John Frederick Wolfe

US Patent:

6395916, May 28, 2002

Filed:

Jul 10, 1998

Appl. No.:

09/113478

Inventors:

Stephen L. Buchwald - Newton MA
John P. Wolfe - Brighton MA
David W. Old - Somerville MA
Ken Kamikawa - Brookline MA
Michael Palucki - Belle Meade NJ

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07F 704

US Classification:

556413, 564 15, 568 13, 568 14, 568 17, 568423

Abstract:

One aspect of the present invention relates to novel, electron-rich bidentate ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.

US Patent:

6528306, Mar 4, 2003

Filed:

Sep 20, 1999

Appl. No.:

09/398298

Inventors:

Evan Y. Snyder - Jamaica Plain MA
John H. Wolfe - Philadelphia PA
Seung U. Kim - Vancouver, CA

Assignee:

The Childrens of Medical Center Corporation - Boston MA
The University of British Columbia
The University of Pennsylvania - Philadelphia PA

International Classification:

C12N 510

US Classification:

435368, 435455

Abstract:

Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations. Further supporting their potential for gene therapeutic applications, the secretory products from these NSCs can cross-correct a prototypical genetic metabolic defect in abnormal neurons and glia in vitro as effectively as do murine NSCs.

US Patent:

6541255, Apr 1, 2003

Filed:

Sep 20, 1999

Appl. No.:

09/398297

Inventors:

Evan Y. Snyder - Jamaica Plain MA
John H. Wolfe - Philadelphia PA
Seung U. Kim - Vancouver, CA

Assignee:

The Childrens Medical Center Corporation - Boston MA
The University of British Columbia
The University of Pennsylvania - Philadelphia PA

International Classification:

C12N 508

US Classification:

435368, 514 44

Abstract:

Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations. Further supporting their potential for gene therapeutic applications, the secretory products from these NSCs can cross-correct a prototypical genetic metabolic defect in abnormal neurons and glia in vitro as effectively as do murine NSCs.

US Patent:

6680198, Jan 20, 2004

Filed:

Sep 20, 1999

Appl. No.:

09/398299

Inventors:

Evan Y. Snyder - Jamaica Plain MA
John H. Wolfe - Philadelphia PA
Seung U. Kim - Vancouver, CA

Assignee:

The Childrens Medical Center Corporation - Boston MA
University of British Columbia - Vancouver
University of Pennsylvania - Philadelphia PA

International Classification:

C12N 508

US Classification:

435368, 424 937

Abstract:

Stable clones of neural stem cells (NSCs) have been isolated from the human fetal telencephalon. In vitro, these self-renewing clones (affirmed by retroviral insertion site) can spontaneously give rise to all 3 fundamental neural cell types (neurons, oligodendrocytes, astrocytes). Following transplantation into germinal zones of the developing newborn mouse brain, they, like their rodent counterparts, can participate in aspects of normal development, including migration along well-established migratory pathways to disseminated CNS regions, differentiation into multiple developmentally- and regionally-appropriate cell types in response to microenvironmental cues, and non-disruptive, non-tumorigenic interspersion with host progenitors and their progeny. Readily genetically engineered prior to transplantation, human NSCs are capable of expressing foreign transgenes in vivo in these disseminated locations. Further supporting their potential for gene therapeutic applications, the secretory products from these NSCs can cross-correct a prototypical genetic metabolic defect in abnormal neurons and glia in vitro as effectively as do murine NSCs.

US Patent:

6867310, Mar 15, 2005

Filed:

Jan 27, 1999

Appl. No.:

09/239024

Inventors:

Stephen L. Buchwald - Newton MA, US
John P. Wolfe - Brighton MA, US
Jens Ahman - Sandwich, GB
Malisa Troutman - Irvington NY, US
Michael Palucki - Belle Meade NJ, US
Ken Kamikawa - Brookline MA, US
Andre Chieffi - Somerville MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D317/44

US Classification:

549453, 549446, 568316, 568312, 564169, 564275, 556143, 556144, 548540, 560 82

Abstract:

The present invention provides transition-metal-catalyst-based methods for the arylation and vinylation of activated methyl, methylene, and methine carbons with aryl halides, vinyl halides, and the like. The methods of the invention provide several improvements over existing methods, including the ability to synthesize efficiently and under mild conditions α-aryl and α-vinyl products from a wide range of starting materials, including ketones, esters, hydrazones, and imines. Furthermore, the methods of the invention may be used in an asymmetric sense, i. e. to produce enantiomerically-enriched chiral α-aryl and α-vinyl products.

US Patent:

6946560, Sep 20, 2005

Filed:

Apr 22, 2003

Appl. No.:

10/420950

Inventors:

Stephen L. Buchwald - Newton MA, US
David W. Old - Somerville MA, US
John P. Wolfe - Brighton MA, US
Michael Palucki - Belle Meade NJ, US
Ken Kamikawa - Brookline MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D211/70
C07D207/04
C07F015/00
C07C209/00

US Classification:

546339, 548577, 556 13, 556136, 564405

Abstract:

One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.

US Patent:

7026498, Apr 11, 2006

Filed:

Oct 23, 2001

Appl. No.:

10/004101

Inventors:

Stephen L. Buchwald - Newton MA, US
David W. Old - Somerville MA, US
John P. Wolfe - Brighton MA, US
Michael Palucki - Belle Meade NJ, US
Ken Kamikawa - Brookline MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07F 7/04
C07F 9/02
C07C 255/47
C07C 273/02

US Classification:

556413, 558415, 558420, 558421, 564 64, 564428, 568 17

Abstract:

One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.

US Patent:

7247731, Jul 24, 2007

Filed:

Sep 16, 2005

Appl. No.:

11/229043

Inventors:

Stephen L. Buchwald - Newton MA, US
David W. Old - Somerville MA, US
John P. Wolfe - Brighton MA, US
Michael Palucki - Belle Meade NJ, US
Ken Kamikawa - Brookline MA, US

Assignee:

Massachusetts Institute of Technology - Cambridge MA

International Classification:

C07D 211/70
C07F 7/04
C07F 9/02

US Classification:

546339, 556413, 564 15

Abstract:

One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.