Jorge Mariano Leon

Address:

13105 Ixora Ct APT 211, North Miami, FL 33181

VIN:

1HGFA16837L027715

Make:

HONDA

Model:

CIVIC

Year:

2007

Address:

650 Ocean Dr APT 5B, Key Biscayne, FL 33149

VIN:

WBAVA33567KX73272

Make:

BMW

Model:

3 SERIES

Year:

2007

US Patent:

20020040062, Apr 4, 2002

Filed:

Feb 13, 2001

Appl. No.:

09/783053

Inventors:

Paul Fisher - Scarsdale NY, US
Jorge Leon - Tenafly NJ, US

Assignee:

The Trustees of Columbia University - New York NY

International Classification:

A61K031/16

US Classification:

514/625000

Abstract:

A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided for this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.

US Patent:

56818602, Oct 28, 1997

Filed:

Sep 21, 1993

Appl. No.:

8/124716

Inventors:

Paul B. Fisher - Scarsdale NY
Jorge A. Leon - Tenafly NJ

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 3116
A61K 31335
A61K 3121

US Classification:

514629

Abstract:

A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.

US Patent:

61878197, Feb 13, 2001

Filed:

Jun 10, 1996

Appl. No.:

8/619777

Inventors:

Paul B. Fisher - Scarsdale NY
Jorge A. Leon - Tenafly NJ

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 3116
A61K 31355
A61K 3121

US Classification:

514629

Abstract:

A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.

US Patent:

60691743, May 30, 2000

Filed:

Dec 7, 1998

Appl. No.:

9/206798

Inventors:

Paul B. Fisher - Scarsdale NY
Jorge A. Leon - Tenafly NJ

Assignee:

The Trustees of Columbia University in the City of New York - New York NY

International Classification:

A61K 31167

US Classification:

514629

Abstract:

A composition for the upregulation of expression of cell antigens, without inducing shedding, which comprises a protein kinase C activator is provided by this invention. Further provided by this invention is a method of detecting and treating tumor cells comprising contacting tumor cells with an effective amount of a protein kinase C activator for the upregulation of expression of antigens of tumor cells, without inducing antigen shedding, and detecting the presence of said antigen or then further contacting said tumor cells with an effective amount of an antibody directed to said antigen.

US Patent:

20210305038, Sep 30, 2021

Filed:

Mar 24, 2021

Appl. No.:

17/211343

Inventors:

- Brighton MI, US
JORGE LEON - MIAMI FL, US

Assignee:

TBS Scientific LLC - Brighton MI

International Classification:

H01K 3/32
F21V 19/04

Abstract:

The present invention is a device for installing and removing partially obstructed, upward-facing lightbulbs. It is comprised of a gripping element, a weight, a flexible rotary shaft having two ends, and an extension pole having two ends. The gripping element, itself, is comprised of a hollow, three-dimensional gripping element body having an inner and outer surface and a plurality of flexible, tactile members. The hollow, three-dimensional gripping element body is open at one end and closed at the other. At the open end, the plurality of flexible, tactile members are arranged about a peripheral rim at the opening. When the device is placed over a lightbulb, the flexible, tactile members capture the lightbulb. Rotating the extension pole will cause the lightbulb to rotate.

US Patent:

20180294150, Oct 11, 2018

Filed:

Apr 6, 2017

Appl. No.:

15/480855

Inventors:

- Coral Gables FL, US
Jorge Mariano Leon - Miami FL, US

International Classification:

H01K 3/32
H01J 9/00
B25J 1/04

Abstract:

A device for installing and removing lightbulbs comprises a removable gripping element including fingers configured for gripping a lightbulb, a telescopic cylinder coupled to the gripping element, wherein the telescopic cylinder is adjustable to different lengths, and a base housing, comprising: an electric motor located within the housing, a battery, a coupler for coupling the motor to the telescopic cylinder, the coupler comprising a tubular element, wherein the rotating shaft of the electric motor is inserted into an orifice in the first end, and wherein the second end is inserted into the proximal end of the telescopic cylinder, a cylindrical element that surrounds at least a portion of the tubular element, and at least one flange that connects the cylindrical element to the tubular element. The base housing also includes a switch on an exterior surface, the switch for activating power to the electric motor, wherein upon activation of power to the electric motor, the electric motor rotates the shaft, resulting in rotation of the coupler, the telescopic cylinder and the gripping element, thereby rotating a lightbulb to which the gripping element is attached.