John C Herrmann

US Patent:

20210380670, Dec 9, 2021

Filed:

Aug 13, 2021

Appl. No.:

17/402329

Inventors:

- Cambridge MA, US
Ilaria Lamberto - Arlington MA, US
Seng-Lai Tan - Sudbury MA, US
Jonathan Hsu - Waltham MA, US
Brian Edward Vash - Cambridge MA, US
Nidhi Malhotra - Boston MA, US
Madan Katragadda - Acton MA, US
John Leonard Herrmann - Winchester MA, US
Stephanie J. Maiocco - Arlington MA, US

International Classification:

C07K 16/18
C07K 16/28
A61K 39/395
A61P 35/00

Abstract:

Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

US Patent:

20210238280, Aug 5, 2021

Filed:

Mar 14, 2019

Appl. No.:

16/980730

Inventors:

- Cambridge MA, US
Ilaria Lamberto - Arlington MA, US
John Leonard Herrmann - Winchester MA, US
Brian Edward Vash - Cambridge MA, US

International Classification:

C07K 16/28

Abstract:

Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin mutant protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or a modulator of a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

US Patent:

20210009711, Jan 14, 2021

Filed:

Mar 14, 2019

Appl. No.:

16/980771

Inventors:

- Cambridge MA, US
Ilaria Lamberto - Arlington MA, US
John Leonard Herrmann - Winchester MA, US
Brian Edward Vash - Cambridge MA, US

International Classification:

C07K 16/30
A61K 45/06
A61K 39/395
C07K 16/28
C07K 14/54
C07K 14/57
C07K 14/71
C12N 9/26
C12N 9/50

Abstract:

Multispecific molecules that include a first tumor-targeting moiety; a second tumor-targeting moiety; and one, two or all of: an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); a cytokine molecule or a modulator of a cytokine molecule; and/or a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.