John T Lyons

US Patent:

20010006975, Jul 5, 2001

Filed:

Jan 8, 2001

Appl. No.:

09/755060

Inventors:

Jill Wood - Hamden CT, US
Hanno Wild - Wuppertal, DE
Daniel Rogers - San Diego CA, US
John Lyons - Moraga CA, US
Michael Katz - Wallingford CA, US
Yolanda Caringal - Branford CT, US
Robert Dally - Gast Haven CT, US
Wendy Lee - Hamden CT, US
Roger Smith - Madison CT, US
Cheri Blum - Alameda CA, US

Assignee:

BAYER CORPORATION and ONYX PHARMACEUTICALS West Haven, CT and Richmond, CA, respectively

International Classification:

A61K031/38
C07D409/00
C 07D 3 7/02
C07D333/42

US Classification:

514/363000, 514/371000, 514/397000, 514/407000, 514/414000, 514/444000, 548/140000, 548/196000, 548/315100, 548/365700, 548/465000, 549/059000, 549/069000, 549/480000

Abstract:

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

US Patent:

20050256174, Nov 17, 2005

Filed:

Jun 10, 2005

Appl. No.:

11/149332

Inventors:

Jill Wood - Hamden CT, US
Hanno Wild - Wuppertal, DE
Daniel Rogers - San Diego CA, US
John Lyons - Moraga CA, US
Michael Katz - Wallingford CT, US
Yolanda Caringal - Bran Ford CT, US
Robert Dally - East Haven CT, US
Wendy Lee - Hamden CT, US
Roger Smith - Madison CT, US
Cheri Blum - Alameda CA, US

International Classification:

A61K031/433
A61K031/416
A61K031/381

US Classification:

514362000, 514406000, 514444000, 514447000

Abstract:

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

US Patent:

20100063088, Mar 11, 2010

Filed:

Nov 17, 2009

Appl. No.:

12/619878

Inventors:

Jill E. WOOD - Hamden CT, US
Hanno Wild - Wuppertal, DE
Daniel H. Rogers - San Diego CA, US
John Lyons - Moraga CA, US
Michael Katz - Wallingford CT, US
Yolanda Caringal - Branford CT, US
Robert Dally - East Haven CT, US
Wendy Lee - Hamden CT, US
Roger A. Smith - Madison CT, US
Cheri Blum - Alameda CA, US

International Classification:

A61K 31/381
A61P 35/00
A61K 31/433
A61K 31/4155
A61K 31/404
A61K 31/427
A61K 31/4025
A61K 31/40
A61K 31/341
A61K 31/437
C07D 333/36
C07D 417/12
C07D 409/12
C07D 307/68
C07D 471/04

US Classification:

514303, 514447, 514363, 514407, 514414, 514371, 514422, 514423, 514472, 549 69, 548140, 549 59, 548465, 548196, 548527, 549480, 546119

Abstract:

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

US Patent:

20120178780, Jul 12, 2012

Filed:

Mar 19, 2012

Appl. No.:

13/424111

Inventors:

Jill E. WOOD - Hamden CT, US
Hanno Wild - Wuppertal, DE
Daniel H. Rogers - San Diego CA, US
John Lyons - Moraga CA, US
Michael Katz - Wallingford CT, US
Yolanda Caringal - Branford CT, US
Robert Dally - East Haven CT, US
Wendy Lee - Hamden CT, US
Roger A. Smith - Madison CT, US
Cheri Blum - Alameda CA, US

International Classification:

A61K 31/381
A61K 31/4155
A61K 31/437
A61K 31/34
A61K 31/40
A61K 31/404
A61K 31/427
A61K 31/4025
C07D 333/38
C07D 417/12
C07D 409/12
C07D 307/68
C07D 207/34
C07D 471/04
A61P 35/00
A61K 31/433

US Classification:

514303, 514447, 514363, 514407, 514444, 514472, 514423, 514415, 514370, 514422, 549 69, 548140, 549 59, 5483657, 548468, 548196, 548527, 549480, 548532, 546119

Abstract:

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

US Patent:

61877999, Feb 13, 2001

Filed:

May 22, 1998

Appl. No.:

9/083399

Inventors:

Jill E Wood - Hamden CT
Hanno Wild - Wuppertal, DE
Daniel H Rogers - San Diego CA
John Lyons - Moraga CA
Michael Katz - Wallingford CT
Yolanda Caringal - Branford CT
Robert Dally - East Haven CT
Wendy Lee - Hamden CT
Roger A. Smith - Madison CT
Cheri Blum - Alameda CA

Assignee:

Onyx Pharmaceuticals - Richmond CA
Bayer Corporation - West Haven CT

International Classification:

A61K 3138
C07D40900
C07D33342
C07D30702

US Classification:

514363

Abstract:

Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

US Patent:

D339145, Oct 10, 1989

Filed:

Aug 17, 1987

Appl. No.:

7/086040

Inventors:

Milton Hinden - Glen Head NY
John Lyons - Levittown NY

Assignee:

Duro-Dyne Corporation - Farmingdale NY

US Classification:

D 8 141

US Patent:

43818986, May 3, 1983

Filed:

Jan 21, 1981

Appl. No.:

6/226756

Inventors:

Anthony J. Rotolico - Hauppauge NY
Eduardo Romero - Coram NY
John E. Lyons - Levittown NY

Assignee:

Eutectic Corporation - Flushing NY

International Classification:

B65G 5340

US Classification:

406118

Abstract:

The invention contemplates a powder-feeding system for gas-propelled delivery of a powder to be controllably supplied, as to a flame-spraying gas torch or to a transferred-arc plasma torch. A fluidizing chamber receives (a) fluidizing-gas flow from below a porous screen, and (b) a restricted gravitational flow of powder at a relatively small central discharge location above the porous screen. A gas conduit extends transversely through the chamber between the powder-discharge location and the porous screen; it has a carrier-gas supply connection at one end and a gas-propelled powder-delivery connection at its other end. The conduit also has an upwardly extending opening virtually beneath and facing the powder-discharge location, but a shed interposed between this opening and the powder-discharge location sufficiently overlaps the opening to assure that no powder will pass through the opening and into the conduit unless it has been gas-fluidized. The powder-discharge flow is blocked to gas flow when powder is being delivered by the carrier-gas flow, but the powder delivery is terminated promptly upon gas-venting the fluidizing chamber, via the powder-discharge flow or otherwise.

US Patent:

43918603, Jul 5, 1983

Filed:

Feb 23, 1981

Appl. No.:

6/237092

Inventors:

Anthony J. Rotolico - Hauppauge NY
Eduardo Romero - Coram NY
John E. Lyons - Levittown NY

Assignee:

Eutectic Corporation - Flushing NY

International Classification:

B05D 108
B05B 714
B05B 720

US Classification:

427423

Abstract:

The invention contemplates a powder-feeding system for gas-propelled delivery of a powder to be controllably supplied, as to a flame-spraying gas torch or to a transferred-arc plasma torch. A fluidizing chamber receives (a) fluidizing-gas flow from below a porous screen, and (b) a restricted gravitational flow of powder at a relatively small central discharge location above the porous screen. A gas conduit extends transversely through the chamber between the powder-discharge location and the porous screen; it has a carrier-gas supply connection at one end and a gas-propelled powder-delivery connection at its other end. The conduit also has an upwardly extending opening virtually beneath and facing the powder-discharge location, but a shed interposed between this opening and the powder-discharge location sufficiently overlaps the opening to assure that no powder will pass through the opening and into the conduit unless it has been gas-fluidized. The powder-discharge flow is blocked to gas flow when powder is being delivered by the carrier-gas flow, but the powder delivery is terminated promptly upon gas-venting the fluidizing chamber, via the powder-discharge flow or otherwise. A multiple-unit combination of such a system is also described wherein the proportion of different gas-fluidized powders may be selectively varied and/or coordinated to achieve various different application objectives, as in the course of a single run of a flame-spraying torch served by such combination.