Jonathan A Hodges

Address:

8528 Yucca Trl, Raleigh, NC 27615

VIN:

JTDKB20U273224509

Make:

TOYOTA

Model:

PRIUS

Year:

2007

US Patent:

7122521, Oct 17, 2006

Filed:

Jun 23, 2004

Appl. No.:

10/874725

Inventors:

Ronald T. Raines - Madison WI, US
Jonathan A. Hodges - Madison WI, US

Assignee:

Wisconsin Alumni Research Foundation - Madison WI

International Classification:

A61K 38/00
A61K 38/06
C07K 5/00

US Classification:

514 12, 514 2, 530331, 530329, 530345, 530356

Abstract:

A novel collagen mimic comprising a tripeptide unit having the formula (flpYaaGly), where flp is 4(S)-fluoro-L-proline, is disclosed. The collagen mimic has increased stability relative to the collagen-related triple helices (ProYaaGly), (hypYaaGly), and (HypYaaGly).

US Patent:

20070275897, Nov 29, 2007

Filed:

May 25, 2007

Appl. No.:

11/807270

Inventors:

Ronald Raines - Madison WI, US
Matthew Shoulders - Madison WI, US
Jonathan Hodges - Raleigh NC, US

International Classification:

A61K 38/39
C07K 7/06
C07K 7/08

US Classification:

514012000, 514013000, 514014000, 514015000, 530324000, 530325000, 530326000, 530327000, 530328000

Abstract:

Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly), where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.

US Patent:

20110117165, May 19, 2011

Filed:

Nov 18, 2010

Appl. No.:

12/948978

Inventors:

Mora Carolynne Melican - Cary NC, US
Paul Theodore Hamilton - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Yuchen Chen - Chapel Hill NC, US

Assignee:

AFFINERGY, INC. - Research Triangle Park NC

International Classification:

A61F 2/00
A61K 33/06
A61K 33/42
A61K 33/10
A61K 31/74

US Classification:

424423, 424682, 424602, 424687, 424 7808

Abstract:

Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached BMP binding peptide. In addition, an implantable bone graft material is provided consisting essentially of a resorbable β-TCP and a resorbable polymer, wherein the β-TCP has a total porosity of about 50% or greater and wherein the β-TCP has a particle size ranging from about 100 micron to about 300 micron. The implantable bone graft materials are useful for promoting bone growth in a subject.

US Patent:

20110117167, May 19, 2011

Filed:

Nov 18, 2010

Appl. No.:

12/949104

Inventors:

Isaac Gilliam Sanford - Durham NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Yuchen Chen - Chapel Hill NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Hanne Gron - Durham NC, US
Ganesan Sathya - Cary NC, US

Assignee:

AFFINERGY, INC. - Research Triangle Park NC

International Classification:

A61K 9/00
C07K 14/00
C07K 7/08
C07K 14/78
C12N 5/071
C12N 5/078
A61K 35/12
A61K 35/32
A61K 35/28
A61K 35/14
A61K 35/16
A61K 35/48
A61K 35/50
C07K 19/00
A61K 38/16
A61K 38/10
A61K 38/39
A61P 17/02
A61P 19/04
A61P 21/00
A61P 19/00
A61P 9/00
C07K 9/00
C08G 63/91
A61K 38/14
A61K 31/765
C12N 5/077

US Classification:

424423, 530326, 530327, 530356, 435325, 424 937, 424 9372, 530324, 530357, 514 214, 514 215, 514 172, 424 7817, 514 94, 514 82, 514 186, 530322, 530353, 525 541, 514 209, 424 783

Abstract:

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

US Patent:

20110117168, May 19, 2011

Filed:

Nov 18, 2010

Appl. No.:

12/949149

Inventors:

Ganesan Sathya - Cary NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Hanne Gron - Durham NC, US

Assignee:

AFFINERGY, INC. - Research Triangle Park NC

International Classification:

A61K 9/00
C07K 7/08
C07K 7/06
C07K 19/00
C07K 9/00
C08G 63/91
A61K 38/39
A61K 38/17
A61K 38/02
A61K 31/785
A61F 2/10
A61F 2/08
A61F 2/12
A61P 43/00
A61P 9/00
A61P 17/00
A61P 19/04

US Classification:

424423, 530327, 530326, 530328, 530356, 530357, 530353, 530322, 525 541, 514 82, 514 89, 424 7819, 424 783

Abstract:

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.

US Patent:

20110117169, May 19, 2011

Filed:

Nov 18, 2010

Appl. No.:

12/949767

Inventors:

Isaac Gilliam Sanford - Durham NC, US
Dalia Isolda Juzumiene - Cary NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Jonathan Allen Hodges - Durham NC, US

Assignee:

AFFINERGY, INC. - Research Triangle Park NC

International Classification:

A61K 9/00
C12N 5/071
C12M 1/00
A61K 35/12
C12N 5/073
C12N 5/078
A61P 17/02

US Classification:

424423, 435325, 435378, 435379, 4352831, 424 937

Abstract:

Compositions and methods are provided for capturing cells. Cell binding peptides are provided that bind to one or more of stem cells, fibroblasts, or endothelial cells. In the methods, a sample containing cells is contacted with a cell binding peptide attached to a substrate, and the cells present in the sample are captured onto the substrate through binding to the cell binding peptide.

US Patent:

20110117171, May 19, 2011

Filed:

Nov 18, 2010

Appl. No.:

12/949069

Inventors:

Mora Carolynne Melican - Cary NC, US
Isaac Gilliam Sanford - Durham NC, US
Jonathan Allen Hodges - Durham NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Martyn Kerry Darby - Chapel Hill NC, US

Assignee:

AFFINERGY, INC. - Research Triangle Park NC

International Classification:

A61K 9/00
C12N 5/071
C12N 5/078
A61K 35/12
A61K 35/32
A61K 35/28
A61K 35/14
A61K 35/16
A61K 35/48
A61K 35/50
A61K 33/42
A61K 33/10
A61K 33/06
A61K 33/00
A61P 19/08

US Classification:

424426, 435325, 424 937, 424 9372, 424602, 424687, 424682, 424549, 424677

Abstract:

Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.

US Patent:

20110223142, Sep 15, 2011

Filed:

May 17, 2011

Appl. No.:

13/109802

Inventors:

Isaac Gilliam Sanford - Durham NC, US
Martyn Kerry Darby - Chapel Hill NC, US
Shrikumar Ambujakshan Nair - Cary NC, US
Jonathan Allen Hodges - Durham NC, US
Yuchen Chen - Chapel Hill NC, US
Ganesan Sathya - Cary NC, US
Hanne Gron - Durham NC, US
Michelle Steffen Jansen - Durham NC, US
Paul Theodore Hamilton - Cary NC, US

Assignee:

AFFINERGY, INC. - Research Triangle Park NC

International Classification:

A61K 35/12
C07K 7/08
C07K 14/00
A61K 38/10
A61K 38/16
A61K 38/39
C12N 5/071
A61P 43/00

US Classification:

424 937, 530326, 530325, 530324, 514 214, 514 209, 514 172, 435325

Abstract:

Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells, fibroblasts, or endothelial cells. The growth factor binding peptides include platelet derived growth factor (PDGF) binding peptides and growth differentiation factor (GDF) binding peptides. The tissue for repair includes tendon, muscle, connective tissue, ligament, cardiac tissue, vascular tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and growth factor binding peptides are attached, such as acellular extracellular matrix having attached binding peptide.