John Gordon Smart

US Patent:

7056882, Jun 6, 2006

Filed:

Sep 13, 2001

Appl. No.:

09/952318

Inventors:

Charles M. Cohen - Weston MA, US
Herrmann Oppermann - Medway MA, US
Engin Ozkaynak - Milford MA, US
David C. Rueger - Hopkinton MA, US
John E. Smart - Weston MA, US
Roy H. L. Pang - Etna NH, US

Assignee:

Curis, Inc. - Cambridge MA

International Classification:

A61K 38/18
A61K 38/16

US Classification:

514 2, 514 12, 424 851

Abstract:

The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.

US Patent:

59941316, Nov 30, 1999

Filed:

Aug 15, 1997

Appl. No.:

8/912088

Inventors:

John E. Smart - Weston MA
Hermann Oppermann - Medway MA
Engin Ozkaynak - Milford MA
David C. Rueger - Hopkinton MA
Roy H. L. Pang - Etna NH
Charles M. Cohen - Medway MA

Assignee:

Creative BioMolecules, Inc. - Hopkinton MA

International Classification:

C12N 506
C12N 508

US Classification:

435354

Abstract:

Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.

US Patent:

63333120, Dec 25, 2001

Filed:

Oct 13, 1998

Appl. No.:

9/170936

Inventors:

Charles M. Cohen - Weston MA
Herrmann Oppermann - Medway MA
Engin Ozkaynak - Milford MA
David C. Rueger - Hopkinton MA
John E. Smart - Weston MA
Roy H. L. Pang - Etna NH

Assignee:

Curis, Inc.

International Classification:

C07K 14435
C07K 14475

US Classification:

514 12

Abstract:

The invention is a treatment for increasing the bone mass or preventing bone loss in an individual afflicted with a bone disease which includes administering to the individual a morphogen in a therapeutically effective amount so as to maintain or stimulate bone formation.

US Patent:

56502761, Jul 22, 1997

Filed:

Jul 20, 1994

Appl. No.:

8/278729

Inventors:

John E. Smart - Weston MA
Hermann Oppermann - Medway MA
Engin Ozkaynak - Milford MA
David C. Rueger - Hopkinton MA
Roy H.L. Pang - Etna NH
Charles M. Cohen - Medway MA

Assignee:

Creative BioMolecules, Inc. - Hopkinton MA

International Classification:

C12Q 168
C12Q 102

US Classification:

435 6

Abstract:

Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.

US Patent:

57416419, Apr 21, 1998

Filed:

May 26, 1995

Appl. No.:

8/451953

Inventors:

John E. Smart - Weston MA
Hermann Oppermann - Medway MA
Engin Ozkaynak - Milford MA
David C. Rueger - Hopkinton MA
Roy H. L. Pang - Etna NH
Charles M. Cohen - Medway MA

Assignee:

Creative BioMolecules, Inc. - Hopkinton MA

International Classification:

C12Q 168
G01N 3353

US Classification:

435 6

Abstract:

Disclosed is a method of screening candidate compounds for the ability to modulate the level of morphogenic protein in mammalian system. The method includes determining a parameter indicative of the level of production of a morphogenic in a cell culture known to produce the morphogen, incubating a candidate compound with the culture for a time sufficient to allow the compound to affect the production of the morphogenic protein, and then assaying the culture again to detect a change in the level of morphogenic protein production.

US Patent:

57078106, Jan 13, 1998

Filed:

May 6, 1996

Appl. No.:

8/643563

Inventors:

John E. Smart - Weston MA
Hermann Oppermann - Medway MA
Engin Ozkaynak - Milford MA
David C. Rueger - Hopkinton MA
Roy H. L. Pang - Etna NH
Charles M. Cohen - Medway MA

Assignee:

Creative BioMolecules, Inc. - Hopkinton MA

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

In one aspect, the present invention provides a method of diagnosing renal tissue damage or disease by measuring endogenous expression of OP-1 by renal tissue of a mammal (e. g. , a human) in which a depression of endogenous expression relative to undamaged or undiseased mammalian renal tissue indicates a diagnosis that the mammal is afflicted with renal tissue damage or disease. Also disclosed are methods of diagnosing renal tissue damage or disease in a mammal. The methods involve detecting and/or measuring the expression of the OP-1 (BMP-7) gene or protein in the mammal. Depression of OP-1 expression may be used to diagnose renal tissue damage or disease.