Jonathan A Cherry

US Patent:

20130096160, Apr 18, 2013

Filed:

Apr 14, 2011

Appl. No.:

13/641383

Inventors:

Juan Jose Marugan - Gaithersburg MD, US
Jingbo Xiao - Rockville MD, US
Steven A. Titus - Elkridge MD, US
Noel Southall - Chevy Chase MD, US
Wei Zheng - Potomac MD, US
Elliot J. Androphy - Natick MA, US
Jonathan Cherry - Worcester MA, US

Assignee:

Secretary, Department of Health and Human Services - Bethesda MD

International Classification:

C07D 417/04

US Classification:

514326, 546209

Abstract:

Aryl substituted thiazol-2-yl-piperidines and related compounds useful as modulators of survival motor neuron (SMN) protein production are provided herein. Without being bound to any particular theory it is believed the aryl substituted thiazol-2-yl-piperidines and related compounds provided herein act to increase production of the SMN2 form of survival motor neuron protein. These compounds are useful for treating spinal muscular atrophy. Pharmaceutical compositions containing a carrier and one or more of the aryl substituted thiazol-2-yl-piperidine or related compounds described herein are also provided. Methods of treating spinal muscular atrophy are also provided by this disclosure.