John E Glass

US Patent:

6531583, Mar 11, 2003

Filed:

Dec 8, 2000

Appl. No.:

09/601198

Inventors:

Gail H. Cassell - Carmel IN
Ellson Y. Chen - Burlingame CA
Jennifer S. Glass - Indianapolis IN
John I. Glass - Indianapolis IN
Cheryl R. Heiner - La Honda CA
Elliot Lefkowitz - Birmingham AL

Assignee:

UAB Research Foundation, The - Birmingham AL

International Classification:

C07H 1900

US Classification:

536 221, 435 6, 435 71, 435 911, 435 912, 4353201, 536 231, 536 243, 536 2431, 536 2432, 536 2433

Abstract:

A method of detecting a nucleic acid sequence in serovar 3 includes the steps of isolating a specimen containing nucleic acid; and analyzing the specimen with an assay such as in situ hybridization, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification, 5â nuclease assay (TaqMan PCR), and DNA-chip analysis using the nucleic acid sequences SEQ ID Nos:1-181.

US Patent:

20030176654, Sep 18, 2003

Filed:

Jan 23, 2003

Appl. No.:

10/349680

Inventors:

Gail Cassell - Carmel IN, US
Ellson Chen - Burlingame CA, US
Jennifer Glass - Indianapolis IN, US
John Glass - Indianapolis IN, US
Cheryl Heiner - La Honda CA, US
Elliot Lefkowitz - Birmingham AL, US

Assignee:

The UAB Research Foundation - Birmingham AL

International Classification:

C07K014/195
C07H021/04

US Classification:

530/350000, 536/023200

Abstract:

A method of detecting a nucleic acid sequence in serovar 3 includes the steps of isolating a specimen containing nucleic acid; and analyzing the specimen with an assay such as in situ hybridization, Southern blotting, single strand conformational polymorphism, restriction endonuclease fingerprinting (REF), PCR amplification, 5′ nuclease assay (TaqMan PCR), and DNA-chip analysis using the nucleic acid sequences SEQ ID Nos:1-181.

US Patent:

20140294763, Oct 2, 2014

Filed:

Jun 17, 2014

Appl. No.:

14/306778

Inventors:

- Boston MA, US
Shu Hui Chen - Carmel IN, US
Ivan Collado-Cano - Madrid, ES
Maria Cristina Garcia Paredes - Madrid, ES
John Irvin Glass - Indianapolis IN, US
Ling Jin - Carmel IN, US
Jason Eric Lamar - Indianapolis IN, US
Nancy June Snyder - Lizton IN, US
Xicheng David Sun - Superior CO, US
Deqi Guo - Carmel IN, US
Yvonne Yee Mai Yip - Indianapolis IN, US
May Q. Wang - Indianapolis IN, US
Victor Frantz - Indianapolis IN, US
Mark Joseph Tebbe - Hamburg, DE
Robert B. Perni - Marlborough MA, US
Luc J. Farmer - Montreal, CA

International Classification:

C07K 7/02
A61K 38/21
A61K 45/06
C07K 5/103
A61K 38/07
A61K 38/08
C07D 209/52

US Classification:

424 852, 530323, 514 43, 424 854, 424 857, 424 856, 435184, 435375

Abstract:

The present invention relates to peptidomimetic compounds useful as protease inhibitors, particularly as serine protease inhibitors and more particularly as hepatitis C NS3 protease inhibitors; intermediates thereto; their preparation including novel steroselective processes to intermediates. The invention is also directed to pharmaceutical compositions and to methods for using the compounds for inhibiting HCV protease or treating a patient suffering from an HCV infection or physiological condition related to the infection. Also provided are pharmaceutical combinations comprising, in addition to one or more HCV serine protease inhibitors, one or more interferons exhibiting anti-HCV activity and/or one or more compounds having anti HCV activity and a pharmaceutically acceptable carrier, and methods for treating or preventing a HCV infection in a patient using the compositions. The present invention is also directed to a kit or pharmaceutical pack for treating or preventing HCV infection in a patient.