John S Ray

US Patent:

7402606, Jul 22, 2008

Filed:

Apr 1, 2003

Appl. No.:

10/510469

Inventors:

David Gene Barrett - Henstedt-Ulzburg, DE
John G. Catalano - Durham NC, US
David Norman Deaton - Durham NC, US
Aaron Bayne Miller - Durham NC, US
John A. Ray - Durham NC, US
Vicente Samano - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/341
A61K 31/4015
A61K 31/4025
A61K 31/404
A61K 31/4155
A61K 31/416
A61K 31/4192
A61K 31/4196
A61K 31/4245
A61K 31/42
A61K 31/433
A61K 31/4439
A61K 31/4709
A61K 31/497
A61K 31/5377

US Classification:

514424, 514423, 514414, 514406, 514378, 514367, 514365, 514361, 514364, 514363, 514314, 514343, 51425505, 5142355, 544141, 544405, 5462784, 546168, 5462704, 548544, 548556, 548525, 548127, 548236, 548255, 548261, 548468, 548248, 5482668, 5483625, 548247, 548203, 548131, 548162, 549475

Abstract:

Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such heterocycle substituted ketoamide derivatives as well as method of using the same in the manufacture of medicaments for the treatment of disorders, including osteoporosis, associated with an imbalance between bone resorption and formation which can ultimately lead to fracture.

US Patent:

7442833, Oct 28, 2008

Filed:

Oct 4, 2004

Appl. No.:

10/575038

Inventors:

Dennis Heyer - Durham NC, US
Amarjit Sab Randhawa - Durham NC, US
Vicente Samano - Durham NC, US
John Albert Ray - Durham NC, US
Subba Reddy Katamreddy - Durham NC, US
Michael Tolar Martin - Durham NC, US
Michael Scott McClure - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

C07C 63/33
A61K 31/19

US Classification:

562491, 514570

Abstract:

Compounds of formula (I):.

US Patent:

7572820, Aug 11, 2009

Filed:

Sep 27, 2007

Appl. No.:

11/862531

Inventors:

Philip Stewart Turnbull - Durham NC, US
Rodolfo Cadilla - Durham NC, US
Andrew Larkin - Durham NC, US
Eugene L. Stewart - Durham NC, US
Katherine Stetson - Durham NC, US
Darryl Lynn McDougald - Durham NC, US
Amarjit Sab Randhawa - Durham NC, US
John A. Ray - Durham NC, US

Assignee:

SmithKline Beecham Corporation - Philadelphia PA

International Classification:

A61K 31/427
C07D 271/06
C07D 413/06

US Classification:

514364, 548125, 548131, 514361

Abstract:

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

US Patent:

8026262, Sep 27, 2011

Filed:

Jul 1, 2009

Appl. No.:

12/496374

Inventors:

Philip Stewart Turnbull - Durham NC, US
Rodolfo Cadilla - Durham NC, US
Andrew Larkin - Durham NC, US
Eugene L. Stewart - Durham NC, US
Katherine Stetson - Durham NC, US
Darryl Lynn McDougald - Durham NC, US
Amarjit Sab Randhawa - Durham NC, US
John A. Ray - Durham NC, US

Assignee:

GlaxoSmithKline LLC - Philadelphia PA

International Classification:

A61K 31/4245
C07D 413/06

US Classification:

514361, 548125, 548131

Abstract:

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

US Patent:

20050107616, May 19, 2005

Filed:

Jul 23, 2002

Appl. No.:

10/485656

Inventors:

David Gene Barrett - Hauctecht-Ulzburg, DE
David Deaton - Durham NC, US
Robert Mcfadyen - Durham NC, US
Aaron Miller - Durham NC, US
John Ray - Durham NC, US
Francis Tavares - Durham NC, US
Huiqiang Zhou - Durham NC, US

International Classification:

C07D213/55
C07D207/46

US Classification:

546335000, 548571000, 558234000, 560033000

Abstract:

Biaryl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such biaryl ketoamide derivatives as well as methods of using the same in the treatment of disorders, including osteoporosis, associated with enhanced bone turnover which can ultimately lead to fracture.

US Patent:

20100240642, Sep 23, 2010

Filed:

Aug 31, 2007

Appl. No.:

12/438024

Inventors:

Jeffrey Alan Oplinger - Durham NC, US
Paul Kenneth Spearing - Durham NC, US
Millard Hurst Lambert - Durham NC, US
John A. Ray - Durham NC, US
Christopher P. Laudeman - Durham NC, US
Jerzy R. Szewczyk - Durham NC, US
Pierette Banker - Durham NC, US

Assignee:

SMITHKLINE BEECHAM CORPORATION - PHILADELPHIA PA

International Classification:

A61K 31/404
C07D 209/42
C07D 401/04
C07D 413/10
C07D 409/12
C07D 403/10
C07D 417/10
A61K 31/4439
A61K 31/5377
A61K 31/496
A61K 31/541
A61P 3/10

US Classification:

5142282, 548492, 5462781, 544143, 548465, 544373, 544 585, 544 582, 514419, 514339, 5142352, 514414, 51425409

Abstract:

The present invention relates to certain indole derivatives that are modulators of PPARγ, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.

US Patent:

20110118261, May 19, 2011

Filed:

Dec 10, 2008

Appl. No.:

12/747186

Inventors:

Scott Allen - Durham NC, US
Eric Boros - Durham NC, US
Jon L. Collins - Durham NC, US
Don Hertzog - Durham NC, US
Xi Liang - Durham NC, US
John Ray - Durham NC, US
Steven Michael Reister - Durham NC, US
Vicente Samano - Durham NC, US
Ron Sherrill - Durham NC, US

International Classification:

A61K 31/5377
C07D 401/14
C07D 413/14
C07D 405/14
A61K 31/444
A61K 31/4545
A61P 3/10
A61P 3/04
A61P 9/12
A61P 25/24
A61P 25/22
A61P 25/30

US Classification:

5142355, 546256, 544131, 546193, 514333, 514318

Abstract:

The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

US Patent:

20110301203, Dec 8, 2011

Filed:

Aug 19, 2011

Appl. No.:

13/213978

Inventors:

Philip Stewart Turnbull - Durham NC, US
Rodolfo Cadilla - Durham NC, US
Andrew Larkin - Durham NC, US
Eugene L. Stewart - Durham NC, US
Katherine Stetson - Durham NC, US
Darryl Lynn McDougald - Durham NC, US
Amarjit Sab Randhawa - Durham NC, US
John A. Ray - Durham NC, US

Assignee:

GLAXOSMITHKLINE LLC - Philadelphia PA

International Classification:

A61K 31/4439
C07D 413/14
C07D 417/14
A61K 31/4245
A61K 31/433
A61P 5/00
A61P 19/10
A61P 21/00
A61P 35/00
A61P 43/00
A61P 15/00
A61P 25/24
A61P 7/00
A61P 17/10
C07D 413/06

US Classification:

514339, 548131, 5462694, 548127, 548143, 514364

Abstract:

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.