John R Macdougall

US Patent:

6964849, Nov 15, 2005

Filed:

Mar 15, 2002

Appl. No.:

10/099322

Inventors:

Luca Rastelli - Guilford CT, US
John L. Herrmann - Guilford CT, US
John R. MacDougall - Guilford CT, US
Haihong Zhong - Guilford CT, US

Assignee:

Curagen Corporation - New Haven CT

International Classification:

C12Q001/68
C12N015/63
A61K031/711
C07H021/04

US Classification:

435 6, 4352523, 43525411, 4353201, 435325, 514 44, 536 235

Abstract:

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

US Patent:

6991901, Jan 31, 2006

Filed:

Jan 11, 2002

Appl. No.:

10/044564

Inventors:

Luca Rastelli - Guilford CT, US
John L. Herrmann - Guilford CT, US
John R. MacDougall - Hamden CT, US
Haihong Zhong - Guilford CT, US

Assignee:

Curagen Corporation - New Haven CT

International Classification:

C12Q 1/68
C12N 15/63
A61K 31/711
C07H 21/04

US Classification:

435 6, 4352523, 43525411, 4353201, 435325, 514 44, 536 235

Abstract:

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

US Patent:

7141549, Nov 28, 2006

Filed:

Feb 8, 2005

Appl. No.:

11/054281

Inventors:

Peter Mezes - Old Lyme CT, US
Luca Rastelli - Guilford CT, US
John Herrmann - Guilford CT, US
John MacDougall - Hamden CT, US
Haihong Zhong - Guilford CT, US
Stacie Casman - North Haven CT, US
Ferenc Boldog - North Haven CT, US
Richard Shimkets - Guilford CT, US
Linda Gorman - Branford CT, US
Andrew Eisen - Rockville MD, US
Steven Spaderna - Berlin CT, US
Corine Vernet - Branford CT, US
Constance Berghs - New Haven CT, US
Kimberly Spytek - New Haven CT, US
Vincent DiPippo - East Haven CT, US
Bryan Zerhusen - Branford CT, US
John Peyman - New Haven CT, US
Karen Ellerman - Branford CT, US
David Stone - Guilford CT, US
William Grosse - Branford CT, US
John Alsobrook, II - Madison CT, US
Denise Lepley - Branford CT, US
Daniel Rieger - Branford CT, US
Catherine Burgess - Wethersfield CT, US
Shlomit Edinger - New Haven CT, US
Edward Voss - Wallingford CT, US
Charles Miller - Guilford CT, US

International Classification:

A61K 38/17
C07K 14/47

US Classification:

514 12, 530350

Abstract:

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

US Patent:

20020146807, Oct 10, 2002

Filed:

Jan 29, 2001

Appl. No.:

09/771730

Inventors:

Li Li - Cheshire CT, US
Sudhirdas Prayaga - O'Fallon MO, US
Muralidhara Padigaru - Branford CT, US
John MacDougall - Hamden CT, US
Kimberly Spytek - New Haven CT, US
Velizar Tchernev - Branford CT, US
Corine Vernet - North Branford CT, US

Assignee:

CuraGen Corporation

International Classification:

G01N033/53
G01N033/567
C12N001/12
C12N001/20
C07K001/00
C07K014/00
C07K017/00

US Classification:

435/252100, 530/350000, 435/007200

Abstract:

The present invention provides novel isolated NOVX polynucleotides and polypeptides encoded by the NOVX polynucleotides. Also provided are the antibodies that immunospecifically bind to a NOVX polypeptide or any derivative, variant, mutant or fragment of the NOVX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the NOVX polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

US Patent:

20030068618, Apr 10, 2003

Filed:

Jul 25, 2001

Appl. No.:

09/915043

Inventors:

Stacie Casman - North Haven CT, US
Catherine Burgess - Wethersfield CT, US
Valerie Gerlach - Branford CT, US
John MacDougall - Hamden CT, US
Glennda Smithson - Guilford CT, US

International Classification:

C12Q001/68
G01N033/574
C07H021/04
A61K048/00
C12P021/02
C12N005/06

US Classification:

435/006000, 435/007230, 435/069100, 435/183000, 435/320100, 435/325000, 514/044000, 536/023200

Abstract:

Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

US Patent:

20030232331, Dec 18, 2003

Filed:

Dec 4, 2001

Appl. No.:

10/005041

Inventors:

Stacie Casman - North Haven CT, US
Muralidhara Padigaru - Branford CT, US
Catherine Burgess - Wethersfield CT, US
Richard Shimkets - West Haven CT, US
Kimberly Spytek - New Haven CT, US
Jennifer Gilbert - Madison CT, US
Jane Mayotte - Middlefield CT, US
Jason Baumgartner - New Haven CT, US
Vishnu Mishra - Gainesville FL, US
Corine Vernet - Branford CT, US
Kevin Dickinson - Meriden CT, US
Robert Ballinger - Newington CT, US
Adam Wolenc - New Haven CT, US
Shlomit Edinger - New Haven CT, US
John MacDougall - Hamden CT, US
Glennda Smithson - Guilford CT, US
Karen Ellerman - Branford CT, US
David Stone - Guilford CT, US
Erik Gunther - Branford CT, US
Valerie Gerlach - Branford CT, US

International Classification:

C12Q001/68
G01N033/574
C07H021/04
C12P021/02
C12N005/06
C07K014/47
A61K048/00
C12N015/00

US Classification:

435/006000, 435/007230, 435/069100, 435/183000, 435/320100, 435/325000, 530/350000, 536/023200, 514/012000, 514/044000

Abstract:

Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

US Patent:

20040014173, Jan 22, 2004

Filed:

Mar 10, 2003

Appl. No.:

10/384974

Inventors:

David Anderson - Plantsville CT, US
Ferenc Boldog - North Haven CT, US
Stacie Casman - North Haven CT, US
Shlomit Edinger - New Haven CT, US
Karen Ellerman - Branford CT, US
Elma Fernandes - Branford CT, US
Erik Gunther - Branford CT, US
Martin Leach - Madison CT, US
John MacDougall - Hamden CT, US
Muralidhara Padigaru - Branford CT, US
Richard Shimkets - Guilford CT, US
Glennda Smithson - Guilford CT, US
Kimberly Spytek - Ellington CT, US

International Classification:

C12Q001/68
A61K038/17
C07H021/04
C12P021/02
C12N005/06
C07K014/705
C07K016/28

US Classification:

435/069100, 435/006000, 435/320100, 435/325000, 530/350000, 530/388220, 514/012000, 536/023500

Abstract:

The present invention provides novel polypeptides, termed SECX polypeptides, as well as polynucleotides encoding SECX polypeptides and antibodies that immunospecifically bind to SECX or a derivative, variant, mutant, or fragment of the SECX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the SECX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to others uses.

US Patent:

20040058338, Mar 25, 2004

Filed:

Dec 2, 2002

Appl. No.:

10/307817

Inventors:

Michele Agee - Wallingford CT, US
John Alsobrook - Madison CT, US
David Anderson - Branford CT, US
Constance Berghs - New Haven CT, US
Ferenc Boldog - North Haven CT, US
Catherine Burgess - Wethersfield CT, US
Elina Catterton - Madison CT, US
Vincent DiPippo - East Haven CT, US
Shlomit Edinger - New Haven CT, US
Andrew Eisen - Rockville MD, US
Karen Ellerman - Branford CT, US
Esha Gangolli - Acton MA, US
Valerie Gerlach - Branford CT, US
Linda Gorman - Branford CT, US
Bonnie Rothberg - Guilford CT, US
Xiaojia Guo - Branford CT, US
John Herrmann - Guilford CT, US
Weizhen Ji - Branford CT, US
Ramesh Kekuda - Norwalk CT, US
Nikolai Khramtsov - Branford CT, US
William LaRochelle - Madison CT, US
Denise Lepley - Branford CT, US
Li Li - Branford CT, US
John MacDougall - Hamden CT, US
Charles Miller - Guilford CT, US
Tatiana Ort - Milford CT, US
Muralidhara Padigaru - Branford CT, US
Meera Patturajan - Branford CT, US
Carol Pena - Guilford CT, US
John Peyman - New Haven CT, US
Daniel Rieger - Branford CT, US
Mark Rothenberg - Clinton CT, US
Suresh Shenoy - Branford CT, US
Glennda Smithson - Guilford CT, US
Steven Spaderna - Berlin CT, US
Kimberly Spytek - New Haven CT, US
David Stone - Guilford CT, US
Raymond Taupier - East Haven CT, US
Corine Vernet - Branford CT, US
Edward Voss - Wallingford CT, US
Mei Zhong - Branford CT, US

International Classification:

C12Q001/68
G01N033/53
A61K048/00
A61K038/17
C07H021/04
C12N009/00
C07K014/47

US Classification:

435/006000, 435/069100, 435/183000, 435/320100, 435/325000, 514/012000, 530/350000, 536/023200, 435/007100

Abstract:

The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.