Joseph L Kelly

US Patent:

6894063, May 17, 2005

Filed:

Mar 12, 2002

Appl. No.:

10/096390

Inventors:

William J. Greenlee - Teaneck NJ, US
Ying Huang - East Brunswick NJ, US
Joseph M. Kelly - Parlin NJ, US
Stuart W. McCombie - Caldwell NJ, US
Andrew W. Stamford - Chatham Township NJ, US
Yusheng Wu - New York NY, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

A61K031/445
A61K031/435
A61K031/41
C07D421/00
C07C281/00

US Classification:

514315, 514277, 514359, 51421001, 51421201, 546195, 564 37, 540 1, 540484, 548400

Abstract:

A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.

US Patent:

20020165223, Nov 7, 2002

Filed:

Sep 12, 2001

Appl. No.:

09/950908

Inventors:

William Greenlee - Teaneck NJ, US
Ying Huang - East Brunswick NJ, US
Joseph Kelly - Parlin NJ, US
Stuart McCombie - Caldwell NJ, US
Andrew Stamford - Chatham Township NJ, US
Yusheng Wu - New York NY, US

International Classification:

A61K031/55
A61K031/4535
A61K031/4025
A61K031/17
C 07D 4 9/02

US Classification:

514/217030, 514/317000, 514/326000, 514/422000, 514/426000, 514/447000, 514/596000, 540/596000, 546/212000, 546/231000, 548/527000, 548/567000, 564/048000, 549/069000

Abstract:

Compounds represented by structural formula I including its N-oxides wherein Ris H or (C-C)alkyl; Ris H, (C-C)alkyl, (C-C)cycloalkyl or (C-C)cycloalkyl(C-C)alkyl; Z is OR, —N(R)(R) or —NH; j is or k is or l is or m is or Ris -substituents independently selected from the group consisting of H, —OH, halogen, haloalkyl, (C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkyl(C-C)alkyl, —CN, —O(C-C)alkyl, —O(C-C)cycloalkyl, —O(C-C)alkyl(C-C)cycloalkyl, —S(C-C)alkyl, —S(C-C)cycloalkyl, —S(C-C)alkyl(C-C)cycloalkyl, —NH, —NRR, —NO, —CONH, —CONRRand NRCOR; Ris -substituents independently selected from the group consisting of H, halogen, —OH, haloalkyl, haloalkoxy, —CN, —NO, (C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkyl(C-C)alkyl, —O(C-C)alkyl, —O(C-C)cycloalkyl, —O(C-C)alkyl(C-C)cycloalkyl, —CONHand —CONRR; Ris —SO(C-C)alkyl, —SO(C-C)cycloalkyl, —SO(C-C)alkyl(C)cycloalkyl, —SO(C-C)haloalkyl, —SO(hydroxy(C-C)alkyl), —SO(amino(C-C)alkyl), —SO(alkoxy(C-C)alkyl), —SO(alkylamino(C-C)alkyl), —SO(dialkylamino(C-C)alkyl), —SO(aryl), —SO(heteroaryl), —SO(aryl(C-C-alkyl), SON H, —SON RR, —C(O)C-Calkyl, —C(O)C-Ccycloalkyl, —C(O)aryl, —C(O)heteroaryl, —C(O)NRR, —C(O)NH, —C(S)NRR, —C(S)NH, aryl, heteroaryl, —(CH)C(O)NH, —(CH)C(O)NRR, —C( NCN)alkylthio, —C( NCN)NRR, (C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkyl(C-C)alkyl, aryl(C-C)alkyl, heteroaryl(C-C)alkyl or —C(O)OR, N=to R=H or alkyl; Ris H, (C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkyl(C-C)alkyl, aryl, heteroaryl, —SO(C-C)alkyl, —SO(C-C)cycloalkyl, —SO(C-C) alkyl(C-C)cycloalkyl, —SO(C-C)haloalkyl or —SO(aryl); Ris (C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkyl(C-C)alkyl, aryl(C-C)alkyl, aryl or heteroaryl; and, Ris hydrogen, (C-C)alkyl, (C-C)cycloalkyl, (C-C)cycloalkyl(C-C)alkyl, aryl(C-C)alkyl, aryl or heteroaryl; or a pharmaceutically acceptable addition salt and/or hydrate thereof, or prodrug thereof, or Rand Rtaken together can form a -membered ring containing or heteroatoms; or where applicable, a geometric or optical isomer or a racemic mixture thereof, are claimed, as well as additional novel compounds; also claimed are pharmaceutical compositions and methods of using the aforesaid compounds in the treatment of obesity, eating disorders such as hyperphagia and diabetes.

US Patent:

20050038100, Feb 17, 2005

Filed:

Sep 1, 2004

Appl. No.:

10/933016

Inventors:

William Greenlee - Teaneck NJ, US
Ying Huang - East Brunswick NJ, US
Joseph Kelly - Parlin NJ, US
Stuart McCombie - Caldwell NJ, US
Andrew Stamford - Chatham Township NJ, US
Yusheng Wu - New York NY, US

International Classification:

A61K031/40
A61K031/17
C07D207/46

US Classification:

514408000, 514597000, 548577000, 564050000

Abstract:

A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention or amelioration of one or more diseases associated with the neuropeptide Y Y5 receptor are disclosed.

US Patent:

20110204010, Aug 25, 2011

Filed:

Jan 11, 2011

Appl. No.:

13/004026

Inventors:

Ruble Hastu - New York NY, US
Joseph Kelly - New York NY, US

International Classification:

A47B 73/00
B23P 11/00

US Classification:

211 74, 29428

Abstract:

A modular, vertically self-standing wine rack comprising a first vertical planar member and a second vertical planar member having equal measurements and each comprising a plurality of bottle-sized cylindrical through-hole apertures for receiving and retaining bottles of wine. The first vertical planar member and second vertical planar member may be securely held in place at by at least two hinges in a 90 degree adjacent relation to each other thereby the wine rack of the present invention to be self-standing. The through-holes of the present invention may comprise a diameter of 3 inches providing a suitably-sized contact-retention inner circumference surface area for a wine bottle containing a fluid volume of about 750 ml.