Joseph A Lambert

US Patent:

6989519, Jan 24, 2006

Filed:

Sep 2, 2003

Appl. No.:

10/605021

Inventors:

Edward Earl King - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
James Edward Thomas - Harrisburg NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

H05B 6/74

US Classification:

219679, 219687, 219704

Abstract:

A controlled-flow microwave instrument for chemical synthesis using heterogeneous or highly viscous starting materials includes a microwave source for generating electromagnetic radiation in the microwave frequencies, a microwave cavity in wave communication with the source for exposing compositions placed therein to microwave radiation, a microwave-transparent pressure resistant reaction vessel in the cavity, a source reservoir for starting materials and related compositions, a pump in communication with the source reservoir for pumping heterogeneous or highly viscous materials from the source reservoir to the reaction vessel, and a pressure-resistant valve between the pump and the reaction vessel for isolating the reaction vessel from the pump and the source reservoir during application of microwave energy to compositions in the vessel and from any resulting high pressures generated therein.

US Patent:

7041947, May 9, 2006

Filed:

Apr 9, 2004

Appl. No.:

10/709060

Inventors:

Edward Earl King - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
James Edward Thomas - Harrisburg NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

H05B 6/74

US Classification:

219679, 219687

Abstract:

A controlled-flow microwave instrument for chemical synthesis that includes heterogeneous or highly viscous materials. Includes a fluid reservoir for supplying or receiving fluids, a fluid pump in fluid communication with the reservoir for pumping fluids to or from the reservoir, a microwave transparent reaction vessel in fluid communication with the pump for supplying or receiving fluids to or from the pump and the reservoir, a pressure sensor in fluid communication with the reservoir and the vessel for measuring the pressure of fluids in the instrument at the sensor, and a processor in signal communication with the pressure sensor and the pump for controlling the pump and the flow of fluids in the instrument based at least in part on the pressure measured at the sensor.

US Patent:

7109452, Sep 19, 2006

Filed:

Sep 16, 2005

Appl. No.:

11/228767

Inventors:

Edward Earl King - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
James Edward Thomas - Harrisburg NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

H05B 6/74

US Classification:

219679, 219687

Abstract:

A controlled-flow microwave instrument for chemical synthesis that includes heterogeneous or highly viscous materials includes a fluid reservoir for supplying or receiving fluids, a fluid pump in fluid communication with the reservoir for pumping fluids to or from the reservoir, a microwave transparent reaction vessel in fluid communication with the pump for supplying or receiving fluids to or from the pump and the reservoir, a pressure sensor in fluid communication with the reservoir and the vessel for measuring the pressure of fluids in the instrument at the sensor, and a processor in signal communication with the pressure sensor and the pump for controlling the pump and the flow of fluids in the instrument based at least in part on the pressure measured at the sensor.

US Patent:

7214913, May 8, 2007

Filed:

Jun 13, 2005

Appl. No.:

11/151500

Inventors:

Edward Earl King - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
James Edward Thomas - Harrisburg NC, US

Assignee:

CEM, Corporation - Matthews NC

International Classification:

H05B 6/74

US Classification:

219686, 219687, 219679

Abstract:

A controlled-flow microwave instrument for chemical synthesis using heterogeneous or highly viscous starting materials includes a microwave source for generating electromagnetic radiation in the microwave frequencies, a microwave cavity in wave communication with the source for exposing compositions placed therein to microwave radiation, a microwave-transparent pressure resistant reaction vessel in the cavity, a source reservoir for starting materials and related compositions, a pump in communication with the source reservoir for pumping heterogeneous or highly viscous materials from the source reservoir to the reaction vessel, and a pressure-resistant valve between the pump and the reaction vessel for isolating the reaction vessel from the pump and the source reservoir during application of microwave energy to compositions in the vessel and from any resulting high pressures generated therein.

US Patent:

7393920, Jul 1, 2008

Filed:

Jun 23, 2003

Appl. No.:

10/604022

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/04
A61K 38/00
C07K 5/00
C07K 7/00
C07K 16/00
C07K 17/00
C07K 1/00

US Classification:

530333, 530334, 530335, 530336, 530337

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7550560, Jun 23, 2009

Filed:

Sep 26, 2005

Appl. No.:

11/235328

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/00
B01L 3/00

US Classification:

530333, 422 99

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7563865, Jul 21, 2009

Filed:

Sep 26, 2005

Appl. No.:

11/235329

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

A61K 38/00
A01N 37/18

US Classification:

530333, 514 2, 530334, 530335, 530336, 530337

Abstract:

An instrument and process for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.

US Patent:

7582728, Sep 1, 2009

Filed:

Jun 23, 2008

Appl. No.:

12/143979

Inventors:

Jonathan McKinnon Collins - Charlotte NC, US
Joseph Joshua Lambert - Charlotte NC, US
Michael John Collins - Charlotte NC, US

Assignee:

CEM Corporation - Matthews NC

International Classification:

C07K 1/00
C07K 17/00
C07K 5/00
C07K 7/00
C07K 16/00
A61K 38/00

US Classification:

530333, 530334, 530335, 530336, 530337

Abstract:

An instrument and method for accelerating the solid phase synthesis of peptides is disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, then activating a second amino acid by adding the second acid and an activating solution to the same vessel while irradiating the vessel with microwaves, then coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.