Joseph C Dougherty

US Patent:

RE38333, Nov 25, 2003

Filed:

May 29, 2002

Appl. No.:

10/159888

Inventors:

Murty N. Arimilli - Fremont CA
Kenneth C. Cundy - Belmont CA
Joseph P. Dougherty - New York NY
Choung U. Kim - San Carlos CA
Reza Oliyai - Foster City CA
Valentino J. Stella - Lawrence KS

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07F 96512

US Classification:

544243, 544244, 546 23

Abstract:

Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure âOC(R ) OC(O)X(R) , wherein R independently is H, C -C alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro or OR in which R is C -C alkyl; X is N or O; R is independently H, C -C alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro, âOâ, âN , âNR â, âN(R ) â or OR , R independently is âH or C -C alkyl, provided that at least one R is not H; and a is 1 or 2, with the proviso that when a is 2 and X is N, (a) two R groups can be taken together to form a carbocycle or oxygen-containing heterocycle, or (b) one R additionally can be OR. The compounds are useful as intermediates for the preparation of antiviral compounds or oligonucleotides, or are useful for administration directly to patients for antiviral therapy of prophylaxis. Embodiments are particularly useful when administered orally.

US Patent:

59770899, Nov 2, 1999

Filed:

Nov 6, 1998

Appl. No.:

9/187763

Inventors:

Murty N. Arimilli - Fremont CA
Kenneth C. Cundy - Belmont CA
Joseph P. Dougherty - New York NY
Choung U. Kim - San Carlos CA
Reza Oliyai - Foster City CA
Valentino J. Stella - Lawrence KS

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31675
C07F 96561

US Classification:

514 81

Abstract:

Compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R. sup. 2). sub. 2 OC(O)X(R). sub. a, wherein R. sup. 2 independently is H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro or OR. sup. 3 in which R. sup. 3 is C. sub. 1 -C. sub. 12 alkyl; X is N or O; R is independently H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro, --O--, --N. dbd. , --NR. sup. 4 --, --N(R. sup. 4). sub. 2 -- or OR. sup. 3, R. sup.

US Patent:

59226951, Jul 13, 1999

Filed:

Jul 25, 1997

Appl. No.:

8/900746

Inventors:

Murty N. Arimilli - Fremont CA
Kenneth C. Cundy - Belmont CA
Joseph P. Dougherty - New York NY
Choung U. Kim - San Carlos CA
Reza Oliyai - Foster City CA
Valentino J. Stella - Lawrence KS

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31675
C07F 96512
C07F 96561

US Classification:

514 81

Abstract:

Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R. sup. 2). sub. 2 OC(O)X(R). sub. a, wherein R. sup. 2 independently is H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro or OR. sup. 3 in which R. sup. 3 is C. sub. 1 -C12 alkyl; X is N or O; R is independently H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro, --O--, --N. dbd. , --NR. sup. 4 --, --N(R. sup. 4). sub. 2 -- or OR. sup. 3, R. sup.

US Patent:

60692499, May 30, 2000

Filed:

May 19, 1999

Appl. No.:

9/314607

Inventors:

Murty N. Arimilli - Fremont CA
Kenneth C. Cundy - Belmont CA
Joseph P. Dougherty - New York NY
Choung U. Kim - San Carlos CA
Reza Oliyai - Foster City CA
Valentino J. Stella - Lawrence KS

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

C07F 96512
C07F 96561

US Classification:

544243

Abstract:

Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure --OC(R. sup. 2). sub. 2 OC(O)X(R). sub. a, wherein R. sup. 2 independently is H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro or OR. sup. 3 in which R. sup. 3 is C. sub. 1 -C. sub. 12 alkyl; X is N or O; R is independently H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro, --O--, --N. dbd. , --NR. sup. 4 --, --N(R. sup. 4). sub. 2 -- or OR. sup. 3, R. sup.

US Patent:

60432306, Mar 28, 2000

Filed:

May 19, 1999

Appl. No.:

9/314606

Inventors:

Murty N. Arimilli - Fremont CA
Kenneth C. Cundy - Belmont CA
Joseph P. Dougherty - New York NY
Choung U. Kim - San Carlos CA
Reza Oliyai - San Ramon CA
Valentino J. Stella - Lawrence KS

Assignee:

Gilead Sciences, Inc. - Foster City CA

International Classification:

A61K 31675
C07F 96512

US Classification:

514 81

Abstract:

Novel compounds are provided that comprise esters of antiviral phosphonomethoxy nucleotide analogs with carbonates and/or carbamates having the structure -OC(R. sup. 2). sub. 2 OC(O) X(R). sub. a, wherein R. sup. 2 independently is H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, azido, nitro or OR. sup. 3 in which R. sup. 3 is C. sub. 1 -C12 alkyl; X is N or O; R is independently H, C. sub. 1 -C. sub. 12 alkyl, aryl, alkenyl, alkynyl, alkyenylaryl, alkynylaryl, alkaryl, arylalkynyl, arylalkenyl or arylalkyl which is unsubstituted or is substituted with halo, axido, nitro, --O--, --N. dbd. , --NR. sup. 4 --, --N(R. sup. 4). sub. 2 -- or OR. sup. 3, R. sup.