Joseph Alex Frank

US Patent:

51006464, Mar 31, 1992

Filed:

Jul 25, 1990

Appl. No.:

7/557038

Inventors:

Peter L. Choyke - Bethesda MD
Joseph A. Frank - Potomac MD
Howard A. Austin - Bethesda MD

Assignee:

The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC

International Classification:

G01N 3100
G01N 2400
A61K 3128
A61K 3119

US Classification:

424 9

Abstract:

A method of determining the glomerular filtration rate of a subject comprises (1) obtaining a serum sample S. sub. pre and a urine sample U. sub. pre from a subject; (2) administering to the subject an amount of a paramagnetic substance that is filtered by the kidneys and is readily detectable by NMR in serum and urine; (3) allowing for the concentration of the substance to equilibrate between the blood and the extravascular spaces; (4) separating an aliquot of the urine sample v. sub. A and obtaining a serum sample from the subject at the time t. sub. A ; (5) calculating a urine rate (v/a). sub. A from the formula (v/a). sub. A =V. sub. A /a. sub. A ; (6) measuring the magnetic resonance relaxation times of the serum and urine samples, (7) obtaining the concentrations of the paramagnetic substance in the serum samples and the urine samples by comparing their relaxation times to a standard; and (8) calculating GFR from the formula ##EQU1##.

US Patent:

20200399618, Dec 24, 2020

Filed:

Jan 31, 2020

Appl. No.:

16/778653

Inventors:

- CHARLOTTESVILLE VA, US
SEPEHR ZOMORODI - HERNDON VA, US
ZACHERY GEORGE DAVIS - RICE VA, US
AMEER HAMZA SHAKEEL - ASHBURN VA, US
JOSEPH FRANK - CHARLOTTESVILLE VA, US
SHAUN RAFIE MOSHASHA - CHARLOTTESVILLE VA, US
ANDREI KHOKHLACHEV - CHARLOTTESVILLE VA, US
MARK KESTER - AFTON VA, US

Assignee:

UNIVERSITY OF VIRGINIA PATENT FOUNDATION - CHARLOTTESVILLE VA

International Classification:

C12N 9/16
C07K 14/195
A62D 3/02

Abstract:

Compositions and methods related to anucelate cells (e.g., bacterial minicells) for pesticide degradation applications including related cells, polypeptides, and vectors.

US Patent:

20190169582, Jun 6, 2019

Filed:

Apr 11, 2017

Appl. No.:

16/092697

Inventors:

- CHARLOTTESVILLE VA, US
SEPEHR ZOMORODI - HERNDON VA, US
ZACHERY GEORGE DAVIS - RICE VA, US
AMEER HAMZA SHAKEEL - ASHBURN VA, US
JOSEPH FRANK - CHARLOTTESVILLE VA, US
SHAUN RAFIE MOSHASHA - CHARLOTTESVILLE VA, US
ANDREI KHOKHLACHEV - CHARLOTTESVILLE VA, US
MARK KESTER - AFTON VA, US

Assignee:

UNIVERSITY OF VIRGINIA PATENT FOUNDATION - CHARLOTTESVILLE VA

International Classification:

C12N 9/16
A62D 3/02

Abstract:

Compositions and methods related to anucelate cells (e.g., bacterial minicells) for pesticide degradation applications including related cells, polypeptides, and vectors.