Joseph M Gorman

US Patent:

20120148630, Jun 14, 2012

Filed:

Sep 19, 2008

Appl. No.:

12/679147

Inventors:

Robert C. Gorman - Lower Gwynedd PA, US
Joseph H. Gorman - Lower Gwynedd PA, US
Liam P. Ryan - Boston MA, US

Assignee:

The Trustees of the University of Pennsylvania - Philadelphia PA

International Classification:

A61K 33/42
A61P 9/10
A61K 33/00
A61M 25/00
A61K 9/14

US Classification:

424400, 604523, 424602, 424600

Abstract:

Provided are methods and kits for safe and effective therapy that can be administered early after a heart attack in order to prevent progressive heart dilatation and resultant loss of function. The therapy includes the administration of particulate compositions to a region comprising an infarct or a portion thereof.

US Patent:

20170365057, Dec 21, 2017

Filed:

Sep 6, 2017

Appl. No.:

15/697169

Inventors:

- Philadelphia PA, US
Robert C. Gorman - Lower Gwynedd PA, US
Joseph H. Gorman - Lower Gwynedd PA, US
Alison M. Pouch - Philadelphia PA, US
Chandra M. Sehgal - Wayne PA, US
Paul A. Yushkevich - Wynnewood PA, US
Brian B. Avants - Philadelphia PA, US
Hongzhi Wang - Boiling Springs PA, US

International Classification:

G06T 7/00
A61B 8/08
A61B 8/12
G06F 17/50
G06T 3/40
G06K 9/62
G06T 7/13
G06K 9/46
G06K 9/52
G06T 7/60

Abstract:

A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape. The regional leaflet stress distributions may be predicted in normal and diseased (regurgitant) mitral valves using the techniques of the invention.

US Patent:

20170035298, Feb 9, 2017

Filed:

Apr 24, 2015

Appl. No.:

15/304176

Inventors:

- Philadelphia PA, US
Walter R.T, WITSCHEY - Philadelphia PA, US
Robert C. GORMAN - Lower Gwynedd PA, US
Yuchi HAN - Philadelphia PA, US
Joseph H. GORMAN - Lower Gwynedd PA, US

International Classification:

A61B 5/00
G01R 33/561
G01R 33/567
A61B 5/055
G01R 33/48

Abstract:

A retrospective reconstruction method uses cardiac self-gating for patients with severe arrhythmias. Self-gated myocardial systolic and diastolic motion is determined from low-spatial and high-temporal resolution images and then the MRI-data-set is retrospectively reconstructed to obtain high quality images. The method uses undersampled image reconstruction to obtain the low-spatial and high-temporal resolution images, including those of different beat morphologies. Processing of these images is utilized to generate a cardiac phase signal. This signal allows for arrhythmia detection and cardiac phase sorting. The cardiac phase signal allows for detection of end-systolic and diastolic events which allows for improved sampling efficiency. In the case of frequent and severe arrhythmia, the method utilizes data from the normal and interrupted beats to improve sampling and image quality.

US Patent:

20160035087, Feb 4, 2016

Filed:

Mar 12, 2014

Appl. No.:

14/774325

Inventors:

Brian B. AVANTS - , US
- Philadelphia PA, US
Joseph H. Gorman - Lower Gwynedd PA, US
Alison M. Pouch - Philadelphia PA, US
Chandra M. Sehgal - Wayne PA, US
Paul A. Yushkevich - Wynnewood PA, US
Brian B. Avants - Philadelphia PA, US
Hongzhi Wang - Boiling Springs PA, US

International Classification:

G06T 7/00
G06K 9/46
G06T 3/40
G06T 7/60
G06K 9/52
A61B 8/08
G06K 9/62

Abstract:

A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived patient-specific model of the heart valve leaflets, and applying the image-derived patient-specific model of the heart valve leaflets to a finite element analysis (FEA) algorithm to estimate stresses on the heart valve leaflets. The images of the heart valve leaflets may be obtained using real-time 3D transesophageal echocardiography (rt-3DTEE). Volumetric images of the mitral valve at mid-systole may be analyzed by user-initialized segmentation and 3D deformable modeling with continuous medial representation to obtain, a compact representation of shape. The regional leaflet stress distributions may be predicted in normal and diseased (regurgitant) mitral valves using the techniques of the invention.

US Patent:

20150011821, Jan 8, 2015

Filed:

Dec 21, 2012

Appl. No.:

14/366524

Inventors:

- Philadelphia PA, US
Matthew J. Gillespie - Bryn Mawr PA, US
Joseph H. Gorman - Lower Gwynedd PA, US

International Classification:

A61F 2/24

US Classification:

600 37

Abstract:

A transvenously deployed myocardial restraint device provides mechanical restraint of a dilated left ventricle and improves heart function. The device includes a delivery wire with a restraining coil that is straightened for percutaneous delivery to the heart and recoiled once positioned in a pericardial space adjacent a ventricular heart wall. Alternatively, a balloon on the end of the delivery wire is delivered similarly to the coil and is then inflated in the pericardial space to restrain the dilated portion of the left ventricle. A trailing end of the coil forms a tether that is anchored to the left ventricular free wall and to the ventricular septum by an intraventricular septal anchor and connected by the tether through the ventricular septum using the same delivery system.

US Patent:

20140357938, Dec 4, 2014

Filed:

Nov 30, 2012

Appl. No.:

14/361502

Inventors:

- Philadelphia PA, US
Robert C. Gorman - Gwynedd PA, US
Joseph H. Gorman - Lower Gwynedd PA, US

International Classification:

A61M 1/12

US Classification:

600 17, 600 16

Abstract:

A method and device are provided for non-blood contact mechanically assisting an injured (e.g., infarcted) ventricle by coupling an inflatable bladder or other volume adjustable device to the injured ventricle and selectively inflating the bladder or increasing the size of the volume in systole to apply force against the injured ventricle and deflating the bladder or reducing the size of the volume in diastole to remove force against the injured ventricle. When no mechanical assistance is being provided to the injured ventricle, the inflatable bladder or volume adjustable device is preferably maintained at a predetermined pressure so as to selectively stiffen the injured tissue and alter ventricular geometry a desired amount. The method is implemented by a mechanical assist device including the volume adjustable device, a coupling means that couples the volume adjustable device to the injured ventricle, a pulsatile device that selectively increases and decreases the volume of the volume adjustable device, and a controller responsive to the pace of the heart and adapted to selectively change the size of the volume adjusting device in different modes of operation.

US Patent:

20140350669, Nov 27, 2014

Filed:

Nov 30, 2012

Appl. No.:

14/361466

Inventors:

- Philadelphia PA, US
Joseph H. Gorman - Gwynedd PA, US
Robert C. Gorman - Lower Gwynedd PA, US

Assignee:

The Trustees if The University of Pennsylvania - Philadelphia PA

International Classification:

A61F 2/24

US Classification:

623 218

Abstract:

A self-expanding valved stent is constructed from a polytetrafluoroethylene (PTFE) covered nitinol or stainless steel wire frame. Anchoring is facilitated by arms emanating from the ventricular end of the device that are designed to atraumatically insinuate themselves around chordae and leaflets and trap them against the expanded stent body. The valve prosthesis includes a partially self-expanding stent having a wire framework defining outer and interior surfaces and anchoring arms. The stent has an unexpaneled and an expanded state and anchoring arms having an elbow region and a hook that clamps around mitral tissue of the patient when seated. An elastic fabric/cloth made of for example, PTFE material, is wrapped circumferentially around the wire framework. A valve having at least one leaflet is fixedly attached to the interior surface of the stent.