John T Macdougall

US Patent:

20090181997, Jul 16, 2009

Filed:

Dec 23, 2008

Appl. No.:

12/343245

Inventors:

David GRAYZEL - Winchester MA, US
Robert Ross - Brookline MA, US
John MacDougall - Hingham MA, US

International Classification:

A61K 31/438

US Classification:

514278

Abstract:

The invention is directed to use of hedgehog inhibitors in conjunction with chemotherapy in treating cancers, and preventing relapses thereby.

US Patent:

20100297118, Nov 25, 2010

Filed:

Apr 16, 2010

Appl. No.:

12/762008

Inventors:

John MacDougall - Hingham MA, US
Kip A. West - Nahant MA, US

International Classification:

A61K 39/395
A61K 31/4355
A61K 31/517
A61K 31/5377
A61P 35/00

US Classification:

4241331, 514278, 5142664, 5142348, 4241551

Abstract:

Provided are methods for treating non-small cell lung cancer by administering a therapeutically effective amount of a hedgehog inhibitor.

US Patent:

20120010229, Jan 12, 2012

Filed:

Jul 8, 2011

Appl. No.:

13/179404

Inventors:

John R. MacDougall - Hingham MA, US
Karen J. McGovern - Groton MA, US

International Classification:

A61K 31/4355
A61P 35/00
C07D 491/04

US Classification:

514278, 546 15

Abstract:

Provided herein are methods, therapeutic regimens, and kits that optimize the benefits of hedgehog inhibition for cancer therapy.

US Patent:

20120010230, Jan 12, 2012

Filed:

Jul 8, 2011

Appl. No.:

13/179438

Inventors:

John R. MacDougall - Hingham MA, US
Juan Guillermo Paez - Spencer MA, US
Karen J. McGovern - Groton MA, US
Jeffery L. Kutok - Natick MA, US
Georgios Skliris - Cambridge MA, US
Kerry White - Medford MA, US
Kerrie L. Faia - Topsfield MA, US
Marisa Osswalt Peluso - Brookline MA, US
Veronica Travaglione Campbell - Framingham MA, US

International Classification:

A61K 31/4355
A61P 35/02
G01N 33/53
C12Q 1/02
C12Q 1/68
C12Q 1/37
C12Q 1/48
A61P 35/00
C40B 30/04

US Classification:

514278, 435 71, 506 9, 435 612, 435 23, 435 15, 435 29

Abstract:

Provided herein are methods, assays and kits for evaluating a sample, e.g., a sample obtained from a cancer patient, to detect one or more hedgehog biomarkers and/or one or more cilium markers. Thus, the invention can be used, inter alia, as a means to identify patients likely to benefit from administration of one or more hedgehog inhibitors, alone or in combination with therapeutic agents; to predict a time course of disease or a probability of a significant event in the disease of a cancer patient; to stratify patient populations; and/or to more effectively treat or prevent a cancer or a tumor associated with hedgehog signaling.

US Patent:

20220387619, Dec 8, 2022

Filed:

Aug 5, 2021

Appl. No.:

17/395369

Inventors:

Elisabet de los Pinos - Brookline MA, US
John Todd Schiller - Kensington MD, US
Rhonda C. Kines - Washington DC, US
John MacDougall - Hingham MA, US

Assignee:

Aura Biosciences, Inc. - Cambridge MA
The United States of America, as represented by the Secretary, Department of Health and Human Serv. - Bethesda MD

International Classification:

A61K 47/69
A61K 41/00
A61K 39/12
A61K 47/64
C07K 1/13
C07K 14/025
C07K 16/08
C07K 16/32
A61N 5/06
C12N 7/00

Abstract:

The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.