Jose B Aponte

US Patent:

20130146542, Jun 13, 2013

Filed:

Feb 6, 2013

Appl. No.:

13/760497

Inventors:

Brown University - Providence RI, US
Jose C. Aponte - Silver Spring MD, US
Rafael Tarozo - Providence RI, US
James Dillon - Pawtucket RI, US

Assignee:

BROWN UNIVERSITY - Providence RI

International Classification:

G01N 30/02
B01D 15/08

US Classification:

210656

Abstract:

Methods, compositions, devices and kits having a novel chromatographic material are provided herein for separating and identifying organic molecules and compounds, for example molecules and compounds containing electron rich functional groups such as carbon-carbon double bonds. The methods, compositions, and kits include a metal-thiolate chromatographic medium (MTCM) with a sulfur-containing functional group or a metal-selenolate chromatographic medium (MSCM) comprising a selenium-containing functional group covalently attached to a support medium, such that the sulfur-containing functional group or selenium-containing functional group is bound to at least one metal atom. The MTCM and/or MSCM has affinity and specificity to compounds having one or more carbon-carbon double bonds, and performs a highly efficient and rapid separation of samples yielding non-overlapping peaks of purified materials compared to traditional media.