John M O'Neill

US Patent:

7655756, Feb 2, 2010

Filed:

May 26, 2006

Appl. No.:

11/442004

Inventors:

Marta C. Abad - Downingtown PA, US
Dionisios Rentzeperis - Downingtown PA, US
John O'Neill - Downingtown PA, US
Hossein B. Askari - Exton PA, US
Cynthia M. Milligan - Exton PA, US
Frank A. Lewandowski - Exton PA, US

Assignee:

Johnson & Johnson Pharmaceutical Research & Development, LLC - New Brunswick NJ

International Classification:

C07K 14/00
A61K 38/16
C08H 1/00

US Classification:

530350, 530358, 530402

Abstract:

A method for the identification of novel compounds that interact and stabilize the ligand binding domain of estrogen-related receptor gamma (ERRγ), a methodology for producing diffraction quality crystal structures in the presence of antagonist and agonist ligands, including Bisphenol A, and the identification of novel biologically-active compounds that have an effect on the transcriptional-activating activity of ERRγ are disclosed.

US Patent:

40876470, May 2, 1978

Filed:

May 25, 1977

Appl. No.:

5/800220

Inventors:

Milton Luther Embree - Reading PA
John Francis O'Neill - Boulder CO

Assignee:

Bell Telephone Laboratories, Incorporated - Murray Hill NJ

International Classification:

H04M 1908

US Classification:

179 77

Abstract:

A local battery feed circuit for telephone station sets comprises two half circuit portions substantially symmetric about an imaginary line midway between the TIP and RING telephone lines. Each half circuit includes a current drive amplifier including a pair of up-down emitter follower transistors and a driver transistor. A coupling capacitor and matched resistors provide common mode interference reduction without degrading differential mode signals. Power supply noise is substantially eliminated by transistors in each half circuit arranged to produce an a. c. current equal and opposite to that generated from the power source.

US Patent:

40469689, Sep 6, 1977

Filed:

Aug 5, 1976

Appl. No.:

5/711810

Inventors:

Milton Luther Embree - Reading PA
David Clayton Goldthorp - Reading PA
John Francis O'Neill - Boulder CO

Assignee:

Bell Telephone Laboratories, Incorporated - Murray Hill NJ

International Classification:

H04Q 128

US Classification:

179 18FA

Abstract:

A line transformer circuit in which the DC component of magnetization produced in the tip and ring windings by the battery supplying loop current to the telephone set microphone may be neutralized by an oppositely-poled, serially-connected balancing winding is disclosed. One end of the balancing winding is connected to the supply battery and is, therefore, at AC ground. The other end is kept at a point of high AC impedance to ground by the collector of a transistor so that audio frequency voltages induced in the balancing winding cannot load the transformer. The AC currents in the tip and ring windings are provided with a virtual ground return path by means of a differential amplifier controlled Darlington pair in circuit between the tip and ring windings and the balancing winding. The AC components of the Darlington pair collector current are bypassed to ground by a shunt capacitor at the junction of the Darlington pair collector terminal and the third winding. The differential amplifier senses voltage changes at the virtual ground so that the Darlington pair is driven to suppress these changes.