Joseph H Lin

US Patent:

6703220, Mar 9, 2004

Filed:

Mar 24, 2000

Appl. No.:

09/535145

Inventors:

Michael S. German - San Francisco CA
Joseph Lin - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 1512

US Classification:

435 691, 435325, 4353201, 4352523, 536 235, 536 231

Abstract:

The present invention features a human neurogenin3 (Ngn3) polypeptide and nucleotide sequences encoding Ngn3 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In addition, the invention features isolated nucleic acid sequence comprising an Ngn3 promoter, as well as a polynucleotide sequences that hybridize under stringent conditions to SEQ ID NO:1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human Ngn3 polypeptide. The present invention also relates to antibodies that bind specifically to a human Ngn3 polypeptide, methods for producing human Ngn3 polypeptides, methods for identifying -cell precursor cells expressing Ngn3, methods for using the Ngn3 gene and the Ngn3 polypeptide to alter cellular differentiation in culture or in vivo to produce new -cells to treat patients with diabetes mellitus, and identification of individuals at risk for diabetes by detecting alteration in Ngn3 coding and regulatory sequences and Ngn3 expression levels.

US Patent:

20110061115, Mar 10, 2011

Filed:

Jun 18, 2007

Appl. No.:

12/308351

Inventors:

Joseph H. Lin - Menlo Park CA, US
Judith A. Shizuru - Palo Alto CA, US

International Classification:

A01K 67/00
C12N 5/00
C12N 5/02
A61K 35/12
C12N 5/07

US Classification:

800 9, 435325, 435383, 424 937, 435354

Abstract:

Substantially enriched mammalian lung endothelial and epithelial progenitor cell populations are provided. Methods are provided for the isolation and in vivo differentiation of such lung progenitor cells. The progenitor cells are obtained from lung tissue, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.

US Patent:

55859780, Dec 17, 1996

Filed:

Aug 30, 1993

Appl. No.:

8/113996

Inventors:

John M. Rottenburg - Dublin CA
Joseph Lin - Cupertino CA
Robert H. Peirce - Del Mar CA
Richard Milo - Lake Forest CA
Michael Andrews - Soquel CA

Assignee:

Conner Peripherals, Inc. - San Jose CA

International Classification:

G11B 5588
G11B 553

US Classification:

360 85

Abstract:

An arcuate scan tape drive for transferring data to and from a data tape, including a base with four side walls and a cover, which base and cover together have a 31/2 inch form factor. Situated within the base and cover is a head carrier assembly for recording data onto and playing back data from the data tape which advances in a longitudinal direction past the head carrier assembly. In one embodiment, the head carrier assembly is provided at an oblique angle with respect to the data tape and the front surface is conically shaped. Thus, during rotation of the head carrier assembly, the recording heads are proximate to the data tape during read or write operations, but are spaced away from the data tape at other times. Also provided within the base is a capstan motor assembly for advancing the data tape, and a cassette positioning mechanism for receiving and securing a data tape cartridge to properly position the tape as it is advanced past the head carrier assembly. The head carrier assembly includes an inside-out spin motor for rotating the head carrier assembly and a pivot motor structure at the rear of the head carrier assembly for pivoting the head carrier assembly in a plane perpendicular to the longitudinal direction of advancement of the tape.

US Patent:

20220200232, Jun 23, 2022

Filed:

Mar 4, 2021

Appl. No.:

17/192470

Inventors:

- San Jose CA, US
Mitchell SRIMONGKOL - Elk Grove CA, US
Joseph LIN - San Jose CA, US

International Classification:

H01S 5/0234

Abstract:

In some implementations, an optical device for mounting in a flip-chip configuration includes a plurality of flip-chip bumps that are arranged in a pattern on the optical device, wherein the pattern is not aligned with a crystal cleavage plane associated with a substrate of the optical device. In some implementations, the optical device further includes a gap that separates a primary region of the optical device and a secondary region of the optical device, wherein at least one portion of a side of the gap is oriented at a non-zero angle to the crystal cleavage plane.

US Patent:

20150239988, Aug 27, 2015

Filed:

Feb 25, 2015

Appl. No.:

14/631574

Inventors:

- Foster City CA, US
Joseph H. Lin - San Mateo CA, US
Victoria Smith - Burlingame CA, US
Maria Vaysberg - Los Altos CA, US

International Classification:

C07K 16/40
A61K 39/395
A61K 45/06

Abstract:

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).