John E Sanborn

US Patent:

20120059670, Mar 8, 2012

Filed:

May 25, 2011

Appl. No.:

13/134047

Inventors:

John Zachary Sanborn - Santa Cruz CA, US
David Haussler - Santa Cruz CA, US

International Classification:

G06F 19/18
G06Q 50/22

US Classification:

705 3, 702 19

Abstract:

The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime. The methods may also be used to evaluate protein and/or metabolite levels that correlate with such clinical conditions. The methods are also of use to ascertain the probability outcome for a patient's particular prognosis.

US Patent:

20120066001, Mar 15, 2012

Filed:

Nov 18, 2011

Appl. No.:

13/373550

Inventors:

John Zachary Sanborn - Santa Cruz CA, US
David Haussler - Santa Cruz CA, US

International Classification:

G06Q 50/24
G06F 19/22

US Classification:

705 3, 702 19

Abstract:

A differential sequence object is constructed on the basis of alignment of sub-strings via incremental synchronization of sequence strings using known positions of the sub-strings relative to a reference genome sequence. An output file is then generated that comprises only relevant changes with respect to the reference genome.

US Patent:

20200227137, Jul 16, 2020

Filed:

Aug 25, 2016

Appl. No.:

15/755096

Inventors:

- Culver City CA, US
John Zachary Sanborn - Santa Cruz CA, US

International Classification:

G16B 20/20
G16B 10/00
G16B 40/00
G16B 20/10
G16B 5/20
G16H 10/40
G16H 50/20
G16H 70/60
G16H 50/50

Abstract:

Contemplated systems and methods use identification and classification of somatic single nucleotide variants found in a primary tumor and metastases to determine phylogeny of the metastases.

US Patent:

20200093907, Mar 26, 2020

Filed:

Sep 13, 2019

Appl. No.:

16/571008

Inventors:

- Culver City CA, US
Andrew Nguyen - San Jose CA, US
Charles Joseph Vaske - Santa Cruz CA, US
John Zachary Sanborn - Santa Cruz CA, US

International Classification:

A61K 39/00
C12N 5/0783
A61K 47/68
C07K 14/47
C07K 16/22
G01N 33/574
C07K 16/30
C12N 5/09

Abstract:

Certain universal neoepitopes and cancer specific neoepitopes and methods therefore are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells.

US Patent:

20190325997, Oct 24, 2019

Filed:

Jul 2, 2019

Appl. No.:

16/460325

Inventors:

- Culver City CA, US
John Zachary Sanborn - Santa Cruz CA, US
Stephen Charles Benz - Santa Cruz CA, US
Charles Joseph Vaske - Santa Cruz CA, US

International Classification:

G16H 10/60
G06Q 50/22

Abstract:

Healthcare object (HCO) discriminator systems and methods are presented. Systems can obtain a digital representation of a scene via a sensor interface. An HCO discriminator platform analyzes the digital representation to discriminate objects within the scene as being associated with a type of HCO or as being unrelated to a type of HCO. Once the HCO recognition platform determines that a type of HCO is relevant, it instantiates an actual HCO. The HCO can be routed to one or more destinations based on routing rules generated from a template or based on the manner in which the objects in the scene were discriminated.

US Patent:

20190237196, Aug 1, 2019

Filed:

Aug 25, 2017

Appl. No.:

16/327802

Inventors:

- Culver City CA, US
John Zachary Sanborn - Santa Cruz CA, US
Shahrooz Rabizadeh - Los Angeles CA, US

International Classification:

G16H 50/30
G16B 20/20
G16B 30/10
C12Q 1/6827
C12Q 1/6869
G16B 40/00
G16H 50/20

Abstract:

Systems and methods for prediction of the treatment outcome for immune therapy are presented in which omics data of a patient tumor sample are used. Most typically, the omics data are processed to identify mutational signatures (especially APOBEC/POLE signatures), immune checkpoint expression, and MSI status as leading indicators to predict the treatment outcome for immune therapy. Such prediction advantageously integrates various parameters that would otherwise, when individually considered, skew prediction outcome.

US Patent:

20190099475, Apr 4, 2019

Filed:

Apr 8, 2016

Appl. No.:

15/565203

Inventors:

- Culver City CA, US
Andrew Nguyen - San Jose CA, US
Charles Joseph Vaske - Santa Cruz CA, US
John Zachary Sanborn - Santa Cruz CA, US

International Classification:

A61K 39/00
C12N 5/0783

Abstract:

Certain universal neoepitopes and cancer specific neoepitopes and methods therefor are presented that may be used in immunotherapy and cancer diagnosis. Preferred therapeutic and diagnostic compositions include antibodies or fragments thereof that bind to neoepitopes on cancer cells.

US Patent:

20190066262, Feb 28, 2019

Filed:

Oct 24, 2018

Appl. No.:

16/169946

Inventors:

- Culver City CA, US
John Zachary Sanborn - Santa Cruz CA, US
Stephen Charles Benz - Santa Cruz CA, US

International Classification:

G06T 3/40
G06F 19/26
G09G 5/373
G06F 19/22
G06F 19/28

Abstract:

Systems and methods for dynamic visualization of genomic data are provided in which a genomic visualization system adapts presentation of information content according to scale-relevant annotations within a sequence object.