John J Huang

US Patent:

8492334, Jul 23, 2013

Filed:

Jun 18, 2008

Appl. No.:

12/664792

Inventors:

Erin Lavik - Branford CT, US
Young H. Kwon - Iowa City IA, US
Markus Kuehn - Amana IA, US
Sandeep Saluja - Fair Lawn NJ, US
James Bertram - New Haven CT, US
John Huang - Hamden CT, US

Assignee:

Yale University - New Haven CT
University of Iowa Research Foundation - Iowa City IA

International Classification:

A61K 38/18
A61K 38/22
A61K 31/7036
A61K 31/704
A61K 31/57
A61K 31/573

US Classification:

514 76, 514 97, 514 36, 514 37, 514300

Abstract:

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing one or more diseases or disorders of the eye, and methods of making and using thereof, are described. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (IOP) in the eye. Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time.

US Patent:

20110206773, Aug 25, 2011

Filed:

Nov 12, 2010

Appl. No.:

12/945246

Inventors:

Erin Lavik - Cleveland Heights OH, US
James Bertram - New Haven CT, US
Sandeep Saluja - Fair Lawn NJ, US
Markus Kuehn - Amana IA, US
Young H. Kwon - Iowa City IA, US
Rebecca Robinson - East Point GA, US
John J. Huang - Hamden CT, US

International Classification:

A61K 9/14
A61K 31/573
A61K 31/216
A61K 31/517
A61P 27/02
B65D 69/00

US Classification:

424501, 424489, 514179, 514180, 514530, 5142664, 206223

Abstract:

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye.

US Patent:

20160101054, Apr 14, 2016

Filed:

Apr 28, 2014

Appl. No.:

14/263566

Inventors:

- New Haven CT, US
- Iowa City IA, US
SANDEEP SALUJA - FAIR LAWN NJ, US
MARKUS KUEHN - AMANA IA, US
JOHN J. HUANG - HAMDEN CT, US
REBECCA ROBINSON - EAST POINT GA, US
YOUNG H. KWON - IOWA CITY IA, US

International Classification:

A61K 9/16
A61K 31/517
A61K 31/216
A61K 31/57
A61K 31/519

Abstract:

Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (IOP) in the eye.