John K Neubert

US Patent:

20100331722, Dec 30, 2010

Filed:

Aug 10, 2005

Appl. No.:

11/201452

Inventors:

Robert Martin Caudle - Gainesville FL, US
John Kim Neubert - Gainesville FL, US

International Classification:

A61D 99/00
A01K 1/03
A01K 29/00

US Classification:

600555, 119421, 119712, 600557

Abstract:

The subject invention concerns a method and device for assessing facial pain sensitivity exhibited by an animal. The device and method can be used, for example, to evaluate the effect of a disease state, drug, or other intervention, on facial pain sensitivity, such as orofacial pain sensitivity. In one embodiment, the device and method provide a way of assessing both heat and cold sensitivity (hyperalgesia and allodynia) in the facial region in a non-invasive manner. Additionally, since the animals can be kept unrestrained, there are less confounding factors such as stress, which are inherent to other facial pain testing techniques.

US Patent:

20180297966, Oct 18, 2018

Filed:

Oct 17, 2016

Appl. No.:

15/768996

Inventors:

- Gainesville FL, US
Alexander A. Oliferenko - Gainesville FL, US
John K. Neubert - Gainesville FL, US
Gary I. Altschuler - Gainesville FL, US
Robert A. Hromas - Gainesville FL, US
David Ostrov - Gainesville FL, US
William L. Castleman - Gainesville FL, US

International Classification:

C07D 291/06
A61K 31/137
A61K 9/00
A61P 29/00
C07C 215/60
C07C 213/08
C07C 237/04
C07C 231/12
C07C 65/21
C07C 51/41
C07H 15/24
C07D 275/06
C07C 229/64
C07C 227/16
A61K 31/4458
A61K 31/445
A61K 31/167
A61K 31/381

Abstract:

Compounds are provided according to Formula (I), and hydrates thereof, and compositions thereof; and methods of using and making the same. Compounds of the present invention are contemplated useful for suppressing pain during cosmetic, medical, and dental procedures. In another aspect, provided herein is a composition comprising the compound of Formula (I) or hydrate thereof and a pharmaceutically acceptable carrier.