John G Hanrahan

US Patent:

20110250242, Oct 13, 2011

Filed:

Oct 22, 2009

Appl. No.:

13/125506

Inventors:

Holly Huang - Northborough MA, US
Elizabeth B. Goodwin - Upton MA, US
Kendyl M. Schaefer - Dedham MA, US
John P. Hanrahan - West Roxbury MA, US
William T. Andrews - Hopkinton MA, US
Paul Mcglynn - Northborough MA, US

Assignee:

SUNOVION PHARMACEUTICALS INC. - Marlborough MA

International Classification:

A61K 9/00
A61P 11/06
A61P 11/08
A61K 31/439
A61P 11/00

US Classification:

424400, 514291

Abstract:

Compositions and methods for the prevention and/or treatment of airway and/or respiratory disorders are provided. The compositions comprise arformoterol (the (R,R)-formoterol isomer) and tiotropium.

US Patent:

20120058198, Mar 8, 2012

Filed:

Mar 26, 2010

Appl. No.:

13/259615

Inventors:

Robert W. Clarke - Medfield MA, US
Richard Batycky - Newton MA, US
Wesley H. Dehaan - Chelmsford MA, US
David L. Hava - Natick MA, US
Michael M. Lipp - Framingham MA, US
John Hanrahan - West Roxbury MA, US

Assignee:

PULMATRIX, INC. - Lexington MA

International Classification:

A61P 31/04
A61K 33/06
A61K 33/14

US Classification:

424602, 424680, 424682, 424687, 514557

Abstract:

The invention relates to methods for treating bacterial infection of the respiratory tract, including pneumonias, such as ventilator-associated pneumonia, and to methods for treating ventilator-associated tracheobronchitis, comprising administering an effective amount of a salt formulation as an aerosol to the respiratory tract of an individual in need thereof. The formulations can also be used to reduce transmission of pathogen which can infect the respiratory tract, cause pneumonia or cause ventilator-associated tracheobronchitis.

US Patent:

20120107414, May 3, 2012

Filed:

Mar 26, 2010

Appl. No.:

13/259651

Inventors:

Michael M. Lipp - Framingham MA, US
Robert W. Clarke - Medfield MA, US
David L. Hava - Natick MA, US
Richard Batycky - Newton MA, US
John Hanrahan - West Roxbury MA, US

Assignee:

Pulmatrix, Inc. - Lexington MA

International Classification:

A61K 33/42
A61K 33/10
A61K 33/06
A61K 33/00
A61K 33/04
A61K 33/22
A61K 31/19
A61K 31/734
A61K 31/20
A61K 31/191
A61K 31/194
A61K 31/375
A61K 31/192
A61P 31/00
A61K 33/14

US Classification:

424602, 424678, 424687, 424696, 424680, 424717, 424715, 424709, 424606, 424711, 424660, 424600, 514557, 514 54, 514558, 514574, 514474, 514568

Abstract:

The present invention relates to pharmaceutical formulations for treating a respiratory tract infection or a pulmonary disease in an individual, comprising a calcium salt and a sodium salt, wherein the ratio of Cato Na is from about 4:1 (mole:mole) to about 16:1 (mole:mole). The invention also relates to methods of treating (including prophylactically treating) and reducing the spread of a respiratory tract infection, methods of treating (including prophylactically treating) a pulmonary disease or an acute exacerbation of a pulmonary disease, and methods of reducing the spread of an acute exacerbation of a pulmonary disease, comprising administering a pharmaceutical formulation that comprises a calcium salt and a sodium salt.

US Patent:

20140336159, Nov 13, 2014

Filed:

Oct 5, 2012

Appl. No.:

14/350235

Inventors:

- Lexington MA, US
David L. Hava - Natick MA, US
John P. Hanrahan - West Roxbury MA, US
Wesley Hugh Dehaan - Chelmsford MA, US
Paulette Wright Andreotta - Charlton MA, US
Stephen P. Arold - Billerica MA, US
Jennifer Kenyon Saunders - Boston MA, US

International Classification:

A61K 31/19
A61K 9/00
A61K 31/56
A61K 45/06

US Classification:

514171, 514557

Abstract:

Described are methods of preventing, treating and diagnosing of a subject having a condition, such as, an inflammation or infection of the respiratory tract. Methods of treatment and prevention include administration of effective amounts of calcium salt formulations to a subject. Methods of diagnosing include the use of biomarkers and optionally the use of kits that can detect biomarkers. Further described are methods for modulating an immune response that include the modulation of Toll-like receptors.

US Patent:

20140336218, Nov 13, 2014

Filed:

Jul 25, 2014

Appl. No.:

14/340736

Inventors:

- Marlborough MA, US
Elizabeth B. GOODWIN - Upton MA, US
Kendyl M. SCHAEFER - Dedham MA, US
John P. HANRAHAN - West Roxbury MA, US
William T. ANDREWS - Hopkinton MA, US
Paul MCGLYNN - Northborough MA, US

Assignee:

SUNOVION PHARMACEUTICALS INC. - Marlborough MA

International Classification:

A61K 31/46
A61K 9/00
A61K 31/137

US Classification:

514304

Abstract:

Compositions and methods for the prevention and/or treatment of airway and/or respiratory disorders are provided. The compositions comprise arformoterol (the (R,R)-formoterol isomer) and tiotropium.

US Patent:

20140134251, May 15, 2014

Filed:

Oct 23, 2013

Appl. No.:

14/061006

Inventors:

- Lexington MA, US
Robert W. CLARKE - Medfield MA, US
David L. HAVA - Natick MA, US
Richard BATYCKY - Newton MA, US
John HANRAHAN - West Roxbury MA, US

Assignee:

PULMATRIX, INC. - Lexington MA

International Classification:

A61K 33/14
A61K 33/42
A61K 33/06
A61K 33/10
A61K 31/20
A61K 45/06
A61K 9/00
A61K 31/734
A61K 31/194
A61K 31/19
A61K 33/00
A61K 33/04

US Classification:

424489, 424722, 424602, 424606, 424717, 424660, 424678, 424680, 424687, 424696, 424709, 514 54, 514574, 514557, 514558

Abstract:

The present invention relates to pharmaceutical formulations for treating a respiratory tract infection or a pulmonary disease in an individual, comprising a calcium salt and a sodium salt, wherein the ratio of Cato Na is from about 4:1 (mole:mole) to about 16:1 (mole:mole). The invention also relates to methods of treating (including prophylactically treating) and reducing the spread of a respiratory tract infection, methods of treating (including prophylactically treating) a pulmonary disease or an acute exacerbation of a pulmonary disease, and methods of reducing the spread of an acute exacerbation of a pulmonary disease, comprising administering a pharmaceutical formulation that comprises a calcium salt and a sodium salt.