John R Nicholas

US Patent:

7198590, Apr 3, 2007

Filed:

Sep 28, 2005

Appl. No.:

11/236955

Inventors:

John Nicholas - Simi Valley CA, US

International Classification:

A63B 69/18

US Classification:

482 71, 482 51, 434253

Abstract:

A ski training apparatus is provided that simulate movement similar to alpine skiing. A pivoting arm is mounted at the base of the front vertical post and carries a parallelogram linkage assembly, with two flanged wheels mounted on the linkage assembly. A guide swivel is mounted on the floor base underneath the flanged wheels. Two horizontal and parallel foot platforms are mounted on the linkage assembly for rocking motion about vertical parallel axes. The pivoting arm, foot platforms, flanged wheels and guiding swivel constitute a low friction mechanism that provides the compound motion similar to that of alpine skiing. A holding bar and a padded lower back rest will maintain the body properly positioned.

US Patent:

20110081315, Apr 7, 2011

Filed:

Sep 24, 2010

Appl. No.:

12/890475

Inventors:

Brad Buckman - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Leonid Beigelman - San Mateo CA, US
Vladimir Serebryany - Burlingame CA, US
Antitsa Dimitrova Stoycheva - Half Moon Bay CA, US
Timothy Thrailkill - San Francisco CA, US
Scott Seiwert - Pacifica CA, US

Assignee:

INTERMUNE, INC. - Brisbane CA

International Classification:

A61K 38/21
C07D 487/04
A61K 31/437
A61K 31/427
A61K 31/428
A61K 31/5377
A61K 31/445
A61K 31/506
A61K 31/4192
A61K 31/422
A61K 31/4725
A61K 31/522
A61K 31/498
C12N 9/99
C12N 5/02

US Classification:

424 855, 540460, 514303, 514369, 514367, 51421021, 5142332, 514322, 514256, 514359, 514374, 514309, 5142632, 514249, 435184, 424 857, 435375

Abstract:

The embodiments provide compounds of the general Formulae I, Ia, II, III, IV, V, VI-1, VI-2, VII, VIII, IX, X, XI, and XII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

US Patent:

20110129444, Jun 2, 2011

Filed:

Sep 24, 2010

Appl. No.:

12/890470

Inventors:

BRAD BUCKMAN - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Vladimir Serebryany - Burlingame CA, US
Scott Seiwert - Pacifica CA, US

Assignee:

INTERMUNE, INC - Brisbane CA

International Classification:

A61K 38/12
C07K 5/087
A61P 31/14
A61K 38/21
A61P 1/16
C12N 9/99

US Classification:

424 855, 530331, 514 211, 514 43, 424 857, 435184

Abstract:

The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

US Patent:

20110152246, Jun 23, 2011

Filed:

Dec 16, 2010

Appl. No.:

12/970492

Inventors:

Brad Buckman - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Vladimir Serebryany - Burlingame CA, US
Scott D. Seiwert - Pacifica CA, US

Assignee:

InterMune, Inc. - Brisbane CA

International Classification:

A61K 31/553
C07D 403/14
C07D 277/62
C07D 233/64
C07D 263/56
C07D 221/06
C07D 233/54
C07D 267/18
A61K 31/4184
A61K 31/428
A61K 31/4178
A61K 31/421
A61K 31/497
A61K 31/435
A61K 31/451
C07D 279/18
A61K 31/5415
A61P 31/14

US Classification:

51421104, 5483061, 548152, 5483114, 548217, 544370, 544295, 546101, 5483131, 5483117, 540488, 514394, 514367, 514397, 514375, 51425405, 5142522, 514290, 514326, 544 35, 5142278

Abstract:

The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

US Patent:

20110312996, Dec 22, 2011

Filed:

May 16, 2011

Appl. No.:

13/108211

Inventors:

Brad Buckman - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Vladimir Serebryany - Burlingame CA, US
Scott D. Seiwert - Pacifica CA, US

Assignee:

InterMune, Inc. - Brisbane CA

International Classification:

A61K 31/4709
C07D 401/12
C07D 233/28
C07D 403/12
C07D 403/14
C07D 417/14
C07D 409/14
C07D 413/14
C07D 405/14
C07D 401/14
C07D 487/04
C07D 471/04
A61K 31/4184
A61K 31/4178
A61K 31/428
A61K 31/423
A61P 31/14
A61P 1/16
C07D 403/04

US Classification:

514314, 5483147, 5462791, 5483341, 544372, 5483057, 548455, 548156, 5483114, 548219, 5483131, 548518, 546167, 544284, 544328, 544280, 5483121, 5483051, 546112, 540593, 548217, 548159, 544119, 544296, 514394, 514397, 514367, 514375

Abstract:

The embodiments provide compounds of the general Formulae VI, VII, VIII, IX, X, XI, XII, XIII, XIV, and XV as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

US Patent:

20120094897, Apr 19, 2012

Filed:

Sep 14, 2011

Appl. No.:

13/232815

Inventors:

Brad Buckman - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Vladimir Serebryany - Burlingame CA, US
Scott D. Seiwert - Pacifica CA, US

Assignee:

InterMune, Inc. - Brisbane CA

International Classification:

A61K 38/06
A61P 31/14
A61P 1/16
C07K 5/093
C07K 5/083
G21C 3/00

US Classification:

514 43, 530331

Abstract:

The embodiments provide compounds of the general Formulae I, and II, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

US Patent:

20120095211, Apr 19, 2012

Filed:

Sep 20, 2011

Appl. No.:

13/237843

Inventors:

Brad Buckman - Oakland CA, US
John B. Nicholas - Redwood City CA, US
Vladimir Serebryany - Burlingame CA, US
Scott D. Seiwert - Halfmoon Bay CA, US

Assignee:

InterMune, Inc. - Brisbane CA

International Classification:

C07D 487/04

US Classification:

540460

Abstract:

The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

US Patent:

20120101032, Apr 26, 2012

Filed:

Oct 21, 2011

Appl. No.:

13/278984

Inventors:

Brad BUCKMAN - Oakland CA, US
Vladimir SEREBRYANY - Burlingame CA, US
John B. NICHOLAS - Redwood City CA, US
Scott SEIWERT - Pacifica CA, US

Assignee:

INTERMUNE, INC. - Brisbane CA

International Classification:

A61K 38/06
A61P 1/16
A61P 31/14
C07K 5/083
C12N 9/99

US Classification:

514 43, 530331, 514 201, 435184

Abstract:

The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IV, IVa, V, Va, VI and VIa, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.