John M Maloney

US Patent:

7497855, Mar 3, 2009

Filed:

Sep 4, 2003

Appl. No.:

10/654761

Inventors:

Dennis Ausiello - Wellesley Hill MA, US
Stephen J. Herman - Andover MA, US
James H. Prescott - Cambridge MA, US
Scott A. Uhland - Roslindale MA, US
John M. Maloney - Cambridge MA, US
Benjamin F. Polito - Lebanon NH, US

Assignee:

MicroCHIPS, Inc. - Bedford MA

International Classification:

A61K 9/22

US Classification:

6048901

Abstract:

Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e. g. , two months, ten months, or more. ). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

US Patent:

7925274, Apr 12, 2011

Filed:

Jun 17, 2008

Appl. No.:

12/141029

Inventors:

Robert J. Anderson - Phoenixville PA, US
John E. Maloney - Springfield VA, US
Matthew L. Ward - Collegeville PA, US

Assignee:

TruePosition, Inc. - Berwyn PA

International Classification:

H04W 24/00

US Classification:

4554561, 4554321, 455433, 455436, 4554562, 4554563

Abstract:

A method and system for enhancing the accuracy and robustness of locations determined for a mobile wireless transceiver in a cellular telephone communications system integrating location-related information both from an assisted GPS device embedded in the mobile unit and from infrastructure-based facilities that extract signal characteristic data at networked base stations. Available supporting collateral information may be additionally evaluated in the location determinations to provide location estimates of enhanced robustness and accuracy.

US Patent:

8277440, Oct 2, 2012

Filed:

Jan 23, 2009

Appl. No.:

12/358850

Inventors:

Dennis Ausiello - Wellesley Hill MA, US
Stephen J. Herman - Andover MA, US
James H. Prescott - Cambridge MA, US
Scott A. Uhland - Medford MA, US
John M. Maloney - Cambridge MA, US
Benjamin F. Polito - Lebanon NH, US

Assignee:

MicroCHIPS, Inc. - Waltham MA

International Classification:

A61K 9/22

US Classification:

6048911

Abstract:

Method and devices are provided for extended and controlled delivery of parathyroid hormone to a patient. The method includes implanting a medical device into the patient, the medical device comprising a substrate, a plurality of reservoirs in the substrate, a release system contained in each of the reservoirs, wherein the release system comprises parathyroid hormone; and controllably releasing a pharmaceutically effective amount of the parathyroid hormone from the reservoirs. The parathyroid hormone can be released intermittently, such as once daily over an extended period (e. g. , two months, ten months, or more. ). The device can further include reservoirs containing a bone resorption inhibitor or other drug for release. The devices are useful in delivering PTH for the treatment and prevention of bone loss, such as associated with osteoporosis.

US Patent:

20050055014, Mar 10, 2005

Filed:

Aug 4, 2004

Appl. No.:

10/911175

Inventors:

Jonathan Coppeta - Windham NH, US
John Maloney - Cambridge MA, US
Benjamin Polito - Flagstaff AZ, US
John Santini - North Chelmsford MA, US
Norman Sheppard - Bedford MA, US
Scott Uhland - Roslindale MA, US

International Classification:

A61K009/22

US Classification:

604890100

Abstract:

Methods and devices are provided for selective release or exposure of reservoir contents, such as a drug formulation or diagnostic reagent, sealed in a reservoir, e.g., a microreservoir. The devices comprise a substrate; one or more reservoirs located in and defined by the substrate; reservoir contents located inside the reservoirs; a reservoir cap or rupturable layer sealing an outlet of the reservoir; and means for disintegrating the reservoir cap or rupturing the rupturable layer; and means for accelerating the release of the reservoir contents from the reservoir through the outlet, or for enhancing diffusional mass transport of a material into or out of the reservoir. The means for accelerating can, for example, include a shape memory material. In a preferred embodiment, the device is adapted for implantation into a human or animal body and comprises an array of several discrete reservoir, each one being individually openable at a desired time.

US Patent:

42136440, Jul 22, 1980

Filed:

Aug 17, 1978

Appl. No.:

5/934359

Inventors:

Jerry V. Scrivo - Durham NH
John V. Maloney - Dover NH

Assignee:

McCord Corporation - Detroit MI

International Classification:

B60R 1908

US Classification:

293117

Abstract:

An automotive body assembly including an energy absorbing bumper assembly of elastomeric foam material, such as urethane, for compressing to absorb energy in response to an impact with a light means disposed in a recess and support means connected to the light means and supported by the elastomeric material for moving with the elastomeric material upon the compression thereof to move the light means and thereafter return the light means to the initial position. The support means includes an eyebrow portion disposed forwardly of the light means. In one embodiment the eyebrow portion is embedded within the elastomeric material and in another embodiment the eyebrow portion is disposed over the elastomeric material.