John Robert Greene

Address:

7915 Mandan Rd APT 301, Greenbelt, MD 20770

VIN:

1A8HW582X7F571726

Make:

CHRYSLER

Model:

ASPEN

Year:

2007

US Patent:

6368822, Apr 9, 2002

Filed:

Mar 9, 1998

Appl. No.:

09/036985

Inventors:

John M. Greene - Gaithersburg MD
Joachim R. Gruber - Gaithersburg MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12P 2106

US Classification:

435 691, 435 6, 4353201, 435325, 435 694, 435 697, 536 235

Abstract:

Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

US Patent:

6391853, May 21, 2002

Filed:

Mar 4, 1999

Appl. No.:

09/262087

Inventors:

John M. Greene - Gaithersburg MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3857

US Classification:

514 12, 435226

Abstract:

A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.

US Patent:

6403557, Jun 11, 2002

Filed:

Nov 21, 1997

Appl. No.:

08/976315

Inventors:

John M. Greene - Gaithersburg MD
Joachim R. Gruber - Dallas TX
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 3818

US Classification:

514 12, 530350, 530399, 514 2

Abstract:

The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.

US Patent:

6420526, Jul 16, 2002

Filed:

Sep 8, 1998

Appl. No.:

09/149476

Inventors:

Steven M. Ruben - Olney MD
Craig A. Rosen - Laytonsville MD
Carrie L. Fischer - Burke VA
Daniel P. Soppet - Centreville VA
Kenneth C. Carter - North Potomac MD
Daniel R. Bednarik - Columbia MD
Gregory A. Endress - Potomac MD
Guo-Liang Yu - Berkeley CA
Jian Ni - Rockville MD
Ping Feng - Gaithersburg MD
Paul E. Young - Gaithersburg MD
John M. Greene - Gaithersburg MD
Ann M. Ferrie - Tewksbury MA
Roxanne Duan - Bethesda MD
Jing-Shan Hu - Sunnyvale CA
Kimberly A. Florence - Rockville MD
Henrik S. Olsen - Gaithersburg MD
Reinhard Ebner - Gaithersburg MD
Laurie A. Brewer - St. Paul MN
Paul A. Moore - Germantown MD
Yanggu Shi - Gaithersburg MD
David W. Lafleur - Washington DC
Yi Li - Sunnyvale CA
Zhizhen Zeng - Lansdale PA
Hla Kyaw - Frederick MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12Q 168

US Classification:

530350, 435 6, 536 231

Abstract:

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

US Patent:

6448042, Sep 10, 2002

Filed:

Jun 5, 1995

Appl. No.:

08/463261

Inventors:

John M. Greene - Gaithersburg MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 1515

US Classification:

435 692, 435 691, 435 9141, 4352523, 435325, 4353201, 435440, 536 235, 536 231

Abstract:

A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.

US Patent:

6482408, Nov 19, 2002

Filed:

Oct 25, 1999

Appl. No.:

09/425021

Inventors:

John M. Greene - Gaithersburg MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

A61K 39395

US Classification:

4241301, 4241331, 4241391, 4241411, 4241451, 5303871, 5303873, 5303879, 5303881, 53038815, 53038824, 530399

Abstract:

The present invention relates to antibodies directed to the human protein called Fibroblast Growth Factor 15.

US Patent:

6525174, Feb 25, 2003

Filed:

Dec 4, 1998

Appl. No.:

09/205258

Inventors:

Paul Young - Gaithersburg MD
John M. Greene - Gaithersburg MD
Ann M. Ferrie - Tewksbury MA
Steven M. Ruben - Olney MD
Craig A. Rosen - Laytonsville MD
Jing-Shan Hu - Sunnyvale CA
Henrik S. Olsen - Gaithersburg MD
Reinhard Ebner - Gaithersburg MD
Laurie A. Brewer - St. Paul MN
Paul A. Moore - Germantown MD
Yanggu Shi - Gaithersburg MD
Charles Florence - Rockville MD
Kimberly Florence - Rockville MD
David W. Lafleur - Washington DC
Jian Ni - Rockville MD
Ping Fan - Gaithersburg MD
Ying-Fei Wei - Berkeley CA
Carrie L. Fischer - Burke VA
Daniel R. Soppet - Centreville VA
Yi Li - Sunnyvale CA
Zhizhen Zeng - Gaithersburg MD
Hla Kyaw - Frederick MD
Guo-Liang Yu - Berkeley CA
Ping Feng - Gaithersburg MD
Patrick J. Dillon - Carlsbad CA
Gregory A. Endress - Potomac MD
Kenneth C. Carter - North Potomac MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C07K 1447

US Classification:

530350, 435 691, 514 2

Abstract:

The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

US Patent:

6544761, Apr 8, 2003

Filed:

Jul 11, 2001

Appl. No.:

09/901904

Inventors:

John M. Greene - Gaithersburg MD
Craig A. Rosen - Laytonsville MD

Assignee:

Human Genome Sciences, Inc. - Rockville MD

International Classification:

C12N 1515

US Classification:

435 692, 530350, 514 12, 536 235

Abstract:

A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.