Joseph A Lin

US Patent:

6703220, Mar 9, 2004

Filed:

Mar 24, 2000

Appl. No.:

09/535145

Inventors:

Michael S. German - San Francisco CA
Joseph Lin - San Francisco CA

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C12N 1512

US Classification:

435 691, 435325, 4353201, 4352523, 536 235, 536 231

Abstract:

The present invention features a human neurogenin3 (Ngn3) polypeptide and nucleotide sequences encoding Ngn3 polypeptides. In a particular aspect, the polynucleotide is the nucleotide sequence of SEQ ID NO:1. In addition, the invention features isolated nucleic acid sequence comprising an Ngn3 promoter, as well as a polynucleotide sequences that hybridize under stringent conditions to SEQ ID NO:1. In related aspects the invention features expression vectors and host cells comprising polynucleotides that encode a human Ngn3 polypeptide. The present invention also relates to antibodies that bind specifically to a human Ngn3 polypeptide, methods for producing human Ngn3 polypeptides, methods for identifying -cell precursor cells expressing Ngn3, methods for using the Ngn3 gene and the Ngn3 polypeptide to alter cellular differentiation in culture or in vivo to produce new -cells to treat patients with diabetes mellitus, and identification of individuals at risk for diabetes by detecting alteration in Ngn3 coding and regulatory sequences and Ngn3 expression levels.

US Patent:

20110061115, Mar 10, 2011

Filed:

Jun 18, 2007

Appl. No.:

12/308351

Inventors:

Joseph H. Lin - Menlo Park CA, US
Judith A. Shizuru - Palo Alto CA, US

International Classification:

A01K 67/00
C12N 5/00
C12N 5/02
A61K 35/12
C12N 5/07

US Classification:

800 9, 435325, 435383, 424 937, 435354

Abstract:

Substantially enriched mammalian lung endothelial and epithelial progenitor cell populations are provided. Methods are provided for the isolation and in vivo differentiation of such lung progenitor cells. The progenitor cells are obtained from lung tissue, including fetal and adult tissues. The cells are useful in transplantation, for experimental evaluation, and as a source of lineage and cell specific products, including mRNA species useful in identifying genes specifically expressed in these cells, and as targets for the discovery of factors or molecules that can affect them.

US Patent:

20170295337, Oct 12, 2017

Filed:

Jun 28, 2017

Appl. No.:

15/635262

Inventors:

- Baltimore MD, US
Philippe O. Pouliquen - Baltimore MD, US
Andreas G. Andreou - Baltimore MD, US
Joseph H. Lin - Lowell MA, US

International Classification:

H04N 5/378
H04N 5/374
H04N 5/365
G01J 1/44

Abstract:

A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. A second signal is produced by a collection unit in response to receiving the first signal. The second signal may be modified, in a conditioning unit. A sensing element preprocessing unit generates a word representing the value of the modified second signal, and may produce an indication of change of the first signal. A current value of the word may be stored in a state holding element local to the sensing element, and a previous value of the word may be retained in a further state holding element local to the sensing element.

US Patent:

20170131143, May 11, 2017

Filed:

Jul 2, 2014

Appl. No.:

15/318373

Inventors:

Andreas G. ANDREOU - Baltimore MD, US
Joseph H. LIN - Arlington MA, US
Philippe O. POULIQUEN - Baltimore MD, US
Charbel G. RIZK - Sykesville MD, US
- Baltimore MD, US

International Classification:

G01J 1/44
H01L 31/02
H01L 31/0352
H01L 31/107

Abstract:

A photodetection circuit includes an avalanche photodiode and a mode switching circuit that may be configured to selectively switch an operating mode of the photodetection circuit between linear mode and Geiger mode. The photodetection circuit may further include a quenching circuit configured to quench and reset the avalanche photodiode in response to an avalanche event when the photodetection circuit is operated in Geiger mode. The photodetection circuit may additionally include an integration circuit configured to integrate photocurrent output by the photodiode and generate integrated charge units when the photodetection circuit is operated in linear mode. The photodetection circuit may also include a counter configured to count pulses output by the avalanche photodiode when the photodetection circuit is operated in Geiger mode and to count integrated charge units generated by the integration circuit when the photodetection circuit is operated in linear mode.

US Patent:

20160050382, Feb 18, 2016

Filed:

Oct 27, 2015

Appl. No.:

14/923784

Inventors:

- Baltimore MD, US
Philippe O. Pouliquen - Baltimore MD, US
Andreas G. Andreou - Baltimore MD, US
Joseph H. Lin - Arlington MA, US

International Classification:

H04N 5/378
H04N 5/357

Abstract:

A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. A second signal is produced by a collection unit in response to receiving the first signal. The second signal may be modified, in a conditioning unit. A sensing element preprocessing unit generates a word representing the value of the modified second signal, and may produce an indication of change of the first signal. A current value of the word may be stored in a state holding element local to the sensing element, and a previous value of the word may be retained in a further state holding element local to the sensing element.

US Patent:

20150239988, Aug 27, 2015

Filed:

Feb 25, 2015

Appl. No.:

14/631574

Inventors:

- Foster City CA, US
Joseph H. Lin - San Mateo CA, US
Victoria Smith - Burlingame CA, US
Maria Vaysberg - Los Altos CA, US

International Classification:

C07K 16/40
A61K 39/395
A61K 45/06

Abstract:

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).