John H Higgins

US Patent:

D603156, Nov 3, 2009

Filed:

Mar 3, 2008

Appl. No.:

29/301429

Inventors:

John Higgins - Nashua NH, US

International Classification:

0301

US Classification:

D 32031

US Patent:

20050056564, Mar 17, 2005

Filed:

Sep 16, 2003

Appl. No.:

10/663931

Inventors:

John Higgins - Nashua NH, US

International Classification:

B65D083/04

US Classification:

206534000, 206459500, 206528000

Abstract:

A personal wallet pill card comprising a card like configuration that provides transportation, easy access storage, and a method to protect the medication from harm while transported in a wallet. This is achieved by utilizing the top upper pocket section of a wallet; where there is the only open space, allowing the storage without making the wallet thicker or applying pressure to the oral medications.

US Patent:

20100170796, Jul 8, 2010

Filed:

Feb 8, 2008

Appl. No.:

12/525752

Inventors:

Sangeeta N. Bhatia - Lexington MA, US
David T. Eddington - Wheaton IL, US
John M. Higgins - Cambridge MA, US
Lakshminarayanan Mahadevan - Brookline MA, US

Assignee:

MASSACHUSETTS INSTITUTE OF TECHNOLOGY - CAMBRIDGE MA
PRESIDENT AND FELLOWS OF HARVARD COLLEGE OFFICE OF - CAMBRIDGE MA

International Classification:

G01N 27/26
G01N 27/447

US Classification:

204453, 204601

Abstract:

One aspect of the invention relates to a microfluidic device which recreates important features of the human microcirculation on a microscope stage. In certain embodiments of the invention, the clinical scenario associated with ‘sickle cell crisis’ whereby blood vessels are occluded in various organs causing pain and tissue damage can be recreated. In certain embodiments, one can use a device of the invention to study the processes that lead to crisis, and screen therapies (such as small molecules) that might be used to prevent crisis. Further, certain embodiments of the invention allow one to study and screen therapies for a range of human blood disorders, such as hereditary spherocytosis, disorders of white blood cells, such as Waldenstrom's macroglobulinemia or leukocytosis, disorders of blood platelets and coagulation, such as hemophilia A and B, activated protein C resistance, and essential thrombocythemia.

US Patent:

20130236566, Sep 12, 2013

Filed:

Sep 16, 2011

Appl. No.:

13/823338

Inventors:

John M. Higgins - Cambridge MA, US

Assignee:

THE GENERAL HOSPITAL CORPORATION - Boston MA

International Classification:

C12Q 1/02

US Classification:

424646, 435 29

Abstract:

Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several weeks before anemia becomes clinically detectable. Also, methods for detecting blood doping in athletes and for optimizing therapy with erythropoiesis stimulating agents or iron supplementation. Computer-readable storage devices and systems, e.g., for use in the described methods.

US Patent:

57924449, Aug 11, 1998

Filed:

Oct 22, 1993

Appl. No.:

8/140000

Inventors:

Alan J. Fischman - Boston MA
Howard F. Solomon - New Hope PA
Claudia K. Derian - Hatboro PA
Gary J. Bridger - Bryn Mawr PA
John D. Higgins - West Chester PA
Scott K. Larsen - West Chester PA
Pedro E. Hernandez - Malvern PA
Robert H. Rubin - Brookline MA
H. William Strauss - Skillman NJ
Anthony J. Fuccello - Princeton NJ
Daniel J. Kroon - Flemington NJ

Assignee:

The General Hospital Corporation - Boston MA
Johnson Matthey, Inc. - West Chester PA
Ortho Pharmaceutical Corporation - Raritan NJ

International Classification:

A61K 5108
A61K 3700

US Classification:

424 169

Abstract:

The invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure X--Y--Leu--Phe--�Z!. sub. n --W wherein: X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.

US Patent:

46620958, May 5, 1987

Filed:

Jul 8, 1985

Appl. No.:

6/752557

Inventors:

John R. Higgins - Concord MA

International Classification:

G09F 1316

US Classification:

40592

Abstract:

A foldable sign capable of being mounted on the roof of a vehicle. The foldable sign has a sign plate pivotally mounted upon a base which may be removably or fixedly secured to the roof of the vehicle. Interconnected between the sign plate and the base is a latching mechanism capable of securely locking the sign plate at two portions thereof in either an upright (unfolded) position or a horizontal (folded) position with respect to the base. The latching mechanism includes a movable rod which enables an individual with a single sliding movement of the rod to simultaneously disengage the latching mechanism from both portions of the sign plate. In so doing, it is possible to maintain a positive locking of the sign plate in either the upright or retracted positions while enabling a quick release of the locking action to be effected when desired.

US Patent:

20210208167, Jul 8, 2021

Filed:

Mar 19, 2021

Appl. No.:

17/207020

Inventors:

- Boston MA, US
John M. Higgins - Cambridge MA, US
David M. Nathan - West Newton MA, US

International Classification:

G01N 33/72
G01N 33/555

Abstract:

A method includes estimating a value of a parameter indicative of an age or lifespan of a population of red blood cells of a subject, estimating a value of average glucose (AG) of the subject based on (i) the value of the parameter and (ii) a value indicative of an amount of glycated hemoglobin (HbA1c) of the subject, and providing information for treatment or diagnosis of a hyperglycemia condition of the subject based on the estimated value of AG.

US Patent:

20180364262, Dec 20, 2018

Filed:

Dec 15, 2016

Appl. No.:

16/061951

Inventors:

- Boston MA, US
John M. Higgins - Cambridge MA, US
David M. Nathan - West Newton MA, US

International Classification:

G01N 33/72
G01N 33/555

Abstract:

A method includes estimating a value of a parameter indicative of an age or lifespan of a population of red blood cells of a subject, estimating a value of average glucose (AG) of the subject based on (i) the value of the parameter and (ii) a value indicative of an amount of glycated hemoglobin (HbA1c) of the subject, and providing information for treatment or diagnosis of a hyperglycemia condition of the subject based on the estimated value of AG.