Josep O Dalmau

US Patent:

7026450, Apr 11, 2006

Filed:

Jan 4, 2002

Appl. No.:

10/037860

Inventors:

Jerome B. Posner - New York NY, US
Josep O. Dalmau - New York NY, US
Myrna R. Rosenfeld - New York NY, US

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

C07K 14/00
C07K 5/00

US Classification:

530350, 530300

Abstract:

Ma family polypeptides Ma1, Ma2, Ma3, Ma4 and Ma5 are disclosed, as are nucleic acids encoding the Ma family polypeptides, antibodies that bind to Ma family polypeptides, and methods of diagnosis of paraneoplastic syndromes, by assessing a test sample from an individual for the presence or absence, or amount, of antibodies to Ma family polypeptides.

US Patent:

7972796, Jul 5, 2011

Filed:

Nov 24, 2008

Appl. No.:

12/277252

Inventors:

Josep Dalmau - Philadelphia PA, US
Myrna Rosenfeld - Philadelphia PA, US
David R. Lynch - Bleubell PA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

G01N 33/53

US Classification:

435 71

Abstract:

This invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of testing a biological sample of the subject for an antibody to an NR1 subunit of the NMDA receptor. This invention further provides methods of treating an autoimmune encephalitis or an epilepsy, comprising the steps of detecting an antibody to an NR1 subunit of the NMDA receptor and treating a tumor associated with the disease.

US Patent:

20120213803, Aug 23, 2012

Filed:

Sep 29, 2010

Appl. No.:

13/498355

Inventors:

Josep Dalmau - Delmar NY, US

International Classification:

A61K 39/395
G01N 33/566
A61K 33/24
A61P 25/14
A61P 35/00
A61P 25/08
A61P 25/00
G01N 33/567
A61P 37/00

US Classification:

4241741, 435 721, 436501, 424649

Abstract:

This invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of testing a biological sample of the subject for an anti-body to a GABAreceptor. This invention further provides methods of treating an autoimmune encephalitis or an epilepsy, comprising the steps of detecting an antibody to a GABAreceptor and treating a tumor associated with the disease.

US Patent:

20130072582, Mar 21, 2013

Filed:

May 11, 2011

Appl. No.:

13/696884

Inventors:

Josep Dalmau - Delmar NY, US

International Classification:

G01N 33/68

US Classification:

514789, 435 721

Abstract:

The invention provides methods of diagnosing or determining a cause of an autoimmune encephalitis or an epilepsy in a subject and of diagnosing a tumor in a subject, comprising the step of testing a biological sample of the subject for an antibody to LGI1. This invention further provides methods of treating an autoimmune encephalitis or an epilepsy, comprising the steps of detecting an antibody to LGI1 and treating a tumor associated with the disease.

US Patent:

6387639, May 14, 2002

Filed:

Nov 10, 1998

Appl. No.:

09/189527

Inventors:

Jerome B. Posner - New York NY
Josep O. Dalmau - New York NY
Myrna R. Rosenfeld - New York NY

Assignee:

Sloan-Kettering Institute for Cancer Research - New York NY

International Classification:

G01N 3353

US Classification:

435 723, 435 71, 435 72, 435 721, 436 64, 436501, 436503, 436811, 436815, 5303871, 4241301

Abstract:

Ma family polypeptides Ma1, Ma2, Ma3, Ma4 and Ma5 are disclosed, as are nucleic acids encoding the Ma family polypeptides, antibodies that bind to Ma family polypeptides, and methods of diagnosis of paraneoplastic syndromes, by assessing a test sample from an individual for the presence or absence, or amount, of antibodies to Ma family polypeptides.