, 435325, 435455

Abstract:

Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16.

US Patent:

20010012628, Aug 9, 2001

Filed:

Mar 6, 2001

Appl. No.:

09/799776

Inventors:

Pankaj Agarwal - King of Prussia PA, US
Frank Barone - Audubon PA, US
John Feild - Wayne PA, US
Karen Kabnick - Lafayette Hill PA, US
Michael McQueney - Philadelphia PA, US

International Classification:

C12P021/06
C07H021/04
C07K001/00
C07K014/00
C07K017/00
C12P021/08

US Classification:

435/069100, 530/350000, 530/387900, 536/023500

Abstract:

sbgFGF-19a polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing sbgFGF-19a polypeptides and polynucleotides in diagnostic assays.

US Patent:

20020026042, Feb 28, 2002

Filed:

Sep 12, 2001

Appl. No.:

09/950960

Inventors:

Robert Ames - Havertown PA, US
John Feild - Wayne PA, US
Tania Testa - London, GB

International Classification:

C12P021/02
C12N005/06
C07H021/04
C12N009/00

US Classification:

536/023200, 435/183000, 435/325000, 435/320100, 435/069100

Abstract:

Rabbit G alpha 16 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing rabbit G alpha 16 polypeptides and polynucleotides in screening of antagonists or agonists of cells co-expressing a G-protein coupled receptor and rabbit G alpha 16

US Patent:

20020055128, May 9, 2002

Filed:

Jan 25, 2001

Appl. No.:

09/769097

Inventors:

Kimberly Brun - Harleysville PA, US
Richard Chenery - Hitchin, GB
Harma Ellens - Norristown PA, US
John Feild - Wayne PA, US
Lin Yue - Phoenixville PA, US

International Classification:

G01N033/567
C07H021/04
C12N009/00
C12N005/06
C12P021/02

US Classification:

435/007210, 435/183000, 435/069100, 435/325000, 435/320100, 536/023200

Abstract:

Rat mdr1a polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rat mdr1a. Further disclosed is method for performing a selection screen, whereby compounds are discovered that neither agonize nor antagonize rat mdr1a.

US Patent:

20020160492, Oct 31, 2002

Filed:

Jul 25, 2001

Appl. No.:

09/912788

Inventors:

Michael Cook - Drexil Hill PA, US
John Feild - Wayne PA, US

International Classification:

A61K038/48
C07H021/04
C12N009/64
C12P021/02
C12N005/06

US Classification:

435/226000, 424/094630, 435/069100, 435/325000, 435/320100, 536/023200

Abstract:

Bovine aggrecanase-1 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds that either agonize or antagonize bovine aggrecanase-1. Such compounds are expected to be useful in treatment of human diseases, including, but not limited to: osteoarthritis, rheumatoid arthritis, joint injury, reactive and psoriatic arthritis and other diseases of bone.

US Patent:

63196883, Nov 20, 2001

Filed:

Sep 23, 1997

Appl. No.:

8/935433

Inventors:

John Feild - Wayne PA

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C12N 1509
C12N 1512
C12N 500
C12N 510

US Classification:

435 691

Abstract:

IPT-1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing IPT-1 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, end stage renal disease, uremic bone disease, and cancer, among others, and diagnostic assays for such conditions.