John J Healey

US Patent:

6547777, Apr 15, 2003

Filed:

Feb 16, 2001

Appl. No.:

09/784132

Inventors:

Gene R. DiResta - Pleasantville NY
John Henry Healey - New York NY

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

A61M 3100

US Classification:

604506, 604501

Abstract:

An apparatus, system, and method are provided for reducing interstitial fluid pressure in tissue, particularly in tumors. The apparatus includes an aspiration probe with at least one slit along its body to provide fluid communication between the aspiration probe and the tissue. Suction in the chamber of the aspiration probe generated by a suction source reduces the interstitial fluid pressure. Compared to prior art devices, the geometry of the slit of the aspiration probe is less likely to become blocked. The present invention also includes a cleaning obturator to unclog the slit and a blocking obturator to prevent accumulation of tissue in the aspiration probe chamber when suction is off. The blocking obturator can be made of a number of biocompatible materials, including a material impregnated with a pharmacological agent. In order to enhance delivery of the pharmacological agent or any drug, the present invention also includes a conducting obturator made of an electrically conductive material to serve as an electroporation electrode. In one embodiment, at least a portion of the aspiration probe is made of an electrically conductive material and serves as an electroporation electrode.

US Patent:

7422893, Sep 9, 2008

Filed:

Mar 3, 2003

Appl. No.:

10/378585

Inventors:

Gene R. Diresta - Pleasantville NY, US
John H. Healey - New York NY, US
Robert Schwar - Forestburgh NY, US

Assignee:

Memorial Sloan-Kettering Cancer Center - New York NY

International Classification:

C12M 1/00
C12M 3/00

US Classification:

4352891, 435325, 4352831, 4353041, 4353051

Abstract:

An apparatus for growing cells in a 2-D cell cassette having a matrix for cell growth under pressure comprising two side assemblies which include a frame with a rigid support that fits over the 2-D cell cassette, with said assemblies positioned on either side of the cassette over the solid support sides, and a means to secure the sides of the cassette. The invention also provides different uses of this apparatus.

US Patent:

7435587, Oct 14, 2008

Filed:

Dec 20, 2004

Appl. No.:

11/018094

Inventors:

Gene R. Diresta - Pleasantville NY, US
John H. Healey - New York NY, US
Robert Schwar - Forestburgh NY, US

Assignee:

Memorial Sloan-Kettering Cancer Center - New York NY

International Classification:

C12N 5/02

US Classification:

435325, 4352831, 4352891, 4353041, 4353051

Abstract:

This invention provides an apparatus for growing cells under static or dynamic physiological pressure which contains a cell culture cassette having a cassette frame; two side walls secured to each side of the cassette frame to form a cell growing chamber, and at least one side wall comprises a cell growth surface. The apparatus also contains a means for adjusting fluid pressure or flow, for providing culture media or cell culture, or for sampling cell culture or culture media within the cell growing chamber. The apparatus further contains an adapter which contains two side assemblies where each side assembly includes a frame with a rigid support that fits over the cell culture cassette. The side assemblies joined by a hinge at one end and positioned over the two side walls of the cell culture cassette. The apparatus further contains a means to secure the two side assemblies over the two side walls of the cell culture cassette.

US Patent:

D687987, Aug 13, 2013

Filed:

May 1, 2012

Appl. No.:

29/419764

Inventors:

Bruce Ancona - New York NY, US
Louis F. Henry - Scarsdale NY, US
John Healey - Brooklyn NY, US

Assignee:

Blackbeam LLC - New York NY

International Classification:

2602

US Classification:

D26 46

US Patent:

20030149407, Aug 7, 2003

Filed:

Feb 24, 2003

Appl. No.:

10/372435

Inventors:

Gene DiResta - Pleasantville NY, US
John Healey - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research

International Classification:

A61M001/00
A61M027/00

US Classification:

604/313000, 604/541000, 604/319000, 604/326000

Abstract:

An apparatus, system, and method are provided for reducing interstitial fluid pressure in tissue, particularly in tumors. The apparatus includes an aspiration probe with at least one slit along its body to provide fluid communication between the aspiration probe and the tissue. Suction in the chamber of the aspiration probe generated by a suction source reduces the interstitial fluid pressure. Compared to prior art devices, the geometry of the slit of the aspiration probe is less likely to become blocked. The present invention also includes a cleaning obturator to unclog the slit and a blocking obturator to prevent accumulation of tissue in the aspiration probe chamber when suction is off. The blocking obturator can be made of a number of biocompatible materials, including a material impregnated with a pharmacological agent. In order to enhance delivery of the pharmacological agent or any drug, the present invention also includes a conducting obturator made of an electrically conductive material to serve as an electroporation electrode. In one embodiment, at least a portion of the aspiration probe is made of an electrically conductive material and serves as an electroporation electrode.

US Patent:

20080286377, Nov 20, 2008

Filed:

Jun 9, 2008

Appl. No.:

12/135484

Inventors:

John H. Healey - New York City NY, US
Gene R. DiResta - Yonkers NY, US

International Classification:

A61K 9/14
A61K 31/683

US Classification:

424501, 514108

Abstract:

Anti-resorptive bone cements, comprising an anti-resorptive amount of one or more anti-resorptive agents, preferably the anti-resorptive agent is a bisphosphonate. The anti-resorptive bone cements are useful for reducing bone voids and bonding prosthetic devices to bone. The invention also relates to anti-resorptive allogeneic, autografic, and xenografic bone grafts, which bone grafts comprise an anti-resorptive amount of an anti-resorptive agent such as a bisphosphonate. The anti-resorptive bone grafts are useful for reconstructive bone surgery.