John D Sowell

US Patent:

20090104705, Apr 23, 2009

Filed:

May 23, 2006

Appl. No.:

11/920498

Inventors:

Jan Frederik Stevens - Corvallis OR, US
John D. Sowell - Corvallis OR, US
Balz Frei - Corvallis OR, US

International Classification:

G01N 33/00

US Classification:

436 63, 436129, 436 93

Abstract:

Oxidative stress, resulting from the generation of reactive oxygen species, contributes to the development of a multitude of age-related diseases. Current methods of assessing oxidative stress levels range from the detection of lipid peroxidation products, such as F-isoprostanes and malondialdehyde, to monitoring the redox status of glutathione. While useful, traditional biomarkers of oxidative stress are not without their drawbacks, including low in vitro concentrations and possible artifact formation. Disclosed herein are new marker compounds, including ascorbylated 4-hydroxy-2-nonenal, that are useful as biomarkers of oxidative stress.