Matthew J. Fisher - Carmel IN Anne Marie Happ - Indianapolis IN Joseph A. Jakubowski - Indianapolis IN Michael Dean Kinnick - Indianapolis IN Allen D. Kline - Bargersville IN Michael John Martinelli - Indianapolis IN Michael Paal - Hamburg, DE Gerd Rühter - Hamburg, DE Kenneth James Ruterbories - Indianapolis IN Daniel J. Sall - Greenwood IN Theo Schotten - Vierhoefen, DE Marshall A. Skelton - Indianapolis IN Wolfgang Stenzel - Reinbek, DE Robert Theodore Vasileff - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D40112
US Classification:
514320, 514456, 546205, 549398
Abstract:
This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Matthew J. Fisher - Carmel IN Anne Marie Happ - Indianapolis IN Joseph A. Jakubowski - Indianapolis IN Michael Dean Kinnick - Indianapolis IN Allen D. Kline - Bargersville IN Daniel J. Sall - Greenwood IN Marshall A. Skelton - Indianapolis IN Robert Theodore Vasileff - Indianapolis IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
C07D21716
US Classification:
514309, 514307, 546141, 546142, 546143, 546147
Abstract:
This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Spiro Compounds As Inhibitors Of Fibrinogen-Dependent Platelet Aggregation
Matthew J. Fisher - Carmel IN Joseph A. Jakubowski - Indianapolis IN John J. Masters - Indianapolis IN Jeffrey T. Mullaney - Indianapolis IN Kenneth J. Ruterbories - Indianapolis IN Michael Paal - Hamburg, DE Gerd Ruhter - Hamburg, DE Theo Schotten - Vierhoefen, DE Wolfgang Stenzel - Reinbek, DE Robert M. Scarborough - Belmont CA
Assignee:
Millennium Pharmaceuticals, Inc. - Cambridge MA Eli Lilly and Company - Indianapolis IN
International Classification:
C07D26352
US Classification:
514376, 548216
Abstract:
This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Robert M. Scarborough - Half Moon Bay CA Mark Smyth - Foster City CA Ting Su - Belmont CA Matthew J. Fisher - Mooresville IN Joseph A. Jakubowski - Indianapolis IN John J. Masters - Indianapolis IN Jeffry Bernard Franciskovich - Indianapolis IN
Novel compounds, their salts and compositions related thereto having activity against mammalian integrins are disclosed. The compounds are useful in vitro or in vivo for preventing or treating thrombotic or restenotic disorders.
Spiro Compounds As Inhibitors Of Fibrinogen-Dependent Platelet Aggregation
Matthew J. Fisher - Carmel IN Joseph A. Jakubowski - Indianapolis IN John J. Masters - Indianapolis IN Jeffrey T. Mullaney - Indianapolis IN Michael Paal - Hamburg, DE Gerd Ruhter - Hamburg, DE Kenneth J. Ruterbories - Indianapolis IN Robert M. Scarborough - Belmont CA Theo Schotten - Vierhoefen, DE Wolfgang Stenzel - Reinbek, DE
Assignee:
Eli Lilly and Company - Indianapolis IN Millennium Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07D22120
US Classification:
514278, 546 19
Abstract:
This invention relates to certain spirocyclic compounds substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Matthew Fisher - Carmel IN, US Anne Happ - Indianapolis IN, US Joseph Jakubowski - Indianapolis IN, US Michael Kinnick - Indianapolis IN, US Allen Kline - Bargersville IN, US Michael Martinelli - Indianapolis IN, US John Morin - Brownsburg IN, US Michael Paal - Hamburg, DE Gerd Ruhter - Hamburg, DE Kenneth Ruterbories - Indianapolis IN, US Daniel Sall - Greenwood IN, US Theo Schotten - Vierhoefen, DE Marshall Skelton - Indianapolis IN, US Wolfgang Stenzel - Reinbek, DE Robert Vasileff - Indianapolis IN, US
International Classification:
C07D319/14 C07D311/74 A61K031/335 A61K031/353
US Classification:
514/452000, 514/456000, 549/398000, 549/362000
Abstract:
This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, benzopyran, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Matthew Fisher - Carmel IN, US Anne Happ - Indianapolis IN, US Joseph Jakubowski - Indianapolis IN, US Michael Kinnick - Indianapolis IN, US Allen Kline - Bargersville IN, US John Morin - Brownsburg IN, US Daniel Sall - Greenwood IN, US Marshall Skelton - Indianapolis IN, US Robert Vasileff - Indianapolis IN, US
This invention relates to certain bicyclic compounds having a nucleus formed of two fused six membered rings, for example, isoquinoline, isoquinolone, tetrahydronaphthalene, dihydronaphthalene, or tetralone, substituted with both basic and acidic functionality, which are useful in inhibition of platelet aggregation.
Glucagon-Like Peptides (Glp-1) And Treatment Of Respiratory Distress
Joseph Jakubowski - Indianapolis IN, US Suad Efendic - Lidingo, SE
International Classification:
A61K038/26
US Classification:
514/012000
Abstract:
This invention relates to the use of glucagon-like peptide (GLP-1) compounds to reduce the mortality and morbidity associated with critical illnesses wherein a patient is predisposed to or suffers from some type of respiratory distress.
Carolinas Healthcare System
Registered Respiratory Therapist
Jcj Cleaning Service Jan 1990 - Jan 1999
Owner
Education:
Central Piedmont Community College 2012
Associates, Associate of Arts
Central Piedmont Community College 2010 - 2012
Associates, Associate of Arts
Edinboro University of Pennsylvania 1982 - 1986
Skills:
Mechanical Ventilation Healthcare Cpr Certified Icu Medication Administration Patient Safety Licensed Respiratory Therapist Basic Life Saving Certified Airway Management Bls Critical Care Acls Acute Care Clinical Research Emr Patient Education Pediatrics
vestigators to a man hed found camping on his property about 125 miles (200 kilometers) northwest of Janesville, Wisconsin. Thats where a manhunt for Joseph Jakubowski, 32, began after authorities said he broke into a gun store April 4 and sent a threatening 161-page manifesto to the White House.
Date: Apr 15, 2017
Category: U.S.
Source: Google
The Latest: Businesses relieved Wisconsin fugitive caught
Dozens of federal, state and local officers have been searching for Joseph Jakubowski since April 4 when authorities say he broke into a gun store near Janesville and stole 18 firearms and mailed a threatening manifesto to the White House.
Date: Apr 14, 2017
Category: U.S.
Source: Google
Letter threatening churches investigated, manhunt continues
The letter mailed by someone claiming to be Joseph Jakubowski threatens unspecified violence on Sunday at churches in the Sussex area, about 25 miles northwest of Milwaukee. Rock County sheriff's officials are trying to determine if the letter is authentic.
Date: Apr 14, 2017
Category: U.S.
Source: Google
The Latest: Reward increased in manhunt for Wisconsin man
The FBI said Tuesday it was increasing its reward from $10,000 to $20,000 to help authorities capture 32-year-old Joseph Jakubowski. Authorities have been searching for Jakubowski since April 4, when authorities believe he stole 18 firearms from a gun store in Janesville, Wisconsin, about 70 miles (
Date: Apr 11, 2017
Category: U.S.
Source: Google
Wisconsin manhunt: Police work to ensure safety of Paul Ryan, family
Joseph Jakubowski, 32, disappeared after allegedly stealing 18 firearms from a gun shop in Janesville.His stepfather, Don McLean, and the suspects mother told The Associated Press they wanted Jakubowski to give himself up because they would rather have him alive.
Date: Apr 11, 2017
Category: U.S.
Source: Google
Joseph Jakubowski manhunt: Schools on alert as police step up search
In the manifesto fromJoseph Jakubowski, 32, he threatened to unleash his stolen weapons on schools and public officials, as well asexpressing anti-religious views, according to the Rock County Sheriffs Office.
MILWAUKEE Before setting off a massive manhunt triggered by a gun shop break-in, authorities said Joseph Jakubowski first wanted to document the start of his self-proclaimed revolution against the government and law enforcement.
Date: Apr 10, 2017
Category: World
Source: Google
Wisconsin churches on alert amid hunt for gun theft suspect
The Rock County Sheriffs Office says 32-year-old Joseph Jakubowski expressed anti-religious views in a 161-page manifesto he sent to the White House. The sheriffs office and Janesville police are increasing patrols near churches Sunday, although investigators say there is no specific threat.
Date: Apr 09, 2017
Category: U.S.
Source: Google
Youtube
Joseph Jakubowski Trial Verdict
Joseph Jakubowski Trial Verdict.
Duration:
8m 4s
Manhunt suspect Joseph Jakubowski speaks at h...
Manhunt suspect Joseph Jakubowski speaks at his sentencing.
Duration:
26m 6s
Joseph Jakubowski sentenced to 19 and a half ...
Joseph Jakubowski, the man who stole 18 guns from a Janesville gun sto...
Duration:
1m 50s
Exclusive: Joseph Jakubowski Explains Why He ...
Captured fugitive calls TODAY'S TMJ4 from jail.
Duration:
2m 45s
Joseph Jakubowski captured
Joseph Jakubowski captured.
Duration:
3m 29s
Homeowner who found Joseph Jakubowski: "He se...
Law enforcement officials were fearing a violent confrontation when th...