Joseph Mike Costello

US Patent:

20220266022, Aug 25, 2022

Filed:

Feb 9, 2022

Appl. No.:

17/650492

Inventors:

- Valencia CA, US
Hemant Bokil - Cambridge MA, US
Joseph Costello - Ann Arbor MI, US

International Classification:

A61N 1/36
A61N 1/05

Abstract:

Methods and systems for using sensed evoked neural responses for informing aspects of neurostimulation therapy are disclosed. Electrical signals may be recorded during the provision of electrical stimulation to a patient's neural tissue. The electrical signals may be processed and analyzed using one or more classification criteria to determine if the electrical signals contain a neural response of interest. Examples of such neural responses include evoked neural responses that are oscillatory and/or resonant in nature. If the electrical signals include such responses of interest, one or more features may be extracted from the signals and used as biomarkers for informing aspects of neurostimulation therapy, such as directing lead placement, optimizing stimulation parameters, closed-loop feedback control of stimulation, and the like. Various methods and systems described herein are particularly relevant in the context of multi-site stimulation paradigms, such as coordinated reset neuromodulation.