Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, the proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
Proaerolysin Containing Protease Activation Sequences And Methods Of Use For Treatment Of Prostate Cancer
Samuel R. Denmeade - Ellicott City MD, US John T. Isaacs - Phoenix MD, US J. Thomas Buckley - Victoria, CA
Assignee:
University of Victoria Innovation and Development Corporation - Victoria, BC The Johns Hopkins University - Baltimore MD
International Classification:
A61K 38/16 C07K 14/195 C07K 19/00 C12N 15/62
US Classification:
435 697, 514 2, 536 234, 536 237
Abstract:
Disclosed herein are modified proaerolysin (PA) peptide. In some examples, the proteins include a prostate-specific protease cleavage site and can further include a prostate-tissue-specific binding domain which functionally replaces the native PA binding domain. In other examples, the proteins include a furin cleavage site and a prostate tissue-specific binding domain which functionally replaces the native PA binding domain. Methods of using such peptides to treat prostate cancer are also disclosed.
Methods And Compositions For The Detection Of Cancer
Various embodiments of this invention relate generally to targeted activation and delivery of therapeutic drugs to cells that produce prostate specific antigen (PSA), prostate specific membrane antigen (PSMA) or human glandular kallikrein (hK2). Various further embodiments relate more specifically to PSMA-specific peptide prodrugs that become activated to yield therapeutic drugs. Further aspects of various embodiments of the present invention also relate to methods and compositions for treating or preventing cancers and methods and compositions for detecting and/or imaging cancers.
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Fayette Central Elementary School Connersville IN 1981-1984, Milton Elementary School Milton IN 1984-1988, Lincoln Middle School Cambridge City IN 1988-1990
Other member of the 2015 class, previously announced through special committees, include players John Isaacs and Louie Dampier, Australian coach Lindsay Gaze, former player and Boston Celtics coach Tom Heinsohn, and George Raveling, a former coach, commentator and Nike Inc. executive.
Date: Apr 07, 2015
Category: Sports
Source: Google
Former Sixer Mutombo elected to Basketball Hall of Fame
aywood and Jo Jo White, University of Kentucky men's basketball coach John Calipari whose team lost to Wisconsin in the Final Four on Saturday, former WNBA star Lisa Leslie, longtime referee Dick Bavetta, ex-Kentucky and ABA star Louis Dampier, Australian player and coach Lindsay Gaze and John Isaacs
and former college coach and television commentator George Raveling also were elected along with Australian coach and player Lindsay Gaze. And John Isaacs, a star pro player before the NBA was formed, will be inducted posthumously as the representative of the early African-American pioneers committee.
coach John Calipari, ex-Celtics guard Jo Jo White and Lisa Leslie, one of the greats from the women's game, were also elected as part of the Class of 2015 with the five inductees announced at All-Star weekend in February: Louie Dampier (ABA committee), George Raveling (Contributor), the late John Isaacs
Date: Apr 07, 2015
Category: Sports
Source: Google
Native St. Louisan White heads to Basketball Hall of Fame
Others selected were former college coach George Raveling and Australian coach and player Lindsay Gaze. John Isaacs, a star pro player before the NBA was formed, will be inducted posthumously as the representative of the early African-American pioneers committee.
Date: Apr 07, 2015
Category: Sports
Source: Google
John Calipari didn't win the title, but at least he's now a Hall of Famer
That group includes Louie Dampier, who was voted in by the American Basketball Association Committee; John Isaacs, who was voted in by the Early African American Pioneers Committee; Lindsay Gaze, who was voted in by the International Committee; Tom Heinsohn, who was voted in by the Veterans Committ
Date: Apr 06, 2015
Category: Sports
Source: Google
Calipari, Mutombo, Leslie among 2015 Hall of Fame inductees
They include Louie Dampier from the American Basketball Association Committee, John Isaacs from the Early African-American Pioneers Committee, Lindsay Gaze from the International Committee, former Celtics coach Tom Heinsohn from the Veterans Committee and former college coach George Raveling from t
Date: Apr 06, 2015
Source: Google
John Calipari among stars elected to Naismith Hall of Fame
schools to the Final Four UMass, Memphis and Kentucky joined 10 others elected during an announcement ceremony Monday. Others inductees were Jo Jo White, George Raveling, Dikembe Mutombo, Spencer Haywood, Louis Dampier, referee Dick Bavetta, Lisa Leslie, Tom Heinsohn, Lindsay Gaze and John Isaacs.
Date: Apr 06, 2015
Category: Sports
Source: Google
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