Jonathan C Day

US Patent:

8454971, Jun 4, 2013

Filed:

Feb 13, 2008

Appl. No.:

12/527140

Inventors:

Jonathan Day - San Diego CA, US
James Patterson - Bloomington IN, US
Joseph Chabenne - Fishers IN, US
Maria Dimarchi - Carmel IN, US
David L. Smiley - Bloomington IN, US
Richard D. Dimarchi - Carmel IN, US

Assignee:

Indiana University Research and Technology Corporation - Indianapolis IN

International Classification:

A61K 38/26
C07K 14/605

US Classification:

4241981, 530399

Abstract:

Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming lactam bridges or the substitution of the terminal carboxylic acid with an amide group produces peptides exhibiting glucagon/GLP-1 receptor co-agonist activity. The solubility and stability of these high potency glucagon analogs can be further improved by modification of the polypeptides by pegylation, substitution of carboxy terminal amino acids, or the addition of a carboxy terminal peptide selected from the group consisting of SEQ ID NO: 26 (GPSSGAPPPS), SEQ ID NO: 27 (K-RNRNNIA) and SEQ ID NO: 28 (KRNR).

US Patent:

20120323558, Dec 20, 2012

Filed:

Sep 21, 2011

Appl. No.:

13/239180

Inventors:

JAMES J. NOLAN - SPRINGFIELD VA, US
MARK E. FRYMIRE - ARLINGTON VA, US
JONATHAN C. DAY - SPRINGFIELD VA, US
Peter F. David - Herndon VA, US

Assignee:

DECISIVE ANALYTICS CORPORATION - ARLINGTON VA

International Classification:

G06F 17/27

US Classification:

704 9, 704E11001

Abstract:

A method for creating a predictive model is disclosed herein, including the steps of determining trends and patterns in electronic data, using at least a first machine language algorithm, refining the determination of the algorithm, searching for social models that describe the identified trends and patterns using at least a second machine language algorithm, verifying causal links, constructing at least one model about human node behavior and interactions, utilizing the social models to do at least one of the following: validate hypotheses, predict future behavior, and examine hypothetical scenarios, and automatically updating predictions when new data is introduced.

US Patent:

59438150, Aug 31, 1999

Filed:

Mar 14, 1997

Appl. No.:

8/816437

Inventors:

Joseph Paganessi - Burr Ridge IL
Robert Lee - Calgary, CA
Jonathan F. Day - Vero Beach FL

Assignee:

University of Florida - Gainesville FL
Air Liquide Canada - Montreal
TMJ Enterprises, Inc. - Burr Ridge IL

International Classification:

A01M 102

US Classification:

43107

Abstract:

A method and delivery system for an area-specific precision control of biting insects, including flying and non-flying, biting arthropods, is described. CO. sub. 2 is metered through a tubing fence and dispensed into the center of traps that serve as visual targets for flying or walking biting arthropods. The outside membrane of a trap can be treated with mineral oil to capture and kill small arthropods such as sand flies of the genus Culicoides, or black flies of the genus Simulium. In addition, the membrane can be treated with insecticide formulations of Permethrin, Resmethrin, or Deltamethrin, to kill larger biting arthropods, such as ticks, mosquitoes, deer flies, horse flies, or stable flies. This method for biting arthropod control is an ecological-friendly alternative to the widespread broadcast application of organophosphate insecticides such as Derspan, Diprom, and Maithion.

US Patent:

62727907, Aug 14, 2001

Filed:

May 21, 1999

Appl. No.:

9/315993

Inventors:

Joseph Paganessi - Burr Ridge IL
Robert Lee - Calgary, CA
Jonathan F. Day - Vero Beach FL

Assignee:

University of Florida - Gainesville FL
Air Liquide Canada - Montreal
TMJ Enterprises, Inc. - Burr Ridge IL

International Classification:

A01M 102

US Classification:

43107

Abstract:

A method and delivery system for an area-specific precision control of biting insects, including flying and non-flying, biting arthropods, is described. CO. sub. 2 is metered through a tubing fence and dispensed into the center of traps that serve as visual targets for flying or walking biting arthropods. The outside membrane of a trap can be treated with mineral oil to capture and kill small arthropods such as sand flies of the genus Culicoides, or black flies of the genus Simulium. In addition, the membrane can be treated with insecticide formulations of Permethrin, Resmethrin, or Deltamethrin, to kill larger biting arthropods, such as ticks, mosquitoes, deer flies, horse flies, or stable flies. This method for biting arthropod control is an ecological-friendly alternative to the widespread broadcast application of organophosphate insecticides such as Derspan, Diprom, and Malthion.

US Patent:

20220211818, Jul 7, 2022

Filed:

Jan 18, 2022

Appl. No.:

17/577932

Inventors:

- Indianapolis IN, US
John Michael Beals - Solana Beach CA, US
Jonathan Wesley Day - Carmel IN, US
Craig Duane Dickinson - San Diego CA, US
Andrew Ihor Korytko - Oceanside CA, US
Gregory Alan Lazar - Pacifica CA, US

International Classification:

A61K 38/28
C07K 14/62
A61K 38/16
A61K 38/26
C07K 14/00

Abstract:

The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.