John M Mclane

US Patent:

53428331, Aug 30, 1994

Filed:

Nov 22, 1993

Appl. No.:

8/155663

Inventors:

Thomas I. Doran - West Orange NJ
John A. McLane - New Haven CT
Masami Okabe - Nutley NJ
Michelangelo Scalone - Birsfelden, CH
Milan R. Uskokovic - Upper Montclair, NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40100

US Classification:

514167

Abstract:

The invention is drawn to compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.

US Patent:

50735683, Dec 17, 1991

Filed:

Nov 14, 1988

Appl. No.:

7/270980

Inventors:

Peter M. Wovkulich - Nutley NJ
Milan R. Uskokovic - Upper Montclair NJ
Ann Goldstein - Upper Montclair NJ
John A. McLane - West Haven CT

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

A61K 31365
C07D30910

US Classification:

514460

Abstract:

The invention relates to compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or methyl; A is ##STR2## or A is ##STR3## wherein R. sub. 2 is lower alkyl; R. sub. 3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R. sub. 4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR4## wherein A is ##STR5## or A is ##STR6## and R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are as described above; or a pharmaceutically acceptable salt of said acid, a C. sub. 1-4 alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha. -monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.

US Patent:

52005496, Apr 6, 1993

Filed:

Sep 24, 1991

Appl. No.:

7/764641

Inventors:

Peter M. Wovkulich - Nutley NJ
Milan R. Uskokovic - Upper Montclair NJ
Ann Goldstein - Upper Montclair NJ
John A. McLane - West Haven CT

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

C07C 6976
C07C 6963

US Classification:

560 61

Abstract:

The invention relates to compounds of the formula ##STR1## wherein R. sub. 1 is hydrogen or methyl; ##STR2## wherein R. sub. 2 is lower alkyl; R. sub. 3 is phenyl, or phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; and R. sub. 4 is hydrogen or methyl or the corresponding hydroxy acid of formula ##STR3## and R. sub. 1, R. sub. 2, R. sub. 3 and R. sub. 4 are as described above; or a pharmaceutically acceptable salt of said acid, a C. sub. 1-4 alkyl ester of said acid, an acetylamino-substituted-C. sub. 1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a. alpha. -monoglyceride of said acid. The compounds of formulas I and II are useful as agents for the treatment of hyperproliferative skin diseases such as psoriasis.

US Patent:

53939000, Feb 28, 1995

Filed:

Jun 7, 1994

Appl. No.:

8/255012

Inventors:

Thomas I. Doran - West Orange NJ
John A. McLane - New Haven CT
Masami Okabe - Nutley NJ
Michelangelo Scalone - Birsfelden, CH
Milan R. Uskokovic - Upper Montclair NJ

Assignee:

Hoffmann-La Roche inc. - Nutley NJ

International Classification:

C07J 900

US Classification:

552505

Abstract:

The invention comprises compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen, useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases. The invention also includes a process for making these compounds and steroid intermediates of the process.

US Patent:

54280290, Jun 27, 1995

Filed:

Nov 24, 1993

Appl. No.:

8/158068

Inventors:

Thomas I. Doran - West Orange NJ
Bernard M. Hennessy - Nutley NJ
John A. McLane - West Haven CT
Giacomo Pizzolato - Glen Ridge NJ
Farhad Sedarati - Wayne NJ
Milan R. Uskokovic - Upper Montclair NJ

Assignee:

Hoffmann-La Roche Inc. - Nutley NJ

International Classification:

C07C40100

US Classification:

514167

Abstract:

Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, X is H. sub. 2 or. dbd. CH. sub. 2, and the 23,24-double bond is E or Z, are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of tumors such as breast cancer, as agents for the treatment of neoplastic diseases such as leukemia, and as agents for the treatment of sebaceous gland diseases such as acne and seborrheic dermatitis.

US Patent:

57474788, May 5, 1998

Filed:

Nov 23, 1994

Appl. No.:

8/344421

Inventors:

Thomas I. Doran - West Orange NJ
John Arthur McLane - New Haven CT

Assignee:

Hoffman-La Roche Inc. - Nutley NJ

International Classification:

A61K 3159

US Classification:

514167

Abstract:

Compounds of the formula ##STR1## wherein R. sup. 1 and R. sup. 2 are hydrogen or acyl; provided that only one of R. sup. 1 or R. sup. 2 is hydrogen are taught as useful in the treatment of hyperproliferative skin diseases and sebaceous gland diseases.