John T Trent

US Patent:

7314926, Jan 1, 2008

Filed:

Apr 7, 2000

Appl. No.:

09/958251

Inventors:

Donald M. Miller - Louisville KY, US
Paula J. Bates - Louisville KY, US
John O. Trent - Louisville KY, US

Assignee:

Antisoma Research Limited - London

International Classification:

C07H 21/04
A61K 48/00

US Classification:

536 241, 536 231, 514 44

Abstract:

The present invention provides a method for inhibiting the proliferation of malignant and/or hyperplastic cells in a subject by administering to the subject a therapeutically effective amount of a guanosine rich oligonucleotide. The present invention also provides oligonucleotides which are capable of being specifically bound to a specific cellular protein which is nucleolin and/or nucleolin-like in nature, which is implicated in the proliferation of cells, specifically malignant and/or hyperplastic cells, and a method for their selection.

US Patent:

7357928, Apr 15, 2008

Filed:

Oct 9, 2003

Appl. No.:

10/683480

Inventors:

Paula J. Bates - Louisville KY, US
Donald M. Miller - Louisville KY, US
John O. Trent - Louisville KY, US
Xiaohua Xu - Louisville KY, US

Assignee:

University of Louisville Research Foundation, Inc. - Louisville KY

International Classification:

A61K 39/395
A61K 51/00
A01N 61/00

US Classification:

4241301, 424 111, 514 1

Abstract:

Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.

US Patent:

7541150, Jun 2, 2009

Filed:

Apr 8, 2002

Appl. No.:

10/118854

Inventors:

Donald M. Miller - Louisville KY, US
Paula J. Bates - Louisville KY, US
John O. Trent - Louisville KY, US
Xiaohua Xu - Louisville KY, US

Assignee:

University of Louisville Research Foundation, Inc - Louisville KY

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

Methods for the diagnosis of cancer by determining the neoplastic status of a cell by probing the cell plasma membrane for the presence of nucleolin are provided, as are kits to carry out such tests.

US Patent:

7960540, Jun 14, 2011

Filed:

Oct 31, 2007

Appl. No.:

11/982427

Inventors:

John O. Trent - Louisville KY, US
Paula J. Bates - Louisville KY, US
Donald M. Miller - Louisville KY, US

Assignee:

Advanced Cancer Therapeutics, LLC - Louisville KY

International Classification:

C07H 21/00
C07H 21/02

US Classification:

536 245, 536 231, 536 243, 536 2433

Abstract:

Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.

US Patent:

8029784, Oct 4, 2011

Filed:

Mar 4, 2008

Appl. No.:

12/041969

Inventors:

Paula J. Bates - Louisville KY, US
Donald M. Miller - Louisville KY, US
John O. Trent - Louisville KY, US
Xiaohua Xu - Louisville KY, US

Assignee:

University of Louisville Research Foundation, Inc. - Louisville KY

International Classification:

A61K 39/395

US Classification:

4241301, 424 111

Abstract:

Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.

US Patent:

8088385, Jan 3, 2012

Filed:

Jun 18, 2008

Appl. No.:

12/141751

Inventors:

Jason Chesney - Louisville KY, US
John O. Trent - Louisville KY, US
Sucheta Telang - Louisville KY, US
Brian Clem - Louisville KY, US
Jason Meier - Louisville KY, US

Assignee:

University of Louisville Research Foundation Inc. - Louisville KY

International Classification:

A01N 43/40
A61K 31/44
A61K 39/395

US Classification:

4241741, 514332

Abstract:

A methods and compounds for inhibiting 6-phosphofructo-2-kinase /fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.

US Patent:

8114850, Feb 14, 2012

Filed:

Oct 31, 2007

Appl. No.:

11/982413

Inventors:

John O. Trent - Louisville KY, US
Paula J. Bates - Louisville KY, US
Donald J. Miller - Louisville KY, US

Assignee:

Advanced Cancer Therapeutics, LLC - Louisville KY

International Classification:

A01N 43/04
C07H 21/04

US Classification:

514 44R, 435375, 536 241

Abstract:

Compositions and methods for modulating tumor proliferation in an individual are provided. The methods employ nucleolin-binding agents, such as aptamers. The aptamers of the present invention can be used to modulate the proliferation of malignant, dysplastic, hyperproliferative, and/or metastatic cells through interference with molecular interactions and functions of nucleolin in the tumor cell.

US Patent:

8557823, Oct 15, 2013

Filed:

Nov 30, 2011

Appl. No.:

13/307552

Inventors:

Gilles Tapolsky - Louisville KY, US
Pooran Chand - Birmingham AL, US
John O. Trent - Louisville KY, US
Sucheta Telang - Louisville KY, US
Brian F. Clem - Louisville KY, US
Jason A. Chesney - Louisville KY, US

Assignee:

Advanced Cancer Therapeutics, LLC - Louisville KY
University of Louisville Research Foundation, Inc. - Louisville KY

International Classification:

A01N 43/42
A61K 31/47
A61K 31/497
C07D 215/12
C07D 215/14

US Classification:

51425308, 514311, 514314, 546174

Abstract:

A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.