John W Mccullough

US Patent:

50812254, Jan 14, 1992

Filed:

Jul 31, 1989

Appl. No.:

7/388089

Inventors:

Joseph O'Sullivan - Belle Mead NJ
John E. McCullough - Whitehouse Station NJ
Janice H. Del Mar - Hopewell NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07K 754

US Classification:

530317

Abstract:

A novel antibiotic substance, janthinocin, is prepared by cultivation of a strain of the microorganism Janthinobacterium lividum, ATCC No. 53,857.

US Patent:

61302422, Oct 10, 2000

Filed:

Dec 29, 1998

Appl. No.:

9/222132

Inventors:

Vincent L. Fabiano - Princeton NJ
John R. McCullough - Hudson MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3300

US Classification:

514428

Abstract:

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-procyclidine. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-procyclidine enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S)-procyclidine, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

US Patent:

45542503, Nov 19, 1985

Filed:

Jun 30, 1983

Appl. No.:

6/509501

Inventors:

John E. McCullough - Whitehouse Station NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C12N 1500
C12N 120
C12N 986
C12N 100

US Classification:

4351723

Abstract:

A method is provided for enhancing penicillin acylase production wherein a Bacillus subtilis plasmid containing an insert of a chromosomal DNA fragment of Bacillus megaterium which includes the appropriate gene for enhancing penicillin acylase production is cloned into Bacillus megaterium and the Bacillus megaterium containing the above plasmid is employed in the production of penicillin acylase. A plasmid method for forming same and host plasmid combination which are useful in the above method are also provided.

US Patent:

60638087, May 16, 2000

Filed:

Dec 29, 1998

Appl. No.:

9/214169

Inventors:

Vincent L. Fabiano - Princeton NJ
John R. McCullough - Hudson MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3140

US Classification:

514424

Abstract:

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S,S)-glycopyrrolate. The method comprises administering a therapeutically effective amount of enantiomerically enriched (S,S)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, substantially free of the (R,R)-glycopyrrolate enantiomer. Pharmaceutical compositions for the treatment of urinary incontinence comprising enantiomerically enriched (S,S)-glycopyrrolate, or a pharmaceutically acceptable salt thereof, and an acceptable carrier are also disclosed.

US Patent:

56208928, Apr 15, 1997

Filed:

Sep 7, 1993

Appl. No.:

8/118101

Inventors:

Stephen E. Kurtz - Princeton NJ
Aron M. Knickerbocker - Titusville NJ
John R. McCullough - Newtown PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C12N 118
C12N 119

US Classification:

43535421

Abstract:

A modified Saccharomyces cerevisiae cell, wherein the cell expresses minK but does not express TRK1 and TRK2. Also disclosed is a process for detecting modulators of minK, which comprises (a) treating such modified Saccharomyces cerevisiae cells with a test compound, (b) assessing growth in the presence of a test compound and (c) determining an increase or decrease in potassium uptake into the Saccharomyces cerevisiae cells. MinK inhibitors are useful anti-arrhythmic or antifibrillatory agents; activators, anti-ischemic agents.

US Patent:

60637927, May 16, 2000

Filed:

Dec 29, 1998

Appl. No.:

9/214170

Inventors:

Vincent L. Fabiano - Princeton NJ
John R. McCullough - Hudson MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A01N 4340

US Classification:

514315

Abstract:

Disclosed are methods for treating urinary incontinence using enantiomerically enriched (S)-trihexyphenidyl.

US Patent:

6110972, Aug 29, 2000

Filed:

Dec 29, 1998

Appl. No.:

9/214166

Inventors:

Vincent L. Fabiano - Princeton NJ
John R. McCullough - Hudson MA

Assignee:

Sepracor Inc. - Marlborough MA

International Classification:

A61K 3114

US Classification:

514643

Abstract:

A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (S)-tridihbexethyl (I), is disclosed. The method comprises administering a therapeutically effective amount of enantiomerically enriched I, or a pharmaceutically acceptable salt thereof, substantially free of the (R)-tridihexethyl enantiomer.

US Patent:

47540184, Jun 28, 1988

Filed:

Mar 9, 1987

Appl. No.:

7/023425

Inventors:

Adrienne A. Tymiak - Hopewell NJ
Donald R. Kirsch - Princeton NJ
Joseph O'Sullivan - Belle Mead NJ
John E. McCullough - Whitehouse Station NJ

Assignee:

E. R. Squibb & Sons, Inc. - Princeton NJ

International Classification:

C07K 512

US Classification:

530317

Abstract:

A novel antibiotic substance EM5587 is prepared by cultivation of a strain of the microorganism Lysobacter sp. SC 14,067, A. T. C. C. No. 53042. Chemical analogs of EM5587 are prepared by chemical synthesis.