Joseph Augustine Bach

Address:

905 Upper Dr, Newton, NJ 07860

VIN:

1D8GU58X09W536332

Make:

DODGE

Model:

NITRO

Year:

2009

US Patent:

46005340, Jul 15, 1986

Filed:

Oct 18, 1984

Appl. No.:

6/662313

Inventors:

Joseph Bach - Parsippany NJ
Stephen K. Boyer - Far Hills NJ

Assignee:

Ciba-Geigy Corporation - Ardsley NY

International Classification:

C07D22316
C07D40112

US Classification:

2602393B

Abstract:

The invention concerns a novel process for the preparation of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid by opening, preferably under acidic conditions, the caprolactam ring in a compound of formula II ##STR1## wherein COR represents carboxy or esterified carboxy, and hydrolyzing the esterified carboxy group if present. The preparation of the starting materials of formula II is described.

US Patent:

46097333, Sep 2, 1986

Filed:

Dec 27, 1984

Appl. No.:

6/686777

Inventors:

Stephen K. Boyer - Far Hills NJ
Karl O. Gelotte - Watchung NJ
Joseph Bach - Parsippany NJ

Assignee:

Ciba-Geigy Corporation - Ardsley NY

International Classification:

C07D40104

US Classification:

546273

Abstract:

Disclosed is a process for the preparation of a compound of the formula ##STR1## wherein Ar is 3- or 4-pyridyl or 3- or 4-pyridyl substituted by lower alkyl; R. sub. 1 is hydrogen, halogen, trifluoromethyl, lower alkyl, hydroxy, acylated or etherified hydroxy, lower alkylthio; or two of R. sub. 1 on adjacent carbon atoms represent alkylenedioxy; p is 1 or 2; R. sub. 2 represents hydrogen or lower alkyl; E represents C. sub. 1 -C. sub. 11 alkylene, C. sub. 1 -C. sub. 6 alkylenephenylene, C. sub. 1 -C. sub. 6 alkylene-(thio or oxy)-lower alkylene, C. sub. 1 -C. sub. 6 alkylene-(thio or oxy)-phenylene, C. sub. 1 -C. sub. 6 alkylenephenylene-lower alkylene, phenylene-lower alkylene; or E represents a direct bond; and B represents carboxy, esterified carboxy or carbamoyl; which comprises deoxygenating the keto group in a compound of the formula ##STR2## wherein Ar, R. sub. 1, R. sub. 2, p, E and B have meaning as defined above.