Jorge L Acevedo

US Patent:

7074905, Jul 11, 2006

Filed:

Jan 19, 2001

Appl. No.:

09/766378

Inventors:

Peter R. Rhode - Miami FL, US
Jorge Acevedo - Miami FL, US
Martin Burkhardt - Miami FL, US
Jin-an Jiao - Fort Lauderdale FL, US
Hing C. Wong - Fort Lauderdale FL, US

Assignee:

Altor BioScience Corporation - Miramar FL

International Classification:

C07K 16/00
C07K 14/74

US Classification:

530402, 530403, 5303917

Abstract:

The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II β2 chain modification, e. g. , deletion of essentially the entire class II β2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

US Patent:

20040253632, Dec 16, 2004

Filed:

May 16, 2001

Appl. No.:

09/859012

Inventors:

Peter Rhode - Miami FL, US
Vaughan Wittman - Weston FL, US
Jon Weidanz - Amarillo TX, US
Martin Burkhardt - Miami FL, US
Kimberlyn Card - Pembroke Pines FL, US
Rony Tal - Coral Springs FL, US
Jorge Acevedo - Thousand Oaks CA, US
Hing Wong - Weston FL, US

Assignee:

Sunol Molecular Corporation

International Classification:

G01N033/53
G01N033/567

US Classification:

435/007100, 435/007200

Abstract:

Disclosed are methods for identifying compounds that modulate an immune complex that includes a T cell receptor (TCR) and a major histocompatibility complex (MHC) antigen. The invention has many useful applications including providing high throughput screening assays for detecting compositions that can modulate an immune response.

US Patent:

62324454, May 15, 2001

Filed:

Oct 29, 1997

Appl. No.:

8/960190

Inventors:

Peter R. Rhode - Miami FL
Jorge Acevedo - Miami FL
Martin Burkhardt - Miami FL
Jin-an Jiao - Fort Lauderdale FL
Hing C. Wong - Fort Lauderdale FL

Assignee:

Sunol Molecular Corporation - Miramar FL

International Classification:

C12P 2108
C12N 1509
A61K 3900
A61K 39385

US Classification:

5303873

Abstract:

The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II. beta. 2 chain modification, e. g. , deletion of essentially the entire class II. beta. 2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.

US Patent:

6306605, Oct 23, 2001

Filed:

Feb 1, 2000

Appl. No.:

9/496311

Inventors:

Jorge L. Acevedo - Miami FL
Peter R. Rhode - Miami FL

Assignee:

Sunol Molecular Corporation - Miramar FL

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.

US Patent:

61565148, Dec 5, 2000

Filed:

Dec 3, 1998

Appl. No.:

9/204979

Inventors:

Jorge L. Acevedo - Miami FL
Peter R. Rhode - Miami FL

Assignee:

Sunol Molecular Corporation - Miramar FL

International Classification:

C12Q 168

US Classification:

435 6

Abstract:

Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.