John R Glisson

US Patent:

6495661, Dec 17, 2002

Filed:

Jul 21, 1998

Appl. No.:

09/120051

Inventors:

John Robert Glisson - Watkinsville GA
Yugang Luo - Millsboro DE

Assignee:

University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

C07K 400

US Classification:

530300, 530317, 530325, 530326, 530350, 930200, 930270

Abstract:

An isolated nucleic acid molecule encoding the outer membrane protein of is provided. Also provided are methods to detect the presence of the nucleic acid molecule, and antibodies specific for the polypeptide encoded by the nucleic acid molecule, in a sample. Further provided are immunogenic compositions comprising the outer membrane polypeptide or protien of , or portions thereof.

US Patent:

49991914, Mar 12, 1991

Filed:

May 5, 1988

Appl. No.:

7/190533

Inventors:

John R. Glisson - Athens GA
Charles L. Hofacre - Monroe NC

Assignee:

University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

A61K 3902
C12N 1500

US Classification:

424 92

Abstract:

Mutogenesis of the Clemson University (CU) vaccine strain of P. multocida with N-methyl-N-nitro-N-nitrosoguanidine resulted in temperature sensitive (TS) mutants which grew at 37. degree. C. but not 42. degree. C. Two mutants, PM#1 and PM#3, were found to provide turkeys with a level of protection against challenge with a virulent serotype 3 P. multocida strain (P-1059) comparable to the protection provided by the CU strain. Intravenous (IV) inoculation of PM#1, PM#3, and CU was used to determine differences in virulence. PM#1 and PM#3 resulted in lower mortality and lameness than the CU strain. Histopathological evaluation of spleens at 24, 48, and 72 hours post IV inoculation demonstrated that the CU strain induced 2 times more splenic necrosis than either PM#1 or PM#3.

US Patent:

51185024, Jun 2, 1992

Filed:

Jun 20, 1989

Appl. No.:

7/369071

Inventors:

John R. Glisson - Athens GA
Pedro Villegas - Athens GA

Assignee:

The University of Georgia Research Foundation, Inc. - Athens GA

International Classification:

A61K 3912
C12N 700

US Classification:

424 89

Abstract:

A Newcastle disease vaccine and method of using the vaccine for protecting a poultry animal from Newcastle disease is provided. The vaccine consists of a naturally attenuated live Newcastle disease virus which has the identifying characteristics of ATCC No. VR 2239. The vaccine is capable of conferring solid immunity against Newcastle disease and causes minimal respiratory or other undesirable reactions in inoculated animals.