Joseph D Carroll

US Patent:

6745466, Jun 8, 2004

Filed:

Mar 14, 2002

Appl. No.:

10/097523

Inventors:

Patrick E. Frye - Seattle WA 98124-2007
Joseph P. Carroll - Seattle WA 98124-2007
James M. Shoji - Seattle WA 98124-2007

International Classification:

B23P 1500

US Classification:

2989001, 29557, 60204

Abstract:

A thruster device and associated methods are provided. The thruster device comprises a frustoconical inner layer and a frustoconical outer layer that surrounds the inner layer such that the inner and outer layers cooperate to define a spiral flow passage therebetween. An outlet, such as a nozzle, is attached to an exit end of the thruster device such that the outlet is in fluid communication with the spiral flow passage. In one embodiment, the thruster device includes an end flow cap that is also attached to the exit end and establishes the fluid communication between the spiral flow passage and the outlet. The end flow cap includes at least one channel for directing the propellant from the spiral flow passage to the outlet. The design of the thruster device allows the frustoconical inner and outer layers to be assembled without galling or damaging the spiral flow passage.

US Patent:

6953777, Oct 11, 2005

Filed:

Mar 9, 2000

Appl. No.:

09/521696

Inventors:

James Keith - Andover MA, US
Joseph M. Carroll - Cambridge MA, US
Jordan S. Pober - Guilford CT, US

Assignee:

Genetics Indtitute LLC - Cambridge MA
Yale University - New Haven CT

International Classification:

A61K038/00
A61K038/21

US Classification:

514 12, 514 2, 514 8, 514885, 424 851, 424 852

Abstract:

The use of interleukin-11 to prevent, to ameliorate, and to treat an immune-mediated disease in a mammal in need of such treatment is disclosed.

US Patent:

6953778, Oct 11, 2005

Filed:

Oct 28, 2002

Appl. No.:

10/281867

Inventors:

Joseph M. Carroll - Cambridge MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K038/00
G01N033/53
C07K014/00

US Classification:

514 12, 530350, 435 792

Abstract:

The present invention relates to methods and compositions for the diagnosis and treatment of hematological disorders, including, but not limited to, apalstic anemia, hemophilia, sickle cell anemia, thalassisemia, blood loss and other blood disorders, e. g. , blood diorders related to bone marrow irradiation or chemotherapy treatment or renal failure. The invention further provides methods for identifying a compound capable of treating a hematological disorder. The invention also provides methods for identifying a compound capable of modulating a hematopoietic cell activity. Yet further, the invention provides a method for modulating a hematopoietic cell activity. In addition, the invention provides a method for treating a subject having a hematological disorder characterized by aberrant 2777 polypeptide activity or aberrant 2777 nucleic acid expression. In another aspect, the invention provides methods for increasing hematopoietic cell proliferation in a subject and methods for modulating hematopoietic cell apoptosis in a subject.

US Patent:

7045505, May 16, 2006

Filed:

Sep 27, 2002

Appl. No.:

10/256537

Inventors:

Joseph M. Carroll - Cambridge MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

A61K 38/00

US Classification:

514 12

Abstract:

Isolated nucleic acids molecules, designated 69039 nucleic acid molecules, which encode novel Na/Ca exchanger members, are disclosed. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 69039 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 69039 gene has been introduced or disrupted. Isolated 69039 proteins, fusion proteins, antigenic peptides and anti-69039 antibodies are also disclosed. The invention further provides methods of treating, preventing and diagnosing hematopoietic and neurological disorders.

US Patent:

7094587, Aug 22, 2006

Filed:

Mar 18, 2003

Appl. No.:

10/391364

Inventors:

Rachel E. Meyers - Newton MA, US
Joseph M. Carroll - Cambridge MA, US
William James Cook - Hanover NH, US
Nadine S. Weich - Brookline MA, US
Rajasekhar Bandaru - Watertown MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 9/12

US Classification:

435194, 536 232

Abstract:

The invention provides isolated nucleic acids molecules, designated 16002 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16002 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16002 gene has been introduced or disrupted. The invention still further provides isolated 16002 proteins, fusion proteins, antigenic peptides and anti-16002 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

7098015, Aug 29, 2006

Filed:

Mar 11, 2003

Appl. No.:

10/386414

Inventors:

Kyle J. MacBeth - Boston MA, US
Joseph M. Carroll - Cambridge MA, US
William James Cook - Hanover NH, US
Rachel E. Meyers - Newton MA, US
Miyoung Chun - Belmont CA, US
Mark J. Williamson - Saugus MA, US

Assignee:

Millennium Pharmaceuticals, Inc. - Cambridge MA

International Classification:

C12N 9/16
C12N 15/54
C12N 15/62
C12N 15/79

US Classification:

435196, 435 691, 435 697

Abstract:

The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

US Patent:

7236637, Jun 26, 2007

Filed:

Nov 21, 2001

Appl. No.:

09/996320

Inventors:

Saad A. Sirohey - Pewaukee WI, US
Robert D. Barnes - Palatine IL, US
Joseph M. Carroll - Arlington Heights IL, US

Assignee:

GE Medical Systems Information Technologies, Inc. - Milwaukee WI

International Classification:

G06K 9/36
G06K 9/32

US Classification:

382240, 382299

Abstract:

The present technique selectively handles image data, which is decomposed into a plurality of resolution levels. The image data may be retrieved in order of progressively higher resolution levels for display in a viewport. Initially, the image data may be displayed in the viewport at a relatively lower one of the plurality of resolution levels. As a user desires higher resolution displays of all or part of the image, one or more of the progressively higher resolution levels may be retrieved and scaled to fit the viewport. Accordingly, the present technique handles the data more efficiently by accessing the image data in blocks corresponding to the plurality of resolution levels, rather than accessing the entirety of the image data. A scaling threshold also can be used to signal the need for a next higher level of the plurality of resolution levels.

US Patent:

7250262, Jul 31, 2007

Filed:

Jan 28, 2003

Appl. No.:

10/352684

Inventors:

Joseph M. Carroll - Cambridge MA, US
Aileen Healy - Medford MA, US
Nadine S. Weich - Brookline MA, US
Louise M. Kelly - Brookline MA, US

Assignee:

Bayerhealth Care AG - Leverkusen

International Classification:

G01N 33/53

US Classification:

435 71, 514 2, 514 12, 530350, 5303871, 530300

Abstract:

The present invention relates to methods for the diagnosis and treatment of hematological disorders. Specifically, the present invention identifies the differential expression of 131, 148, 199, 12303, 13906, 15513, 17822, 302, 5677, 194, 14393, 28059, 7366, 12212, 1981, 261, 12416, 270, 1410, 137, 1871, 13051, 1847, 1849, 15402, 340, 10217, 837, 1761, 8990 and 13249 genes in tissues relating to hematological disorders sensation, relative to their expression in normal, or non-hematological disorders disease states, and/or in response to manipulations relevant to hematological disorders. The present invention describes methods for the diagnostic evaluation and prognosis of various hematological disorders, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating hematological disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of hematological disorders.