John Joseph Shay

US Patent:

20030069423, Apr 10, 2003

Filed:

May 10, 2002

Appl. No.:

10/143611

Inventors:

Timothy Ayers - Bridgewater NJ, US
Geoffrey D'Netto - Hillsborough NJ, US
Gregory Kubiak - Easton PA, US
James Mencel - North Wales PA, US
Michael O'Brien - Berwyn PA, US
Matthew Powers - Barto PA, US
John Shay - Bethlehem PA, US
Adam Sledeski - Belle Mead NJ, US
David Teager - Marcus Hook PA, US
Benoit Vanasse - New Hope PA, US

International Classification:

C07D473/34
C07D471/02
A61K031/52

US Classification:

544/277000, 514/210210, 514/263200, 514/263220, 514/263240, 546/118000, 514/303000

Abstract:

Novel processes for the preparation of adenosine compounds and intermediates thereto. The adenosine compounds prepared by the present processes may be useful as cardiovascular agents, more particularly as antihypertensive and anti-ischemic agents, as cardioprotective agents which ameliorate ischemic injury or myocardial infarct size consequent to myocardial ischemia, and as an antilipolytic agents which reduce plasma lipid levels, serum triglyceride levels, and plasma cholesterol levels. The present processes may offer improved yields, purity, ease of preparation and/or isolation of intermediates and final product, and more industrially useful reaction conditions and workability.