Jose Luis Navia

US Patent:

7004925, Feb 28, 2006

Filed:

Feb 25, 2004

Appl. No.:

10/786788

Inventors:

Jose L. Navia - Shaker Heights OH, US
Jose Antonio Navia - Buenos Aires, AR
Jorge Jordana - Buenos Aires, AR

Assignee:

Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61M 37/00
A61M 29/00
A61M 1/14
A61F 2/06

US Classification:

604 614, 604 616, 604 9601, 604 401, 623 111, 623 112, 422 44

Abstract:

An apparatus for automatically retroperfusing a coronary vein includes an intraluminal cannula having a main body portion extending between a proximal end portion and a distal end portion. The proximal end portion is for connecting to an artery outside of the pericardium to automatically supply oxygenated blood from the artery for retroperfusion. The main body portion and the distal end portion are insertable through a vein that is fluidly connected with the coronary vein and into the coronary vein. An expandable stent is attached to the distal end portion for expanding radially into engagement with the interior wall of the coronary vein to secure the distal end portion at a desired location within the coronary vein. Occluding structure for at least partially occluding the coronary vein is provided at the distal end to decrease the back-flow of blood into the right atrium during retroperfusion.

US Patent:

7004926, Feb 28, 2006

Filed:

Sep 10, 2004

Appl. No.:

10/938048

Inventors:

Jose Luis Navia - Shaker Heights OH, US
Jose Antonio Navia - Buenos Aires, AR
Jorge Luis Jordana - Buenos Aires, AR

Assignee:

Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61M 37/00
A61M 29/00
A61M 1/14
A61F 2/06

US Classification:

604 614, 604 616, 604 9601, 604 401, 623 111, 623 112, 422 44, 422 45

Abstract:

An apparatus for automatically retroperfusing a coronary vein includes an intraluminal cannula having a main body portion extending between a proximal end portion and a distal end portion. The proximal end portion is for connecting to an artery outside of the pericardium to automatically supply oxygenated blood from the artery for retroperfusion. The main body portion and the distal end portion are insertable through a vein that is fluidly connected with the coronary vein and into the coronary vein. An expandable stent is attached to the distal end portion for expanding radially into engagement with the interior wall of the coronary vein to secure the distal end portion at a desired location within the coronary vein. Occluding structure for at least partially occluding the coronary vein is provided at the distal end to decrease the back-flow of blood into the right atrium during retroperfusion. The cannula includes passages that allow a limited amount of blood to bypass the occluding structure.

US Patent:

7473237, Jan 6, 2009

Filed:

Jan 5, 2006

Appl. No.:

11/325816

Inventors:

Jose L. Navia - Shaker Heights OH, US
Jose Antonio Navia - Buenos Aires, AR
Jorge Luis Jordana - Buenos Aires, AR

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61M 37/00
A61M 29/00

US Classification:

604 613, 604 616, 604 401, 604 9601, 60410305

Abstract:

An apparatus and method for automatically retroperfusing a coronary vein. The apparatus includes an intraluminal graft having a tubular body extending between a proximal end and a distal end. The proximal end is for fluidly connecting to an artery to automatically supply retrograde blood for retroperfusion. The tubular body and the distal end are extendable into a vein that is fluidly connected with the coronary vein to be retroperfused. The distal end includes an expandable stent for securing the distal end in the coronary vein.

US Patent:

7488346, Feb 10, 2009

Filed:

Jan 18, 2005

Appl. No.:

11/037499

Inventors:

Jose Luis Navia - Shaker Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61F 2/24

US Classification:

623 126, 623904

Abstract:

A method and apparatus for replacing both the native mitral valve and the native aortic valve in a heart with a stentless bioprosthetic graft is provided. The bioprosthetic graft comprises a harvested homograft that includes a mitral valve portion and an aortic valve portion, and an extension portion made of a biocompatible material. The extension portion is sutured to the homograft and is for suturing to the left atrial wall of the heart to close an incision in the left atrial wall following implantation of the mitral valve portion and the aortic valve portion of the homograft.

US Patent:

7914576, Mar 29, 2011

Filed:

May 4, 2007

Appl. No.:

11/800454

Inventors:

Jose Luis Navia - Shaker Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61F 2/24

US Classification:

623 236

Abstract:

An apparatus for repairing a cardiac valve includes an annuloplasty ring having an expandable support member with oppositely disposed proximal and distal end portions and a main body portion between the end portions. The proximal end portion includes a plurality of wing members extending from the main body portion. Each of the wing members includes at least one hook member for embedding into a cardiac wall and a valve annulus to secure the annuloplasty ring therein. The apparatus also includes an energy delivery mechanism for selectively contracting the annuloplasty ring to restrict the valve annulus and correct valvular insufficiency. The energy delivery mechanism includes a detachable electrical lead having distal and proximal end portions. The distal end portion has a securing member for operably attaching the distal end portion to a portion of the expandable support member. The proximal end portion is operably connected to an energy delivery source.

US Patent:

7927371, Apr 19, 2011

Filed:

Oct 26, 2006

Appl. No.:

11/586828

Inventors:

Jose Luis Navia - Shaker Heights OH, US
Jose Antonio Navia - Buenos Aires, AR
Ghassan Kassab - Zionsville IN, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61F 2/24

US Classification:

623 237, 623 236

Abstract:

An apparatus for modifying the annulus of a cardiac valve to reduce regurgitation of blood flow through the cardiac valve includes a first annuloplasty ring having a first diameter and being disposed about a first aspect of the annulus of the cardiac valve. The apparatus also includes an elongate flexible body having proximal and distal end portions and being insertable into the first annuloplasty ring. The elongate flexible body has an adjustable mechanism for selectively adjusting the elongate flexible body from a first relaxed configuration to a second tensioned configuration. The first annuloplasty ring is adaptable to obtain a second smaller diameter and to cause the annulus of the cardiac valve to be modified and reduce regurgitation of blood flow through the cardiac valve when the elongate flexible body obtains the second tensioned configuration.

US Patent:

8105375, Jan 31, 2012

Filed:

Jan 17, 2008

Appl. No.:

12/016168

Inventors:

Jose Luis Navia - Shaker Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61F 2/24

US Classification:

623 21, 623 211, 623 213, 623 214

Abstract:

A method is provided for implanting a valve having at least one valve leaflet within the cardiovascular system of a subject. One step of the method includes preparing a substantially dehydrated bioprosthetic valve and then providing an expandable support member having oppositely disposed first and second ends and a main body portion extending between the ends. Next, the substantially dehydrated bioprosthetic valve is attached to the expandable support member so that the substantially dehydrated bioprosthetic valve is operably secured within the main body portion of the expandable support member. The expandable support member is then crimped into a compressed configuration and placed at a desired location within the cardiovascular system of the subject. Either before or after placement at the desired location, fluid or blood re-hydrates the substantially dehydrated bioprosthetic valve.

US Patent:

8216303, Jul 10, 2012

Filed:

Nov 19, 2008

Appl. No.:

12/274087

Inventors:

Jose Luis Navia - Shaker Heights OH, US

Assignee:

The Cleveland Clinic Foundation - Cleveland OH

International Classification:

A61F 2/24

US Classification:

623 236, 623 126

Abstract:

An apparatus is provided for treating regurgitation of blood flow through a diseased heart valve. The apparatus includes an annular support member and at least one posterior leaflet support member. The annular support member has an anterior end portion, a posterior end portion, and oppositely disposed first and second intermediate portions extending between the end portions. The at least one posterior leaflet support member is securely connected to the annular support member and is dimensioned to extend across a portion of a free edge of a posterior valve leaflet. The posterior leaflet support member comprises an arcuate center portion integrally formed with and extending between first and second end portions. The arcuate center portion has a concave shape relative to the anterior end portion. At least one of the first and second end portions is securely attached to the posterior end portion.