Jonathan Michael Greene

US Patent:

20080154567, Jun 26, 2008

Filed:

Dec 19, 2007

Appl. No.:

11/959536

Inventors:

Ping Qiu - Edison NJ, US
Jonathan Richard Greene - South Orange NJ, US
Wei Ding - Scotch Plains NJ, US
Qing Zhang - Short Hills NJ, US

International Classification:

G06G 7/58

US Classification:

703 11

Abstract:

The present invention relates to a method for developing algorithms that are capable of discriminating among different genotypes and subtypes of a virus of interest. The method includes aligning a set of viral nucleotide sequences having known genotypes and analyzing the aligned sequences to identify nucleotide positions at which the nucleotide is conserved within genotypes, but diversified across the different known genotypes. These positions, referred to herein as genotyping positions, are employed as predictive variables to compile a variable input table for analysis by a statistical classification algorithm. The variable input table also includes the nucleotide present at each genotyping position as a value and the genotype for each of the aligned sequences as a response variable. The algorithm analyzes the sequences of nucleotides at the genotyping positions across the aligned viral sequences, and uses the results of this analysis to specify parameters for each genotyping position that when combined across the genotyping positions will discriminate among the genotypes represented in the input sequences. The algorithm generated by this method is useful in a method of predicting the genotype of a viral isolate of interest, such as a virus present in a biological sample obtained from an individual.

US Patent:

56419562, Jun 24, 1997

Filed:

Feb 2, 1996

Appl. No.:

8/595734

Inventors:

Ashish M. Vengsarkar - Berkeley Heights NJ
Vikram Bhatia - Blacksburg VA
Jonathan A. Greene - Blacksburg VA
Kent A. Murphy - Troutville VA

Assignee:

F&S, Inc. - Blacksburg VA
Lucent Technologies - Murray Hill NJ

International Classification:

H01J 516

US Classification:

25022714

Abstract:

An optical waveguide sensor arrangement for sensing at least one physical parameter is provided. This arrangement comprises an optical waveguide having guided modes, lossy non-guided modes, and a long period grating coupling the guided modes to the lossy non-guided modes wherein the long period grating produces a wavelength transmission spectrum functionally dependent on the physical parameter sensed. A source means provides light to the optical waveguide sensor and an optoelectronic detector, which is positioned in an operable relationship to the optical waveguide sensor, detects light transmitted through the optical waveguide sensor. Lastly, a processing means is attached to the optoelectronic detector for correlating the wavelength transmission spectrum with a numerical value for the physical parameter sensed. The physical parameters sensed by the optical waveguide sensor include: temperature, strain, shape, refractive index and corrosion.