Jonathan Michael Chen

US Patent:

20190324028, Oct 24, 2019

Filed:

Mar 6, 2019

Appl. No.:

16/294853

Inventors:

- New Haven CT, US
Yao Lu - New Haven CT, US
Jonathan Chen - San Jose CA, US

Assignee:

Yale University - New Haven CT

International Classification:

G01N 33/543

Abstract:

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

US Patent:

20190166404, May 30, 2019

Filed:

Nov 30, 2017

Appl. No.:

15/828250

Inventors:

- Menlo Park CA, US
Russell Aaron Phillips - San Francisco CA, US
Heping Gao - Issaquah WA, US
Jonathan E. Chen - Seattle WA, US
Abhishek Bapna - Mountain View CA, US

International Classification:

H04N 21/472
G06Q 50/00
G06F 17/30
G06Q 30/02
H04N 21/234
H04L 29/08

Abstract:

In one embodiment, a method includes a computer server machine receiving a request from a first user to interact with a multimedia content. The computer server machine then associates the first user with a control group, wherein the control group comprises a first set of users interacting with the multimedia content. When the first user is associated with the control group, the computer server machine then applies a first content insertion model to the multimedia content and records a first set of metrics based on the interaction of the first user with the multimedia content.

US Patent:

20170067887, Mar 9, 2017

Filed:

Oct 11, 2016

Appl. No.:

15/290874

Inventors:

- New Haven CT, US
Yao Lu - New Haven CT, US
Jonathan Chen - San Jose CA, US

Assignee:

Yale University - New Haven CT

International Classification:

G01N 33/543

Abstract:

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

US Patent:

20150204862, Jul 23, 2015

Filed:

Dec 5, 2014

Appl. No.:

14/562061

Inventors:

- New Haven CT, US
Yao Lu - New Haven CT, US
Jonathan Chen - San Jose CA, US

International Classification:

G01N 33/543

Abstract:

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

US Patent:

20150204864, Jul 23, 2015

Filed:

Feb 23, 2015

Appl. No.:

14/629164

Inventors:

- New Haven CT, US
Yao LU - New Haven CT, US
Jonathan Chen - San Jose CA, US

Assignee:

Yale University - New Haven CT

International Classification:

G01N 33/543

Abstract:

The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.