John L Mccullough

US Patent:

50812254, Jan 14, 1992

Filed:

Jul 31, 1989

Appl. No.:

7/388089

Inventors:

Joseph O'Sullivan - Belle Mead NJ
John E. McCullough - Whitehouse Station NJ
Janice H. Del Mar - Hopewell NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07K 754

US Classification:

530317

Abstract:

A novel antibiotic substance, janthinocin, is prepared by cultivation of a strain of the microorganism Janthinobacterium lividum, ATCC No. 53,857.

US Patent:

52228827, Jun 29, 1993

Filed:

Feb 20, 1992

Appl. No.:

7/837966

Inventors:

John E. McCullough - Carlisle MA

Assignee:

Arthur D. Little, Inc. - Cambridge MA

International Classification:

F01C 104
F01C 1908

US Classification:

418 552

Abstract:

A tip seal supporting structure for use in a scroll fluid device includes intermeshing involute scroll elements mounted for relative orbital movement. Each of the scroll elements includes an involute spiral wrap which is secured to a respective wrap support plate at one axial end thereof. Each involute spiral wrap is provided with a tip seal in the other axial end thereof which engages with the wrap support plate of the other scroll element. One of the wrap support plates includes a substantially, centrally located fluid passage into which the innermost end of the involute spiral wrap of the other scroll element extends during a predetermined portion of the relative orbital movement between the scroll elements. In one embodiment of the invention, a tip seal supporting structure in the form of a bridge extends across a predetermined portion of this central fluid passage and functions to axially support the innermost portion of the tip seal that extends into this fluid passage during relative orbital movement of the scroll wraps to thereby prevent destructive vibrational effects, to permit the tip seals to extend into the center of the involute scrolls as much as possible, and to maximize the efficiency of the scroll fluid device. In other embodiments, the tip seal is attached to the involute spiral wrap by a fastener.

US Patent:

61302422, Oct 10, 2000

Filed:

Dec 29, 1998

Appl. No.:

9/222132

Inventors:

Vincent L. Fabiano - Princeton NJ
John R. McCullough - Hudson MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3300

US Classification:

514428

Abstract:

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-procyclidine. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-procyclidine enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

US Patent:

45120668, Apr 23, 1985

Filed:

Mar 2, 1981

Appl. No.:

6/239414

Inventors:

John E. McCullough - Carlisle MA

Assignee:

Arthur D. Little, Inc. - Cambridge MA

International Classification:

B23D 1502

US Classification:

29 235

Abstract:

Method for forming scroll members comprising an end plate having an involute wrap rigidly affixed thereto. The end plate and involute wrap are precision formed, e. g. , by casting, either as an integral element or as two separate elements and then the scroll member is broached to the desired dimensional accuracy and finish. Push broaching is accomplished with an involute broaching tool which has a single terminating cutting edge on one or both sides of an involute blade cutter.

US Patent:

52861791, Feb 15, 1994

Filed:

Feb 20, 1992

Appl. No.:

7/837965

Inventors:

Ronald J. Forni - Lexington MA
Robert M. Lucas - Lynnfield MA
John E. McCullough - Carlisle MA
Richard J. Whitehead - Chelmsford MA
Shigeki Hagiwara - Sakai, JP
Hiromichi Ueno - all os Sakai, JP
Katsumi Sakitani - all os Sakai, JP
Yoshitaka Shibamoto - all os Sakai, JP
Hiroyuki Taniwa - all os Sakai, JP

Assignee:

Arthur D. Little, Inc. - Cambridge MA

International Classification:

F01C 104
F01C 2104
F01C 2106

US Classification:

418 551

Abstract:

A thermal isolation arrangement for use in a co-rotating scroll refrigerant compressor includes various thermal insulation elements adapted to minimize heat transfer between hot rotating members of the scroll fluid device and the return refrigerant to be compressed, and between hot lubricant in the compressor and the return refrigerant. The thermal isolation elements of the present invention may be used individually or collectively to minimize the preheating of the inlet refrigerant so as to maintain the density of the return refrigerant being compressed to thereby increase the total efficiency of the scroll fluid device.

US Patent:

45542503, Nov 19, 1985

Filed:

Jun 30, 1983

Appl. No.:

6/509501

Inventors:

John E. McCullough - Whitehouse Station NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C12N 1500
C12N 120
C12N 986
C12N 100

US Classification:

4351723

Abstract:

A method is provided for enhancing penicillin acylase production wherein a Bacillus subtilis plasmid containing an insert of a chromosomal DNA fragment of Bacillus megaterium which includes the appropriate gene for enhancing penicillin acylase production is cloned into Bacillus megaterium and the Bacillus megaterium containing the above plasmid is employed in the production of penicillin acylase. A plasmid method for forming same and host plasmid combination which are useful in the above method are also provided.

US Patent:

60638087, May 16, 2000

Filed:

Dec 29, 1998

Appl. No.:

9/214169

Inventors:

Vincent L. Fabiano - Princeton NJ
John R. McCullough - Hudson MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3140

US Classification:

514424

Abstract:

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S,S)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S,S)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, substantially free of the (R,R)-glycopyrrolate enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S,S)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

US Patent:

56208928, Apr 15, 1997

Filed:

Sep 7, 1993

Appl. No.:

8/118101

Inventors:

Stephen E. Kurtz - Princeton NJ
Aron M. Knickerbocker - Titusville NJ
John R. McCullough - Newtown PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 118
C12N 119

US Classification:

43535421

Abstract:

A modified Saccharomyces cerevisiae cell, wherein the cell expresses minK but does not express TRK1 and TRK2. Also disclosed is a process for detecting modulators of minK, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test compound, (b) assessing growth in the presence of a test compound and (c) determining an increase or decrease in potassium uptake into the Saccharomyces cerevisiae cells. MinK inhibitors are useful anti-arrhythmic or antifibrillatory agents; activators, anti-ischemic agents.